Search Results - "Penfold, PL"

Immunological and Aetiological Aspects of Macular Degeneration by Penfold, Philip L, Madigan, Michele C, Gillies, Mark C, Provis, Jan M

“…Aetiological and immunological aspects of AMD, a leading cause of blindness in Western countries, have been reviewed. Developmental studies suggest that…”
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Differential expression of GFAP in early v late AMD: a quantitative analysis by Wu, K H C, Madigan, M C, Billson, F A, Penfold, P L

“…Background/aims: Glial fibrillary acidic protein (GFAP) is an established indicator of retinal stress; its expression in retinal astrocytes and Müller cells…”
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Intravitreal triamcinolone in recurrence of choroidal neovascularisation by Penfold, P L

“…The mode of action of triamcinolone on human choroidal endothelial cells remains to be completely defined The rationale for the use of glucocorticoids for the…”
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Modulation of Permeability and Adhesion Molecule Expression by Human Choroidal Endothelial Cells by Penfold, Philip L, Wen, Li, Madigan, Michele C, King, Nicholas J. C, Provis, Jan M

“…The therapeutic potential of TA, an anti-inflammatory glucocorticoid, for the treatment of exudative retinopathy has been examined in several independent…”
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Triamcinolone acetonide modulates permeability and intercellular adhesion molecule‐1 (ICAM‐1) expression of the ECV304 cell line: implications for macular degeneration by Penfold, P. L., Wen, L., Madigan, M. C., Gillies, M. C., King, N. J. C., Provis, J. M.

“…Whilst animal studies and a pilot clinical trial suggest that intravitreal triamcinolone acetonide (TA) may be useful in the treatment of age‐related macular…”
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Development of the Human Retinal Vasculature: Cellular Relations and VEGF Expression by PROVIS, JAN M, LEECH, JESSICA, DIAZ, CLAUDIA M, PENFOLD, PHILIP L, STONE, JONATHON, KESHET, ELI

“…We have investigated the relationships of the cellular constituents of the retinal vasculature—astrocytes, microglia and pericytes—to the differentiating…”
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Effects of triamcinolone acetonide on microglial morphology and quantitative expression of MHC-II in exudative age-related macular degeneration by Penfold, Philip L, Wong, James G, Gyory, Joseph, Billson, Francis A

“…ABSTRACT Animal models, in vitro assays and pilot clinical studies suggest that intravitreal triamcinolone acetonide may be useful in the treatment of…”
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The Human Hyaloid System: Cell Death and Vascular Regression by Zhu, Meidong, Madigan, Michele C, van Driel, Diana, Maslim, Juliani, Billson, Francis A, Provis, Jan M, Penfold, Philip L

“…The present study had investigated the roles of apoptosis and necrosis in the regression of the human fetal hyaloid vasculature. Normal human fetal hyaloid…”
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Human retinal microglia express candidate receptors for HIV-1 infection by Pham, V T, Wen, L, McCluskey, P, Madigan, M C, Penfold, P L

“…Background/aims: Microglia are the primary antigen presenting cells in the central nervous system and the retina, and can harbour viral antigens that may…”
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Modulation of major histocompatibility complex class II expression in retinas with age-related macular degeneration by Penfold, PL, Liew, SC, Madigan, MC, Provis, JM

“…To investigate antigenic and morphologic features of microglial and vascular elements in the neural retina associated with age-related macular degeneration…”
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Development of microglial topography in human retina by Diaz-Araya, C M, Provis, J M, Penfold, P L, Billson, F A

“…The development of microglial topography in wholemounts of human retina has been examined in the age range 10-25 weeks gestation (WG) using histochemistry and…”
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Human retinal microglia: expression of immune markers and relationship to the glia limitans by Provis, J M, Penfold, P L, Edwards, A J, van Driel, D

“…The immunoreactivity, morphology and relationship to the glia limitans of microglia were investigated in flatmounts and sections of normal human retina, using…”
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Astrocyte Proliferation During Development of the Human Retinal Vasculature by SANDERCOE, TRENT M., MADIGAN, MICHELE C., BILLSON, FRANCIS A., PENFOLD, PHILIP L., PROVIS, JAN M.

“…Wholemounts of human fetal retinas were labeled with antibodies to Ki67 or proliferating cell nuclear antigen, to map the distribution of proliferating cells…”
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The Human Hyaloid System: Cellular Phenotypes and Inter-relationships by ZHU, MEIDONG, PROVIS, JAN M, PENFOLD, PHILIP L

“…We have investigated the expression of leucocyte markers, phenotypic characteristics and cellular relationships of the normal human fetal hyaloid vasculature…”
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Vincristine- and cisplatin-induced apoptosis in human retinoblastoma. Potentiation by sodium butyrate by Conway, R.M, Madigan, M.C, Billson, F.A, Penfold, P.L

“…Chemotherapy alone has largely been unsuccessful in controlling retinoblastoma growth, and has traditionally been limited in use as an alternative to…”
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Human retinal microglia express phenotypic characteristics in common with dendritic antigen-presenting cells by Penfold, P L, Provis, J M, Liew, S C

“…Neural tissue has been considered to be immunologically privileged and major histocompatibility complex (MHC) class II antigens not expressed in normal human…”
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Effects of post-mortem delay and storage duration on the expression of GFAP in normal human adult retinae by Wu, Kathy HC, Penfold, Philip L, Billson, Francis A

“…Glial fibrillary acidic protein (GFAP) is an established marker of retinal glia and has been shown to be modulated by several cytokines and retinal pathology…”
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Intermediate filament expression in human retinal macroglia. Histopathologic changes associated with age-related macular degeneration by Madigan, M C, Penfold, P L, Provis, J M, Balind, T K, Billson, F A

“…Intermediate filament expression by retinal macroglia was studied in normal eyes, normal eyes of older subjects, and eyes of subjects with age-related macular…”
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Ontogeny and cellular expression of MHC and leucocyte antigens in human retina by Diaz-Araya, C M, Provis, J M, Penfold, P L

“…We have investigated the ontogeny of MHC class I, class II, CD45, and macrophage antigens in whole mounts of normal human fetal retina at 10-25 weeks gestation…”
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Senile macular degeneration: the involvement of immunocompetent cells by PENFOLD, P. L, KILLINGSWORTH, M. C, SARKS, S. H

“…Senile macular degeneration (SMD) is a leading cause of legal blindness in western countries. The role of immunocompetent cells in the pathogenesis of this…”
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