Search Results - "Penalva, Luiz O"

Site identification in high-throughput RNA―protein interaction data by UREN, Philip J, BAHRAMI-SAMANI, Emad, BURNS, Suzanne C, MEI QIAO, KARGINOV, Fedor V, HODGES, Emily, HANNON, Gregory J, SANFORD, Jeremy R, PENALVA, Luiz O. F, SMITH, Andrew D

“…Post-transcriptional and co-transcriptional regulation is a crucial link between genotype and phenotype. The central players are the RNA-binding proteins, and…”
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Global signatures of protein and mRNA expression levels by de Sousa Abreu, Raquel, Penalva, Luiz O, Marcotte, Edward M, Vogel, Christine

“…Cellular states are determined by differential expression of the cell's proteins. The relationship between protein and mRNA expression levels informs about the…”
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MicroRNA-16 and MicroRNA-424 Regulate Cell-Autonomous Angiogenic Functions in Endothelial Cells via Targeting Vascular Endothelial Growth Factor Receptor-2 and Fibroblast Growth Factor Receptor-1 by Chamorro-Jorganes, Aránzazu, Araldi, Elisa, Penalva, Luiz O.F, Sandhu, Devraj, Fernández-Hernando, Carlos, Suárez, Yajaira

“…OBJECTIVE—MicroRNAs play key roles in modulating a variety of cellular processes by posttranscriptional regulation of their target genes. Vascular endothelial…”
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Functional genomics analyses of RNA-binding proteins reveal the splicing regulator SNRPB as an oncogenic candidate in glioblastoma by Correa, Bruna R, de Araujo, Patricia Rosa, Qiao, Mei, Burns, Suzanne C, Chen, Chen, Schlegel, Richard, Agarwal, Seema, Galante, Pedro A F, Penalva, Luiz O F

“…Glioblastoma (GBM) is the most common and aggressive type of brain tumor. Currently, GBM has an extremely poor outcome and there is no effective treatment. In…”
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Altered lipid metabolism marks glioblastoma stem and non-stem cells in separate tumor niches by Shakya, Sajina, Gromovsky, Anthony D, Hale, James S, Knudsen, Arnon M, Prager, Briana, Wallace, Lisa C, Penalva, Luiz O F, Brown, H Alex, Kristensen, Bjarne W, Rich, Jeremy N, Lathia, Justin D, Brown, J Mark, Hubert, Christopher G

“…Glioblastoma (GBM) displays marked cellular and metabolic heterogeneity that varies among cellular microenvironments within a tumor. Metabolic targeting has…”
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Sequence signatures and mRNA concentration can explain two-thirds of protein abundance variation in a human cell line by Vogel, Christine, Penalva, Luiz O, de Sousa Abreu, Raquel, Ko, Daijin, Le, Shu-Yun, Shapiro, Bruce A, Burns, Suzanne C, Sandhu, Devraj, Boutz, Daniel R, Marcotte, Edward M

“…Transcription, mRNA decay, translation and protein degradation are essential processes during eukaryotic gene expression, but their relative global…”
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A compendium of RNA-binding motifs for decoding gene regulation by Ray, Debashish, Kazan, Hilal, Cook, Kate B., Weirauch, Matthew T., Najafabadi, Hamed S., Li, Xiao, Gueroussov, Serge, Albu, Mihai, Zheng, Hong, Yang, Ally, Na, Hong, Irimia, Manuel, Matzat, Leah H., Dale, Ryan K., Smith, Sarah A., Yarosh, Christopher A., Kelly, Seth M., Nabet, Behnam, Mecenas, Desirea, Li, Weimin, Laishram, Rakesh S., Qiao, Mei, Lipshitz, Howard D., Piano, Fabio, Corbett, Anita H., Carstens, Russ P., Frey, Brendan J., Anderson, Richard A., Lynch, Kristen W., Penalva, Luiz O. F., Lei, Elissa P., Fraser, Andrew G., Blencowe, Benjamin J., Morris, Quaid D., Hughes, Timothy R.

“…RNA-binding proteins are key regulators of gene expression, yet only a small fraction have been functionally characterized. Here we report a systematic…”
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Riborex: fast and flexible identification of differential translation from Ribo-seq data by Li, Wenzheng, Wang, Weili, Uren, Philip J, Penalva, Luiz O F, Smith, Andrew D

“…Global analysis of translation regulation has recently been enabled by the development of Ribosome Profiling, or Ribo-seq, technology. This approach provides…”
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Impact of the thyroid hormone T3 and its nuclear receptor TRα1 on colon cancer stem cell phenotypes and response to chemotherapies by Giolito, Maria Virginia, Bodoirat, Serguei, La Rosa, Theo, Reslinger, Mathieu, Guardia, Gabriela D. A., Mourtada, Jana, Claret, Leo, Joung, Alain, Galante, Pedro A. F., Penalva, Luiz O. F., Plateroti, Michelina

“…Colorectal cancers (CRCs) are highly heterogeneous and show a hierarchical organization, with cancer stem cells (CSCs) responsible for tumor development,…”
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RNA processing as an alternative route to attack glioblastoma by Marcelino Meliso, Fabiana, Hubert, Christopher G., Favoretto Galante, Pedro A., Penalva, Luiz O.

