Search Results - "Penfold, Christopher A"

Spatial profiling of early primate gastrulation in utero by Bergmann, Sophie, Penfold, Christopher A., Slatery, Erin, Siriwardena, Dylan, Drummer, Charis, Clark, Stephen, Strawbridge, Stanley E., Kishimoto, Keiko, Vickers, Alice, Tewary, Mukul, Kohler, Timo N., Hollfelder, Florian, Reik, Wolf, Sasaki, Erika, Behr, Rüdiger, Boroviak, Thorsten E.

“…Gastrulation controls the emergence of cellular diversity and axis patterning in the early embryo. In mammals, this transformation is orchestrated by dynamic…”
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High-Resolution Temporal Profiling of Transcripts during Arabidopsis Leaf Senescence Reveals a Distinct Chronology of Processes and Regulation by Breeze, Emily, Harrison, Elizabeth, McHattie, Stuart, Hughes, Linda, Hickman, Richard, Hill, Claire, Kiddle, Steven, Kim, Youn-sung, Penfold, Christopher A., Jenkins, Dafyd, Zhang, Cunjin, Morris, Karl, Jenner, Carol, Jackson, Stephen, Thomas, Brian, Tabrett, Alexandra, Legaie, Roxane, Moore, Jonathan D., Wild, David L., Ott, Sascha, Rand, David, Beynon, Jim, Denby, Katherine, Mead, Andrew, Buchanan-Wollaston, Vicky

“…Leaf senescence is an essential developmental process that impacts dramatically on crop yields and involves altered regulation of thousands of genes and many…”
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Arabidopsis Defense against Botrytis cinerea: Chronology and Regulation Deciphered by High-Resolution Temporal Transcriptomic Analysis by Windram, Oliver, Madhou, Priyadharshini, McHattie, Stuart, Hill, Claire, Hickman, Richard, Cooke, Emma, Jenkins, Dafyd J., Penfold, Christopher A., Baxter, Laura, Breeze, Emily, Kiddle, Steven J., Rhodes, Johanna, Atwell, Susanna, Kliebenstein, Daniel J., Kim, Youn-sung, Stegle, Oliver, Borgwardt, Karsten, Zhang, Cunjin, Tabrett, Alex, Legaie, Roxane, Moore, Jonathan, Finkenstadt, Bärbel, Wild, David L., Mead, Andrew, Rand, David, Beynon, Jim, Ott, Sascha, Buchanan-Wollaston, Vicky, Denby, Katherine J.

“…Transcriptional reprogramming forms a major part of a plant's response to pathogen infection. Many individual components and pathways operating during plant…”
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How to infer gene networks from expression profiles, revisited by Penfold, Christopher A., Wild, David L.

“…Inferring the topology of a gene-regulatory network (GRN) from genome-scale time-series measurements of transcriptional change has proved useful for…”
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Comparative transcriptome analysis in Arabidopsis ein2/ore3 and ahk3/ore12 mutants during dark-induced leaf senescence by Kim, Jeongsik, Park, Su Jin, Lee, Il Hwan, Chu, Hyosub, Penfold, Christopher A, Kim, Jin Hee, Buchanan-Wollaston, Vicky, Nam, Hong Gil, Woo, Hye Ryun, Lim, Pyung Ok

“…Ethylene and cytokinin play antagonistic roles in the regulation of leaf senescence via EIN2/ORE3-dependent transcriptional regulation of stress responses and…”
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Stella modulates transcriptional and endogenous retrovirus programs during maternal-to-zygotic transition by Huang, Yun, Kim, Jong Kyoung, Do, Dang Vinh, Lee, Caroline, Penfold, Christopher A, Zylicz, Jan J, Marioni, John C, Hackett, Jamie A, Surani, M Azim

“…The maternal-to-zygotic transition (MZT) marks the period when the embryonic genome is activated and acquires control of development. Maternally inherited…”
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Nonparametric Bayesian inference for perturbed and orthologous gene regulatory networks by Penfold, Christopher A, Buchanan-Wollaston, Vicky, Denby, Katherine J, Wild, David L

“…The generation of time series transcriptomic datasets collected under multiple experimental conditions has proven to be a powerful approach for disentangling…”
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Nuclear transfer system for the direct induction of embryonic transcripts from intra- and cross-species nuclei using mouse 4-cell embryos by Tomikawa, Junko, Penfold, Christopher A., Hatakeyama, Rena, Miyamoto, Kei

“…Reprogramming of somatic nuclei toward the embryonic state has been studied using nuclear transfer (NT) to an oocyte at the metaphase II (MII) stage. In this…”
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Building a stem cell-based primate uterus by Bergmann, Sophie, Schindler, Magdalena, Munger, Clara, Penfold, Christopher A., Boroviak, Thorsten E.

