Search Results - "Pena, Sergio Dj"

Ancestral genomes, sex, and the population structure of Trypanosoma cruzi by de Freitas, Jorge M, Augusto-Pinto, Luiz, Pimenta, Juliana R, Bastos-Rodrigues, Luciana, Gonçalves, Vanessa F, Teixeira, Santuza M R, Chiari, Egler, Junqueira, Angela C V, Fernandes, Octavio, Macedo, Andréa M, Machado, Carlos Renato, Pena, Sérgio D J

“…Acquisition of detailed knowledge of the structure and evolution of Trypanosoma cruzi populations is essential for control of Chagas disease. We profiled 75…”
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VKORC1 polymorphisms in Brazilians: comparison with the Portuguese and Portuguese-speaking Africans and pharmacogenetic implications by Suarez-Kurtz, Guilherme, Amorim, António, Damasceno, Albertino, Hutz, Mara H, de Moraes, Manuel Odorico, Ojopi, Elida B, Pena, Sérgio D J, Perini, Jamila A, Prata, Maria João, Ribeiro-dos-Santos, Andrea, Romano-Silva, Marco A, Teixeira, Daniel, Struchiner, Claudio José

“…The heterogeneity of the Brazilian population renders the extrapolation of pharmacogenomic data derived from well-defined ethnic groups inappropriate. We…”
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Tracing the genomic ancestry of Peruvians reveals a major legacy of pre-Columbian ancestors by Sandoval, Jose R, Salazar-Granara, Alberto, Acosta, Oscar, Castillo-Herrera, Wilder, Fujita, Ricardo, Pena, Sergio D J, Santos, Fabricio R

“…In order to investigate the underlying genetic structure and genomic ancestry proportions of Peruvian subpopulations, we analyzed 551 human samples of 25…”
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Differential tissue tropism of Trypanosoma cruzi strains: an in vitro study by Andrade, Luciana O, Galvão, Lúcia M C, Meirelles, Maria de Nazareth S L, Chiari, Egler, Pena, Sergio D J, Macedo, Andrea M

“…We have previously demonstrated selection favoring the JG strain of Trypanosoma cruzi in hearts of BALB/c mice that were chronically infected with an equal…”
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Evidentiation of Paramyosin (Sm-97) as a modulating antigen on granulomatous hypersensitivity to Schistosoma mansoni eggs by Hirsch, C, Carvalho-Queiroz, C, Franco, G R, Pena, S D, Simpson, A J, Goes, A M

“…A Schistosoma mansoni adult worm anionic fraction (PIII) has previously been shown to protect mice against challenge infection and to reduce pulmonary and…”
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Frequent detection of parental consanguinity in children with developmental disorders by a combined CGH and SNP microarray by Fan, Yao-Shan, Ouyang, Xiaomei, Peng, Jinghong, Sacharow, Stephanie, Tekin, Mustafa, Barbouth, Deborah, Bodamer, Olaf, Yusupov, Roman, Navarrete, Christina, Heller, Ana H, Pena, Sérgio Dj

“…Genomic microarrays have been used as the first-tier cytogenetic diagnostic test for patients with developmental delay/intellectual disability, autism spectrum…”
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Virus-host coevolution: common patterns of nucleotide motif usage in Flaviviridae and their hosts by Lobo, Francisco P, Mota, Bruno E F, Pena, Sérgio D J, Azevedo, Vasco, Macedo, Andréa M, Tauch, Andreas, Machado, Carlos R, Franco, Glória R

“…Virus-host biological interaction is a continuous coevolutionary process involving both host immune system and viral escape mechanisms. Flaviviridae family is…”
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Usefulness of Microsatellite Typing in Population Genetic Studies of Trypanosoma cruzi by Macedo, A M, Pimenta, J R, Aguiar, R S, Melo, A I, Chiari, E, Zingales, B, Pena, S D, Oliveira, R P

“…Through microsatellite analysis of 53 monoclonal populations of Trypanosoma cruzi, we found a remarkable degree of genetic polymorphism with no single…”
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Rapid Detection of Rare Deleterious Variants by Next Generation Sequencing with Optional Microarray SNP Genotype Data by Watson, Christopher M., Crinnion, Laura A., Gurgel-Gianetti, Juliana, Harrison, Sally M., Daly, Catherine, Antanavicuite, Agne, Lascelles, Carolina, Markham, Alexander F., Pena, Sergio D. J., Bonthron, David T., Carr, Ian M.

“…ABSTRACT Autozygosity mapping is a powerful technique for the identification of rare, autosomal recessive, disease‐causing genes. The ease with which this…”
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Trypanosoma cruzi : Genetic Structure of Populations and Relevance of Genetic Variability to the Pathogenesis of Chagas Disease by Macedo, Andréa M, Machado, Carlos R, Oliveira, Riva P, Pena, Sérgio D J

“…Chagas disease, caused by the protozoan Trypanosoma cruzi , has a variable clinical course, ranging from symptomless infection to severe chronic disease with…”
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The Genetic Structure of Human Populations Studied Through Short Insertion‐Deletion Polymorphisms by Bastos‐Rodrigues, Luciana, Pimenta, Juliana R., Pena, Sergio D. J.

