Search Results - "Pena, Olga M."

Therapeutic potential of host defense peptides in antibiotic-resistant infections by Afacan, Nicole J, Yeung, Amy T Y, Pena, Olga M, Hancock, Robert E W

“…The emergence of infections caused by multi-drug resistant (MDR) pathogens pose a major burden to modern healthcare. Exacerbating this issue is the substantial…”
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INMEX--a web-based tool for integrative meta-analysis of expression data by Xia, Jianguo, Fjell, Christopher D, Mayer, Matthew L, Pena, Olga M, Wishart, David S, Hancock, Robert E W

“…The widespread applications of various 'omics' technologies in biomedical research together with the emergence of public data repositories have resulted in a…”
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Endotoxin tolerance represents a distinctive state of alternative polarization (M2) in human mononuclear cells by Pena, Olga M, Pistolic, Jelena, Raj, Disha, Fjell, Christopher D, Hancock, Robert E W

“…Classical (M1) and alternative (M2) polarization of mononuclear cells (MNCs) such as monocyte and macrophages is known to occur in response to challenges…”
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Synthetic cationic peptide IDR-1018 modulates human macrophage differentiation by Pena, Olga M, Afacan, Nicole, Pistolic, Jelena, Chen, Carol, Madera, Laurence, Falsafi, Reza, Fjell, Christopher D, Hancock, Robert E W

“…Macrophages play a critical role in the innate immune response. To respond in a rapid and efficient manner to challenges in the micro-environment, macrophages…”
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Dibutyl phthalate modulates phenotype of granulocytes in human blood in response to inflammatory stimuli by Maestre-Batlle, Danay, Pena, Olga M., Huff, Ryan D., Randhawa, Abnashi, Carlsten, Christopher, Bølling, Anette K.

“…•DBP is a plasticizer linked to airway diseases with limited experimental data describing immune-modulating effects.•DBP reduced TNFα and IFNγ release and…”
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Host defense peptide LL-37 selectively reduces proinflammatory macrophage responses by Brown, Kelly L, Poon, Grace F T, Birkenhead, Darlene, Pena, Olga M, Falsafi, Reza, Dahlgren, Claes, Karlsson, Anna, Bylund, Johan, Hancock, Robert E W, Johnson, Pauline

“…The human cathelicidin peptide, LL-37, is a host defense peptide with a wide range of immunomodulatory activities and modest direct antimicrobial properties…”
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INVEX--a web-based tool for integrative visualization of expression data by Xia, Jianguo, Lyle, Ngan H, Mayer, Matthew L, Pena, Olga M, Hancock, Robert E W

“…Gene expression or metabolomics data generated from clinical settings are often associated with multiple metadata (i.e. diagnosis, genotype, gender, etc.). It…”
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Barriers to the effective treatment of sepsis: antimicrobial agents, sepsis definitions, and host-directed therapies by Lyle, Ngan H., Pena, Olga M., Boyd, John H., Hancock, Robert E. W.

“…Sepsis is a complex clinical syndrome involving both infection and a deleterious host immune response. Antimicrobial agents are key elements of sepsis…”
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An Endotoxin Tolerance Signature Predicts Sepsis and Organ Dysfunction at Initial Clinical Presentation by Pena, Olga M., Hancock, David G., Lyle, Ngan H., Linder, Adam, Russell, James A., Xia, Jianguo, Fjell, Christopher D., Boyd, John H., Hancock, Robert E.W.

“…Sepsis involves aberrant immune responses to infection, but the exact nature of this immune dysfunction remains poorly defined. Bacterial endotoxins like…”
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Critical Role of Plasmacytoid Dendritic Cells in Regulating Gene Expression and Innate Immune Responses to Human Rhinovirus-16 by Xi, Yang, Troy, Niamh M, Anderson, Denise, Pena, Olga M, Lynch, Jason P, Phipps, Simon, Bosco, Anthony, Upham, John W

“…Though human rhinoviruses (HRVs) are usually innocuous viruses, they can trigger serious consequences in certain individuals, especially in the setting of…”
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Requirement of the Pseudomonas aeruginosa CbrA Sensor Kinase for Full Virulence in a Murine Acute Lung Infection Model by Yeung, Amy T Y, Janot, Laure, Pena, Olga M, Neidig, Anke, Kukavica-Ibrulj, Irena, Hilchie, Ashley, Levesque, Roger C, Overhage, Joerg, Hancock, Robert E W