“…The uterus is the organ for embryo implantation and fetal development. Most current models of the uterus are centred around capturing its function during later…”
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Origin and segregation of the human germline by Castillo-Venzor, Aracely, Penfold, Christopher A, Morgan, Michael D, Tang, Walfred Wc, Kobayashi, Toshihiro, Wong, Frederick Ck, Bergmann, Sophie, Slatery, Erin, Boroviak, Thorsten E, Marioni, John C, Surani, M Azim

“…Human germline-soma segregation occurs during weeks 2-3 in gastrulating embryos. Although direct studies are hindered, here, we investigate the dynamics of…”
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Cell division- and DNA replication-free reprogramming of somatic nuclei for embryonic transcription by Tomikawa, Junko, Penfold, Christopher A., Kamiya, Takuma, Hibino, Risa, Kosaka, Ayumi, Anzai, Masayuki, Matsumoto, Kazuya, Miyamoto, Kei

“…Nuclear transfer systems represent the efficient means to reprogram a cell and in theory provide a basis for investigating the development of endangered…”
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Modeling meiotic chromosomes indicates a size dependent contribution of telomere clustering and chromosome rigidity to homologue juxtaposition by Penfold, Christopher A, Brown, Paul E, Lawrence, Neil D, Goldman, Alastair S H

“…Meiosis is the cell division that halves the genetic component of diploid cells to form gametes or spores. To achieve this, meiotic cells undergo a radical…”
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CSI: a nonparametric Bayesian approach to network inference from multiple perturbed time series gene expression data by Penfold, Christopher A, Shifaz, Ahmed, Brown, Paul E, Nicholson, Ann, Wild, David L

“…Here we introduce the causal structure identification (CSI) package, a Gaussian process based approach to inferring gene regulatory networks (GRNs) from…”
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Modelling transcriptional networks in leaf senescence by Penfold, Christopher A., Buchanan-Wollaston, Vicky

“…The process of leaf senescence is induced by an extensive range of developmental and environmental signals and controlled by multiple, cross-linking pathways,…”
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Age‐related and species‐specific methylation changes in the protein‐coding marmoset sperm epigenome by Dittrich, Marcus, Bernhardt, Laura, Penfold, Christopher A., Boroviak, Thorsten E., Drummer, Charis, Behr, Rüdiger, Müller, Tobias, Haaf, Thomas

“…The sperm epigenome is thought to affect the developmental programming of the resulting embryo, influencing health and disease in later life. Age‐related…”
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Sequential enhancer state remodelling defines human germline competence and specification by Tang, Walfred W. C., Castillo-Venzor, Aracely, Gruhn, Wolfram H., Kobayashi, Toshihiro, Penfold, Christopher A., Morgan, Michael D., Sun, Dawei, Irie, Naoko, Surani, M. Azim

“…Germline–soma segregation is a fundamental event during mammalian embryonic development. Here we establish the epigenetic principles of human primordial germ…”
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A local regulatory network around three NAC transcription factors in stress responses and senescence in Arabidopsis leaves by Hickman, Richard, Hill, Claire, Penfold, Christopher A., Breeze, Emily, Bowden, Laura, Moore, Jonathan D., Zhang, Peijun, Jackson, Alison, Cooke, Emma, Bewicke‐Copley, Findlay, Mead, Andrew, Beynon, Jim, Wild, David L., Denby, Katherine J., Ott, Sascha, Buchanan‐Wollaston, Vicky

“…Summary A model is presented describing the gene regulatory network surrounding three similar NAC transcription factors that have roles in Arabidopsis leaf…”
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Microgel culture and spatial identity mapping elucidate the signalling requirements for primate epiblast and amnion formation by Munger, Clara, Kohler, Timo N, Slatery, Erin, Ellermann, Anna L, Bergmann, Sophie, Penfold, Christopher A, Ampartzidis, Ioakeim, Chen, Yutong, Hollfelder, Florian, Boroviak, Thorsten E

“…The early specification and rapid growth of extraembryonic membranes are distinctive hallmarks of primate embryogenesis. These complex tasks are resolved…”
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Transcriptional Dynamics Driving MAMP-Triggered Immunity and Pathogen Effector-Mediated Immunosuppression in Arabidopsis Leaves Following Infection with Pseudomonas syringae pv tomato DC3000 by Lewis, Laura A., Polanski, Krzysztof, de Torres-Zabala, Marta, Jayaraman, Siddharth, Bowden, Laura, Moore, Jonathan, Penfold, Christopher A., Jenkins, Dafyd J., Hill, Claire, Baxter, Laura, Kulasekaran, Satish, Truman, William, Littlejohn, George, Prusinska, Justyna, Mead, Andrew, Steinbrenner, Jens, Hickman, Richard, Rand, David, Wild, David L., Ott, Sascha, Buchanan-Wollaston, Vicky, Smirnoff, Nick, Beynon, Jim, Denby, Katherine, Grant, Murray

“…Transcriptional reprogramming is integral to effective plant defense. Pathogen effectors act transcriptionally and posttranscriptionally to suppress defense…”
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Inferring the perturbation time from biological time course data by Yang, Jing, Penfold, Christopher A, Grant, Murray R, Rattray, Magnus

“…Time course data are often used to study the changes to a biological process after perturbation. Statistical methods have been developed to determine whether…”
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