“…Genomic analyses have become an important tool to identify new avenues for therapy. This is especially true for cancer types with extremely poor outcomes,…”
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The 3' end of the story: deciphering combinatorial interactions that control mRNA fate by Sanford, Jeremy R, Penalva, Luiz O F

“…A new study investigates how microRNAs affect the binding of proteins to RNA…”
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miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling by Dávalos, Alberto, Goedeke, Leigh, Smibert, Peter, Ramírez, Cristina M, Warrier, Nikhil P, Andreo, Ursula, Cirera-Salinas, Daniel, Rayner, Katey, Suresh, Uthra, Pastor-Pareja, José Carlos, Esplugues, Enric, Fisher, Edward A, Penalva, Luiz O.F, Moore, Kathryn J, Suárez, Yajaira, Lai, Eric C, Fernández-Hernando, Carlos

“…Cellular imbalances of cholesterol and fatty acid metabolism result in pathological processes, including atherosclerosis and metabolic syndrome. Recent work…”
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The RNA-Binding Protein Musashi1 Affects Medulloblastoma Growth via a Network of Cancer-Related Genes and Is an Indicator of Poor Prognosis by Vo, Dat T, Subramaniam, Dharmalingam, Remke, Marc, Burton, Tarea L, Uren, Philip J, Gelfond, Jonathan A, de Sousa Abreu, Raquel, Burns, Suzanne C, Qiao, Mei, Suresh, Uthra, Korshunov, Andrey, Dubuc, Adrian M, Northcott, Paul A, Smith, Andrew D, Pfister, Stefan M, Taylor, Michael D, Janga, Sarath C, Anant, Shrikant, Vogel, Christine, Penalva, Luiz O.F

“…Musashi1 (Msi1) is a highly conserved RNA-binding protein that is required during the development of the nervous system. Msi1 has been characterized as a stem…”
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Genomic analyses of early responses to radiation in glioblastoma reveal new alterations at transcription, splicing, and translation levels by Choudhary, Saket, Burns, Suzanne C., Mirsafian, Hoda, Li, Wenzheng, Vo, Dat T., Qiao, Mei, Lei, Xiufen, Smith, Andrew D., Penalva, Luiz O.

“…High-dose radiation is the main component of glioblastoma therapy. Unfortunately, radio-resistance is a common problem and a major contributor to tumor…”
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Genomic analyses reveal broad impact of miR-137 on genes associated with malignant transformation and neuronal differentiation in glioblastoma cells by Tamim, Saleh, Vo, Dat T, Uren, Philip J, Qiao, Mei, Bindewald, Eckart, Kasprzak, Wojciech K, Shapiro, Bruce A, Nakaya, Helder I, Burns, Suzanne C, Araujo, Patricia R, Nakano, Ichiro, Radek, Agnes J, Kuersten, Scott, Smith, Andrew D, Penalva, Luiz O F

“…miR-137 plays critical roles in the nervous system and tumor development; an increase in its expression is required for neuronal differentiation while its…”
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Patient-derived conditionally reprogrammed cells maintain intra-tumor genetic heterogeneity by Correa, Bruna R. S., Hu, Joanna, Penalva, Luiz O. F., Schlegel, Richard, Rimm, David L., Galante, Pedro A. F., Agarwal, Seema

“…Preclinical in vitro models provide an essential tool to study cancer cell biology as well as aid in translational research, including drug target…”
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miR‐124, ‐128, and ‐137 Orchestrate Neural Differentiation by Acting on Overlapping Gene Sets Containing a Highly Connected Transcription Factor Network by Santos, Márcia C. T., Tegge, Allison N., Correa, Bruna R., Mahesula, Swetha, Kohnke, Luana Q., Qiao, Mei, Ferreira, Marco A. R., Kokovay, Erzsebet, Penalva, Luiz O. F.

“…The ventricular‐subventricular zone harbors neural stem cells (NSCs) that can differentiate into neurons, astrocytes, and oligodendrocytes. This process…”
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Proneural and mesenchymal glioma stem cells display major differences in splicing and lncRNA profiles by Guardia, Gabriela D. A., Correa, Bruna R., Araujo, Patricia Rosa, Qiao, Mei, Burns, Suzanne, Penalva, Luiz O. F., Galante, Pedro A. F.

“…Therapy resistance and recurrence in high-grade gliomas are driven by their populations of glioma stem cells (GSCs). Thus, detailed molecular characterization…”
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Antagonism between the RNA-binding protein Musashi1 and miR-137 and its potential impact on neurogenesis and glioblastoma development by Velasco, Mitzli X, Kosti, Adam, Guardia, Gabriela D A, Santos, Marcia C, Tegge, Allison, Qiao, Mei, Correa, Bruna R S, Hernández, Greco, Kokovay, Erzsebet, Galante, Pedro A F, Penalva, Luiz O F

“…RNA-binding proteins (RBPs) and miRNAs are critical gene expression regulators that interact with one another in cooperative and antagonistic fashions. We…”
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Genomic Analyses of Musashi1 Downstream Targets Show a Strong Association with Cancer-related Processes by de Sousa Abreu, Raquel, Sanchez-Diaz, Patricia C., Vogel, Christine, Burns, Suzanne C., Ko, Daijin, Burton, Tarea L., Vo, Dat T., Chennasamudaram, Soudhamini, Le, Shu-Yun, Shapiro, Bruce A., Penalva, Luiz O.F.

“…Musashi1 (Msi1) is a highly conserved RNA-binding protein with pivotal functions in stem cell maintenance, nervous system development, and tumorigenesis…”
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