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Host defense peptides: front-line immunomodulators by Mansour, Sarah C, Pena, Olga M, Hancock, Robert E.W

“…Highlights • The most relevant biological role of host defense peptides is immunomodulation. • These immunomodulatory functions are therapeutic in several…”
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Predicting sepsis severity at first clinical presentation: The role of endotypes and mechanistic signatures by Baghela, Arjun, Pena, Olga M., Lee, Amy H., Baquir, Beverlie, Falsafi, Reza, An, Andy, Farmer, Susan W., Hurlburt, Andrew, Mondragon-Cardona, Alvaro, Rivera, Juan Diego, Baker, Andrew, Trahtemberg, Uriel, Shojaei, Maryam, Jimenez-Canizales, Carlos Eduardo, dos Santos, Claudia C., Tang, Benjamin, Bouma, Hjalmar R., Cohen Freue, Gabriela V., Hancock, Robert E.W.

“…Inter-individual variability during sepsis limits appropriate triage of patients. Identifying, at first clinical presentation, gene expression signatures that…”
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Novel flow cytometry approach to identify bronchial epithelial cells from healthy human airways by Maestre-Batlle, Danay, Pena, Olga M., Hirota, Jeremy A., Gunawan, Evelyn, Rider, Christopher F., Sutherland, Darren, Alexis, Neil E., Carlsten, Chris

“…Sampling various compartments within the lower airways to examine human bronchial epithelial cells (HBEC) is essential for understanding numerous lung…”
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Airway cells from protracted bacterial bronchitis and bronchiectasis share similar gene expression profiles by Chen, Alice C.‐H., Pena, Olga M., Nel, Hendrik J., Yerkovich, Stephanie T., Chang, Anne B., Baines, Katherine J., Gibson, Peter G., Petsky, Helen L., Pizzutto, Susan J., Hodge, Sandra, Masters, Ian B., Buntain, Helen L., Upham, John W.

“…Aim Protracted bacterial bronchitis (PBB) is a common cause of prolonged cough in young children, and may be a precursor of bronchiectasis. Bacteria are often…”
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Mutation and polymorphism spectrum of the GALNS gene in mucopolysaccharidosis IVA (Morquio A) by Tomatsu, Shunji, Montaño, Adriana M., Nishioka, Tatsuo, Gutierrez, Monica A., Peña, Olga M., Tranda firescu, Georgeta G., Lopez, Patricia, Yamaguchi, Seiji, Noguchi, Akihiko, Orii, Tadao

“…Mucopolysaccharidosis IVA (MPS IVA; Morquio A disease) is an autosomal‐recessive disorder caused by a deficiency of lysosomal N‐acetylgalactosamine‐6‐sulfate…”
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Development of MPS IVA mouse (Galnstm(hC79S·mC76S)slu) tolerant to human N-acetylgalactosamine-6-sulfate sulfatase by Tomatsu, Shunji, Gutierrez, Monica, Nishioka, Tatsuo, Yamada, Masamichi, Yamada, Mana, Tosaka, Yasuhiro, Grubb, Jeffrey H., Montaño, Adriana M., Vieira, Matheus B., Trandafirescu, Georgeta G., Peña, Olga M., Yamaguchi, Seiji, Orii, Koji O., Orii, Tadao, Noguchi, Akihiko, Laybauer, Leticia

“…Mucopolysaccharidosis IVA (MPS IVA) is an autosomal recessive disease caused by N-acetylgalactosamine-6-sulfate sulfatase (GALNS) deficiency. In recent studies…”
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Systems biology approaches to understand sepsis by Pena, Olga M., Fjell, Christopher D., Raj, Disha, Lynn, David, Hancock, Robert

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Exploring the development of endotoxin tolerance and anti-endotoxin activity of LL-37 in mammalian cells (134.55) by Pena (Serrato), Olga M, Pistolic, Jelena, Falsafi, Reza, Gardy, Jennifer, Hancock, Robert E. W.

“…Abstract The innate immune response is the first line of defense against microorganisms. However, its over-stimulation can result in excessive inflammation…”
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