“…Summary In a landmark study Rosenberg et al. (2002) analyzed human genome diversity with 377 microsatellites in the HGDP‐CEPH Genome Diversity Panel and…”
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Influence of Genomic Ancestry on the Distribution of SLCO1B1, SLCO1B3 and ABCB1 Gene Polymorphisms among Brazilians by Sortica, Vinicius de A., Ojopi, Elida B., Genro, Júlia P., Callegari-Jacques, Sidia, Ribeiro-dos-Santos, Ândrea, de Moraes, Manoel Odorico, Romano-Silva, Marco A., Pena, Sérgio D. J., Suarez-Kurtz, Guilherme, Hutz, Mara H.

“…:  The frequency distribution of SNPs and haplotypes in the ABCB1, SLCO1B1 and SLCO1B3 genes varies largely among continental populations. This variation can…”
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Erratum: New native South American Y chromosome lineages by Jota, Marilza S, Lacerda, Daniela R, Sandoval, José R, Vieira, Pedro Paulo R, Ohasi, Dominique, Santos-Júnior, José E, Acosta, Oscar, Cuellar, Cinthia, Revollo, Susana, Paz-Y-Miño, Cesar, Fujita, Ricardo, Vallejo, Gustavo A, Schurr, Theodore G, Tarazona-Santos, Eduardo M, Pena, Sergio Dj, Ayub, Qasim, Tyler-Smith, Chris, Santos, Fabrício R

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Color and genomic ancestry in Brazilians: a study with forensic microsatellites by Pimenta, Juliana R, Zuccherato, Luciana W, Debes, Adriana A, Maselli, Luciana, Soares, Rosângela P, Moura-Neto, Rodrigo S, Rocha, Jorge, Bydlowski, Sergio P, Pena, Sérgio D J

“…The population of Brazil, formed by extensive admixture between Amerindians, Europeans and Africans, is one of the most variable in the world. We have recently…”
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Chagas disease: role of parasite genetic variation in pathogenesis by Macedo, Andréa M., Oliveira, Riva P., Pena, Sérgio D.J.

“…Chagas disease, caused by the parasite protozoan Trypanosoma cruzi, is characterised by a variable clinical course, from symptomless cases to severe chronic…”
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Simple and Efficient Identification of Rare Recessive Pathologically Important Sequence Variants from Next Generation Exome Sequence Data by Carr, Ian M., Morgan, Joanne, Watson, Christopher, Melnik, Svitlana, Diggle, Christine P., Logan, Clare V., Harrison, Sally M., Taylor, Graham R., Pena, Sergio D.J., Markham, Alexander F., Alkuraya, Fowzan S., Black, Graeme C.M., Ali, Manir, Bonthron, David T.

“…ABSTRACT Massively parallel (“next generation”) DNA sequencing (NGS) has quickly become the method of choice for seeking pathogenic mutations in rare…”
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The MHC gene region of murine hosts influences the differential tissue tropism of infecting Trypanosoma cruzi strains by Freitas, Jorge M, Andrade, Luciana O, Pires, Simone F, Lima, Ricardo, Chiari, Egler, Santos, Ricardo R, Soares, Milena, Machado, Carlos R, Franco, Gloria R, Pena, Sergio D J, Macedo, Andrea M

“…We have previously demonstrated that both parasite genetic variability and host genetic background were important in determining the differential tissue…”
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Impact of population admixture on the distribution of the CYP3A53 polymorphism by Suarez-Kurtz, Guilherme, Perini, Jamila A, Bastos-Rodrigues, Luciana, Pena, Sergio D J, Struchiner, Cláudio

“…To compare the effectiveness of self-identified ethnic/color and marker-based biogeographical ancestry classifications in genotyping the CYP3A5*3 polymorphism…”
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The phylogeography of African Brazilians by Gonçalves, Vanessa F, Carvalho, Cláudia M B, Bortolini, Maria Cátira, Bydlowski, Sérgio P, Pena, Sérgio D J

“…Approximately four million Africans were taken as slaves to Brazil, where they interbred extensively with Amerindians and Europeans. We have previously shown…”
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Rapid visualisation of microarray copy number data for the detection of structural variations linked to a disease phenotype by Carr, Ian M, Diggle, Christine P, Khan, Kamron, Inglehearn, Chris, McKibbin, Martin, Bonthron, David T, Markham, Alexander F, Anwar, Rashida, Dobbie, Angus, Pena, Sergio D J, Ali, Manir

“…Whilst the majority of inherited diseases have been found to be caused by single base substitutions, small insertions or deletions (<1Kb), a significant…”
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