Search Results - "Pendri, Annapurna"

Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers by Gerritz, Samuel W, Cianci, Christopher, Kim, Sean, Pearce, Bradley C, Deminie, Carol, Discotto, Linda, McAuliffe, Brian, Minassian, Beatrice F, Shi, Shuhao, Zhu, Shirong, Zhai, Weixu, Pendri, Annapurna, Li, Guo, Poss, Michael A, Edavettal, Suzanne, McDonnell, Patricia A, Lewis, Hal A, Maskos, Klaus, Mörtl, Mario, Kiefersauer, Reiner, Steinbacher, Stefan, Baldwin, Eric T, Metzler, William, Bryson, James, Healy, Matthew D, Philip, Thomas, Zoeckler, Mary, Schartman, Richard, Sinz, Michael, Leyva-Grado, Victor H, Hoffmann, Hans-Heinrich, Langley, David R, Meanwell, Nicholas A, Krystal, Mark

“…Influenza nucleoprotein (NP) plays multiple roles in the virus life cycle, including an essential function in viral replication as an integral component of the…”
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A novel small molecule inhibitor of hepatitis C virus entry by Baldick, Carl J, Wichroski, Michael J, Pendri, Annapurna, Walsh, Ann W, Fang, Jie, Mazzucco, Charles E, Pokornowski, Kevin A, Rose, Ronald E, Eggers, Betsy J, Hsu, Mayla, Zhai, Weixu, Zhai, Guangzhi, Gerritz, Samuel W, Poss, Michael A, Meanwell, Nicholas A, Cockett, Mark I, Tenney, Daniel J

“…Small molecule inhibitors of hepatitis C virus (HCV) are being developed to complement or replace treatments with pegylated interferons and ribavirin, which…”
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Biochemical and behavioral effects of PDE10A inhibitors: Relationship to target site occupancy by Li, Yu-Wen, Seager, Matthew A., Wojcik, Trevor, Heman, Karen, Molski, Thaddeus F., Fernandes, Alda, Langdon, Shaun, Pendri, Annapurna, Gerritz, Samuel, Tian, Yuan, Hong, Yang, Gallagher, Lizbeth, Merritt, James R., Zhang, Chongwu, Westphal, Ryan, Zaczek, Robert, Macor, John E., Bronson, Joanne J., Lodge, Nicholas J.

“…Phosphodiesterase 10A (PDE10A) inhibitors increase the functionality of striatal medium spiny neurons and produce antipsychotic-like effects in rodents by…”
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20-O-Acylcamptothecin Derivatives:  Evidence for Lactone Stabilization by Zhao, Hong, Lee, Chyi, Sai, Prakash, Choe, Yun H, Boro, Michelle, Pendri, Annapurna, Guan, Shuiyun, Greenwald, Richard B

“…Convincing UV and NMR spectrophotometric evidence is presented which demonstrates that at physiological pH, 7.4, 20-O-acyl derivatives of camptothecin (CPT)…”
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General Procedure for Acylation of 3° Alcohols:  Scandium Triflate/DMAP Reagent by Zhao, Hong, Pendri, Annapurna, Greenwald, Richard B

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Drug Delivery Systems:  Water Soluble Taxol 2‘-Poly(ethylene glycol) Ester ProdrugsDesign and in Vivo Effectiveness by Greenwald, Richard B, Gilbert, Carl W, Pendri, Annapurna, Conover, Charles D, Xia, Jing, Martinez, Anthony

“…Water soluble 2‘-taxol poly(ethylene glycol) (PEG) esters have been synthesized and shown to function in vitro as prodrugs. However, in vivo experiments…”
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Highly Water Soluble Taxol Derivatives: 7-Polyethylene Glycol Carbamates and Carbonates by Greenwald, Richard B, Pendri, Annapurna, Bolikal, Durgadas

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Drug delivery of anticancer agents: water soluble 4-poly (ethylene glycol) derivatives of the lignan, podophyllotoxin by Greenwald, Richard B, Conover, Charles D, Pendri, Annapurna, Choe, Yun H, Martinez, Anthony, Wu, Dechun, Guan, Shuiyun, Yao, Zuliang, Shum, Kwok L

“…This paper reports on the synthesis and in vivo oncolytic activity of a series of water-soluble acyl derivatives of polyethylene glycol (PEG) conjugated…”
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PEG Thiazolidine-2-thione, a Novel Reagent for Facile Protein Modification:  Conjugation of Bovine Hemoglobin by Greenwald, Richard B, Pendri, Annapurna, Martinez, Anthony, Gilbert, Carl, Bradley, Patricia

“…A novel PEG linker that employs a thiazolidine-2-thione group has been synthesized. Kinetic studies done on this compound demonstrate a relatively long…”
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Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV‑1 Integrase Inhibitors by Li, Guo, Meanwell, Nicholas A, Krystal, Mark R, Langley, David R, Naidu, B. Narasimhulu, Sivaprakasam, Prasanna, Lewis, Hal, Kish, Kevin, Khan, Javed A, Ng, Alicia, Trainor, George L, Cianci, Christopher, Dicker, Ira B, Walker, Michael A, Lin, Zeyu, Protack, Tricia, Discotto, Linda, Jenkins, Susan, Gerritz, Samuel W, Pendri, Annapurna

“…The standard of care for HIV-1 infection, highly active antiretroviral therapy (HAART), combines two or more drugs from at least two classes. Even with the…”
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Structure-based amelioration of PXR transactivation in a novel series of macrocyclic allosteric inhibitors of HIV-1 integrase by Sivaprakasam, Prasanna, Wang, Zhongyu, Meanwell, Nicholas A., Khan, Javed A., Langley, David R., Johnson, Stephen R., Li, Guo, Pendri, Annapurna, Connolly, Timothy P., Gao, Mian, Camac, Daniel M., Klakouski, Cheryl, Zvyaga, Tatyana, Cianci, Christopher, McAuliffe, Brian, Ding, Bo, Discotto, Linda, Krystal, Mark R., Jenkins, Susan, Peese, Kevin M., Narasimhulu Naidu, B.

