Search Results - "Pendin, Diana"

Mitofusin 2: from functions to disease by Filadi, Riccardo, Pendin, Diana, Pizzo, Paola

“…Mitochondria are highly dynamic organelles whose functions are essential for cell viability. Within the cell, the mitochondrial network is continuously…”
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The elusive importance of being a mitochondrial Ca2+ uniporter by Pendin, Diana, Greotti, Elisa, Pozzan, Tullio

“…Abstract The molecular components of the mitochondrial Ca2+ uptake machinery have been only recently identified. In the last months, in addition to the pore…”
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Manipulation of Mitochondria Dynamics Reveals Separate Roles for Form and Function in Mitochondria Distribution by Trevisan, Tatiana, Pendin, Diana, Montagna, Aldo, Bova, Sergio, Ghelli, Anna Maria, Daga, Andrea

“…Mitochondria shape is controlled by membrane fusion and fission mediated by mitofusins, Opa1, and Drp1, whereas mitochondrial motility relies on microtubule…”
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Reduction of endoplasmic reticulum stress attenuates the defects caused by Drosophila mitofusin depletion by Debattisti, Valentina, Pendin, Diana, Ziviani, Elena, Daga, Andrea, Scorrano, Luca

“…Ablation of the mitochondrial fusion and endoplasmic reticulum (ER)-tethering protein Mfn2 causes ER stress, but whether this is just an epiphenomenon of…”
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Homotypic fusion of ER membranes requires the dynamin-like GTPase Atlastin by McNew, James A, Daga, Andrea, Orso, Genny, Pendin, Diana, Liu, Song, Tosetto, Jessica, Moss, Tyler J, Faust, Joseph E, Micaroni, Massimo, Egorova, Anastasia, Martinuzzi, Andrea

“…Establishment and maintenance of proper architecture is essential for endoplasmic reticulum (ER) function. Homotypic membrane fusion is required for ER…”
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A Synthetic Fluorescent Mitochondria‐Targeted Sensor for Ratiometric Imaging of Calcium in Live Cells by Pendin, Diana, Norante, Rosa, De Nadai, Andrea, Gherardi, Gaia, Vajente, Nicola, Basso, Emy, Kaludercic, Nina, Mammucari, Cristina, Paradisi, Cristina, Pozzan, Tullio, Mattarei, Andrea

“…Ca2+ handling by mitochondria is crucial for cell life and the direct measure of mitochondrial Ca2+ concentration in living cells is of pivotal interest…”
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Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling Alzheimer’s disease by Lia, Annamaria, Sansevero, Gabriele, Chiavegato, Angela, Sbrissa, Miriana, Pendin, Diana, Mariotti, Letizia, Pozzan, Tullio, Berardi, Nicoletta, Carmignoto, Giorgio, Fasolato, Cristina, Zonta, Micaela

“…Calcium dynamics in astrocytes represent a fundamental signal that through gliotransmitter release regulates synaptic plasticity and behaviour. Here we present…”
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In vivo Analysis of CRISPR/Cas9 Induced Atlastin Pathological Mutations in Drosophila by Montagna, Aldo, Vajente, Nicola, Pendin, Diana, Daga, Andrea

“…The endoplasmic reticulum (ER) is a highly dynamic network whose shape is thought to be actively regulated by membrane resident proteins. Mutation of several…”
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The effects of ER morphology on synaptic structure and function in Drosophila melanogaster by Summerville, James B, Faust, Joseph F, Fan, Ethan, Pendin, Diana, Daga, Andrea, Formella, Joseph, Stern, Michael, McNew, James A

“…Hereditary spastic paraplegia (HSP) is a set of genetic diseases caused by mutations in one of 72 genes that results in age-dependent corticospinal axon…”
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Characterization of the ER-Targeted Low Affinity Ca2+ Probe D4ER by Greotti, Elisa, Wong, Andrea, Pozzan, Tullio, Pendin, Diana, Pizzo, Paola

“…Calcium ion (Ca2+) is a ubiquitous intracellular messenger and changes in its concentration impact on nearly every aspect of cell life. Endoplasmic reticulum…”
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Dynamic constriction and fission of endoplasmic reticulum membranes by reticulon by Espadas, Javier, Pendin, Diana, Bocanegra, Rebeca, Escalada, Artur, Misticoni, Giulia, Trevisan, Tatiana, Velasco del Olmo, Ariana, Montagna, Aldo, Bova, Sergio, Ibarra, Borja, Kuzmin, Peter I., Bashkirov, Pavel V., Shnyrova, Anna V., Frolov, Vadim A., Daga, Andrea

