Search Results - "Pendse, Salil N."

Development and Application of a Life-Stage Physiologically Based Pharmacokinetic (PBPK) Model to the Assessment of Internal Dose of Pyrethroids in Humans by Mallick, Pankajini, Moreau, Marjory, Song, Gina, Efremenko, Alina Y, Pendse, Salil N, Creek, Moire R, Osimitz, Thomas G, Hines, Ronald N, Hinderliter, Paul, Clewell, Harvey J, Lake, Brian G, Yoon, Miyoung

“…Abstract To address concerns around age-related sensitivity to pyrethroids, a life-stage physiologically based pharmacokinetic (PBPK) model, supported by in…”
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Considerations for Improving Metabolism Predictions for In Vitro to In Vivo Extrapolation by Moreau, Marjory, Mallick, Pankajini, Smeltz, Marci, Haider, Saad, Nicolas, Chantel I, Pendse, Salil N, Leonard, Jeremy A, Linakis, Matthew W, McMullen, Patrick D, Clewell, Rebecca A, Clewell, Harvey J, Yoon, Miyoung

“…High-throughput (HT) to extrapolation (IVIVE) is an integral component in new approach method (NAM)-based risk assessment paradigms, for rapidly translating…”
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RNA-sequencing (transcriptomic) data collected in liver and lung of male and female B6C3F1 mice exposed to various dose levels of 4-methylimidazole for 2, 5, or 28 days by Black, Michael B., Andersen, Melvin E., Pendse, Salil N., Borghoff, Susan J., Streicker, Michael, McMullen, Patrick D.

“…The National Toxicology Program (NTP) reported that chronic exposure to varying dietary concentrations of 4-methylimidazole (4-MeI) increased lung tumors in…”
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Physiologically‐based pharmacokinetic modelling to predict intragastric rifabutin concentrations in the treatment of Helicobacter pylori infection by Howden, Colin W., Shah, Shailja, Pendse, Salil N., Offman, Elliot, Almenoff, June S., Sheldon, Kely L.

“…Summary Background Sustained intragastric antibiotic exposure is important for Helicobacter pylori eradication, yet little is known about gastric pharmacology…”
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The Human Toxome Collaboratorium: A Shared Environment for Multi-Omic Computational Collaboration within a Consortium by Fasani, Rick A, Livi, Carolina B, Choudhury, Dipanwita R, Kleensang, Andre, Bouhifd, Mounir, Pendse, Salil N, McMullen, Patrick D, Andersen, Melvin E, Hartung, Thomas, Rosenberg, Michael

“…The Human Toxome Project is part of a long-term vision to modernize toxicity testing for the 21st century. In the initial phase of the project, a consortium of…”
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Information-dependent enrichment analysis reveals time-dependent transcriptional regulation of the estrogen pathway of toxicity by Pendse, Salil N., Maertens, Alexandra, Rosenberg, Michael, Roy, Dipanwita, Fasani, Rick A., Vantangoli, Marguerite M., Madnick, Samantha J., Boekelheide, Kim, Fornace, Albert J., Odwin, Shelly-Ann, Yager, James D., Hartung, Thomas, Andersen, Melvin E., McMullen, Patrick D.

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S1417 RHB-105 Q8H Rifabutin Dosing Provides Favorable Exposure for Helicobacter pylori Eradication by Howden, Colin W., Pendse, Salil N., Bush, Mark A., Almenoff, June S., Sheldon, Kely L.

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Using exposure prediction tools to link exposure and dosimetry for risk-based decisions: A case study with phthalates by Moreau, Marjory, Leonard, Jeremy, Phillips, Katherine A., Campbell, Jerry, Pendse, Salil N., Nicolas, Chantel, Phillips, Martin, Yoon, Miyoung, Tan, Yu-Mei, Smith, Sherrie, Pudukodu, Harish, Isaacs, Kristin, Clewell, Harvey

“…A few different exposure prediction tools were evaluated for use in the new in vitro-based safety assessment paradigm using di-2-ethylhexyl phthalate (DEHP)…”
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Identifying qualitative differences in PPARα signaling networks in human and rat hepatocytes and their significance for next generation chemical risk assessment methods by McMullen, Patrick D., Bhattacharya, Sudin, Woods, Courtney G., Pendse, Salil N., McBride, Mary T., Soldatow, Valerie Y., Deisenroth, Chad, LeCluyse, Edward L., Clewell, Rebecca A., Andersen, Melvin E.

“…In this paper, we evaluate the PPARα signaling network in rats, examining transcriptional responses in primary hepatocytes exposed to a PPARα specific ligand,…”
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Addressing systematic inconsistencies between in vitro and in vivo transcriptomic mode of action signatures by McMullen, Patrick D., Pendse, Salil N., Black, Michael B., Mansouri, Kamel, Haider, Saad, Andersen, Melvin E., Clewell, Rebecca A.

“…Because of their broad biological coverage and increasing affordability transcriptomic technologies have increased our ability to evaluate cellular response to…”
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Assessing molecular initiating events (MIEs), key events (KEs) and modulating factors (MFs) for styrene responses in mouse lungs using whole genome gene expression profiling following 1-day and multi-week exposures by Andersen, Melvin E., Cruzan, George, Black, Michael B., Pendse, Salil N., Dodd, Darol, Bus, James S., Sarang, Satinder S., Banton, Marcy I., Waites, Robbie, McMullen, Patrick D.