“…[Display omitted] Previous studies have identified a series of imidazo[1,2-a]pyridine (IZP) derivatives as potent allosteric inhibitors of HIV-1 integrase…”
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New first and second generation inhibitors of human immunodeficiency virus-1 integrase by Pendri, Annapurna, Meanwell, Nicholas A, Peese, Kevin M, Walker, Michael A

“…The use of inhibitors of HIV-1 integrase for treating HIV-1 infection has proven to be very beneficial. Raltegravir, a strand transfer inhibitor, has been…”
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A facile one-step synthesis of 5-chloro-imidazo[1,5- a]quinazoline by microwave irradiation by Li, Guo, Kakarla, Ramesh, Gerritz, Samuel W., Pendri, Annapurna, Ma, Baoqing

“…A new and facile method has been developed for the one-step synthesis of 5-chloro-imidazo[1,5- a]quinazoline by cyclization of N-acylanthranilic acid A with…”
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Evidence for Classical Cholinergic Toxicity Associated with Selective Activation of M1 Muscarinic Receptors by Alt, Andrew, Pendri, Annapurna, Bertekap, Jr, Robert L, Li, Guo, Benitex, Yulia, Nophsker, Michelle, Rockwell, Kristin L, Burford, Neil T, Sum, Chi Shing, Chen, Jing, Herbst, John J, Ferrante, Meredith, Hendricson, Adam, Cvijic, Mary Ellen, Westphal, Ryan S, O'Connell, Jonathan, Banks, Martyn, Zhang, Litao, Gentles, Robert G, Jenkins, Susan, Loy, James, Macor, John E

“…The muscarinic acetylcholine receptor subtype 1 (M1) receptors play an important role in cognition and memory, and are considered to be attractive targets for…”
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Cannabinoid CB1 receptor ligand binding and function examined through mutagenesis studies of F200 and S383 by Sitkoff, Doree F., Lee, Ning, Ellsworth, Bruce A., Huang, Qi, Kang, Liya, Baska, RoseAnn, Huang, Yanting, Sun, Chongqing, Pendri, Annapurna, Malley, Mary F., Scaringe, Raymond P., Gougoutas, Jack Z., Reggio, Patricia H., Ewing, William R., Pelleymounter, Mary Ann, Carlson, Kenneth E.

“…The cannabinoid CB1 G protein-coupled receptor has been shown to be a regulator of food consumption and has been studied extensively as a drug target for the…”
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Solid Phase Synthesis of 1,5-Diarylpyrazole-4-carboxamides: Discovery of Antagonists of the CB-1 Receptor by Pendri, Annapurna, Dodd, Dharmpal S, Chen, Jing, Cvijic, Mary Ellen, Kang, Liya, Baska, Rose A, Carlson, Kenneth E, Burford, Neil T, Sun, Chongqing, Ewing, William R, Gerritz, Samuel W

“…We have developed a solid phase synthesis route to 1,5-substituted pyrazole-4-carboxamides with three diversity points aimed at the discovery of new compounds…”
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Discovery of pyrazine carboxamide CB1 antagonists: The introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy of the series by Ellsworth, Bruce A., Wang, Ying, Zhu, Yeheng, Pendri, Annapurna, Gerritz, Samuel W., Sun, Chongqing, Carlson, Kenneth E., Kang, Liya, Baska, Rose A., Yang, Yifan, Huang, Qi, Burford, Neil T., Cullen, Mary Jane, Johnghar, Susan, Behnia, Kamelia, Pelleymounter, Mary Ann, Washburn, William N., Ewing, William R.

“…Structure–activity relationships for a series of pyrazine carboxamide CB1 antagonists are reported. Pharmaceutical properties of the series are improved via…”
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General Procedure for Acylation of 3 degrees Alcohols: Scandium Triflate/DMAP Reagent by Zhao, Hong, Pendri, Annapurna, Greenwald, Richard B.

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A Novel Small Molecule Inhibitor of Hepatitis C Virus Entry: e1001086 by Baldick, Carl J, Wichroski, Michael J, Pendri, Annapurna, Walsh, Ann W, Fang, Jie, Mazzucco, Charles E, Pokornowski, Kevin A, Rose, Ronald E, Eggers, Betsy J, Hsu, Mayla, Zhai, Weixu, Zhai, Guangzhi, Gerritz, Samuel W, Poss, Michael A, Meanwell, Nicholas A, Cockett, Mark I, Tenney, Daniel J

“…Small molecule inhibitors of hepatitis C virus (HCV) are being developed to complement or replace treatments with pegylated interferons and ribavirin, which…”
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Drug Delivery Systems Employing 1,4- or 1,6-Elimination:  Poly(ethylene glycol) Prodrugs of Amine-Containing Compounds by Greenwald, Richard B, Pendri, Annapurna, Conover, Charles D, Zhao, Hong, Choe, Yun H, Martinez, Anthony, Shum, Kwok, Guan, Shuiyun

“…A general methodology for synthesizing poly(ethylene glycol) (PEG) prodrugs of amino-containing compounds has been developed and constitutes the basis for…”
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