“…The endoplasmic reticulum (ER) is a continuous cell-wide membrane network. Network formation has been associated with proteins producing membrane curvature and…”
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The Concerted Action of Mitochondrial Dynamics and Positioning: New Characters in Cancer Onset and Progression by Pendin, Diana, Filadi, Riccardo, Pizzo, Paola

“…Mitochondria are dynamic organelles whose morphology and activity are extremely variable, depending on the metabolic state of the cell. In particular, their…”
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Generation and Characterization of a New FRET-Based Ca2+ Sensor Targeted to the Nucleus by Galla, Luisa, Vajente, Nicola, Pendin, Diana, Pizzo, Paola, Pozzan, Tullio, Greotti, Elisa

“…Calcium (Ca2+) exerts a pivotal role in controlling both physiological and detrimental cellular processes. This versatility is due to the existence of a…”
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ER Morphology in the Pathogenesis of Hereditary Spastic Paraplegia by Sonda, Sonia, Pendin, Diana, Daga, Andrea

“…The endoplasmic reticulum (ER) is the most abundant and widespread organelle in cells. Its peculiar membrane architecture, formed by an intricate network of…”
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Optogenetic control of mitochondrial metabolism and Ca2+ signaling by mitochondria-targeted opsins by Tkatch, Tatiana, Greotti, Elisa, Baranauskas, Gytis, Pendin, Diana, Roy, Soumitra, Nita, Luliaoana I., Wettmarshausen, Jennifer, Prigge, Matthias, Yizhar, Ofer, Shirihai, Orian S., Fishman, Daniel, Hershfinkel, Michal, Fleidervish, Ilya A., Perocchi, Fabiana, Pozzan, Tullio, Sekler, Israel

“…Key mitochondrial functions such as ATP production, Ca2+ uptake and release, and substrate accumulation depend on the proton electrochemical gradient (ΔμH⁺)…”
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Microtubules Stabilization by Mutant Spastin Affects ER Morphology and Ca2+ Handling by Vajente, Nicola, Norante, Rosa, Redolfi, Nelly, Daga, Andrea, Pizzo, Paola, Pendin, Diana

“…The endoplasmic reticulum (ER) extends as a network of interconnected tubules and sheet-like structures in eukaryotic cells. ER tubules dynamically change…”
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Familial Alzheimer’s disease presenilin-2 mutants affect Ca2+ homeostasis and brain network excitability by Pendin, Diana, Fasolato, Cristina, Basso, Emy, Filadi, Riccardo, Greotti, Elisa, Galla, Luisa, Gomiero, Chiara, Leparulo, Alessandro, Redolfi, Nelly, Scremin, Elena, Vajente, Nicola, Pozzan, Tullio, Pizzo, Paola

“…Alzheimer’s disease (AD) is the most frequent cause of dementia in the elderly. Few cases are familial (FAD), due to autosomal dominant mutations in…”
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Presenilin-2 and Calcium Handling: Molecules, Organelles, Cells and Brain Networks by Pizzo, Paola, Basso, Emy, Filadi, Riccardo, Greotti, Elisa, Leparulo, Alessandro, Pendin, Diana, Redolfi, Nelly, Rossini, Michela, Vajente, Nicola, Pozzan, Tullio, Fasolato, Cristina

“…Presenilin-2 (PS2) is one of the three proteins that are dominantly mutated in familial Alzheimer’s disease (FAD). It forms the catalytic core of the…”
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Lighting Up Ca2+ Dynamics in Animal Models by Redolfi, Nelly, García-Casas, Paloma, netto, Chiara, Sonda, Sonia, Pizzo, Paola, Pendin, Diana

“…Calcium (Ca2+) signaling coordinates are crucial processes in brain physiology. Particularly, fundamental aspects of neuronal function such as synaptic…”
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GTP-dependent packing of a three-helix bundle is required for atlastin-mediated fusion by Pendin, Diana, Tosetto, Jessica, Moss, Tyler J, Andreazza, Camilla, Moro, Stefano, McNew, James A, Daga, Andrea

“…The mechanisms governing atlastin-mediated membrane fusion are unknown. Here we demonstrate that a three-helix bundle (3HB) within the middle domain is…”
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