“…Styrene increased lung tumors in mice at chronic inhalation exposures of 20ppm and greater. MIEs, KEs and MFs were examined using gene expression in three…”
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Physiologically Based Pharmacokinetic Modeling in Risk Assessment: Case Study With Pyrethroids by Mallick, Pankajini, Song, Gina, Efremenko, Alina Y, Pendse, Salil N, Creek, Moire R, Osimitz, Thomas G, Hines, Ronald N, Hinderliter, Paul, Clewell, Harvey J, Lake, Brian G, Yoon, Miyoung, Moreau, Marjory

“…Abstract The assessment of potentially sensitive populations is an important application of risk assessment. To address the concern for age-related sensitivity…”
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Developing context appropriate toxicity testing approaches using new alternative methods (NAMs) by Andersen, Melvin E, McMullen, Patrick D, Phillips, Martin B, Yoon, Miyoung, Pendse, Salil N, Clewell, Harvey J, Hartman, Jessica K, Moreau, Marjory, Becker, Richard A, Clewell, Rebecca A

“…In the past 10 years, the public, private, and non-profit sectors have found agreement that hazard identification and risk assessment should capitalize on the…”
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Combining transcriptomics and PBPK modeling indicates a primary role of hypoxia and altered circadian signaling in dichloromethane carcinogenicity in mouse lung and liver by Andersen, Melvin E., Black, Michael B., Campbell, Jerry L., Pendse, Salil N., Clewell III, Harvey J., Pottenger, Lynn H., Bus, James S., Dodd, Darol E., Kemp, Daniel C., McMullen, Patrick D.

“…Dichloromethane (DCM) is a lung and liver carcinogen in mice at inhalation exposures≥2000ppm. The modes of action (MOA) of these responses have been attributed…”
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Strain-related differences in mouse lung gene expression over a two-year period of inhalation exposure to styrene: Relevance to human risk assessment by Andersen, Melvin E., Cruzan, George, Black, Michael B., Pendse, Salil N., Dodd, Darol E., Bus, James S., Sarang, Satinder S., Banton, Marcy I., Waites, Robbie, Layko, Debra B., McMullen, Patrick D.

“…Both CD-1 and C57BL/6 wildtype (C57BL/6-WT) mice show equivalent short-term lung toxicity from exposures to styrene, while long-term tumor responses are…”
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Information-dependent enrichment analysis reveals time-dependent transcriptional regulation of the estrogen pathway of toxicity by Pendse, Salil N., Maertens, Alexandra, Rosenberg, Michael, Roy, Dipanwita, Fasani, Rick A., Vantangoli, Marguerite M., Madnick, Samantha J., Boekelheide, Kim, Fornace, Albert J., Odwin, Shelly-Ann, Yager, James D., Hartung, Thomas, Andersen, Melvin E., McMullen, Patrick D.

“…The twenty-first century vision for toxicology involves a transition away from high-dose animal studies to in vitro and computational models (NRC in Toxicity…”
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Assessing bioactivity-exposure profiles of fruit and vegetable extracts in the BioMAP profiling system by Wetmore, Barbara A., Clewell, Rebecca A., Cholewa, Brian, Parks, Bethany, Pendse, Salil N., Black, Michael B., Mansouri, Kamel, Haider, Saad, Berg, Ellen L., Judson, Richard S., Houck, Keith A., Martin, Matthew, Clewell, Harvey J., Andersen, Melvin E., Thomas, Russell S., McMullen, Patrick D.

“…The ToxCast program has generated in vitro screening data on over a thousand chemicals to assess potential disruption of important biological processes and…”
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Editor's Highlight: Screening ToxCast Prioritized Chemicals for PPARG Function in a Human Adipose-Derived Stem Cell Model of Adipogenesis by Foley, Briana, Doheny, Daniel L, Black, Michael B, Pendse, Salil N, Wetmore, Barbara A, Clewell, Rebecca A, Andersen, Melvin E, Deisenroth, Chad

“…The developmental origins of obesity hypothesis posits a multifaceted contribution of factors to the fetal origins of obesity and metabolic disease. Adipocyte…”
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Tu1077: PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODEL TO ESTIMATE INTRAGASTRIC RIFABUTIN CONCENTRATIONS FOLLOWING RIFABUTIN 50 MG Q8H (RHB-105) OR 150 MG QD: MORE FAVORABLE EXPOSURE FOR HELICOBACTER PYLORI ERADICATON WITH Q8H DOSING by Howden, Colin W., Pendse, Salil N., Bush, Mark A., Almenoff, June S., Sheldon, Kely L.

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Population Life-course exposure to health effects model (PLETHEM): An R package for PBPK modeling by Pendse, Salil N., Efremenko, Alina, Hack, C. Eric, Moreau, Marjory, Mallick, Pankajini, Dzierlenga, Michael, Nicolas, Chantel I., Yoon, Miyoung, Clewell, Harvey J., McMullen, Patrick D.

“…An outstanding challenge in the acceptance of alternatives to animal testing is the systematic incorporation of computational models into decision making…”
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