Search Results - "Pemble, S"

Theta, a new class of glutathione transferases purified from rat and man by MEYER, D. J, COLES, B, PEMBLE, S. E, GILMORE, K. S, FRASER, G. M, KETTERER, B

“…Glutathione transferases (GSTs) of a novel class, which it is proposed to term Theta, were purified from rat and human liver. Two, named GST 5-5 and GST 12-12,…”
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NEONATAL HYPOTONIA CAN BE A SODIUM CHANNELOPATHY : RECOGNITION OF A NEW PHENOTYPE by MATTHEWS, E, GUET, A, MAYER, M, VICART, S, PEMBLE, S, STERNBERG, D, FONTAINE, B, HANNA, M. G

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An evolutionary perspective on glutathione transferases inferred from class-Theta glutathione transferase cDNA sequences by PEMBLE, S. E, TAYLOR, J. B

“…We report the cDNA sequence for rat glutathione transferase (GST) subunit 5, which is one of at least three class Theta subunits in this species. This…”
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Human glutathione S-transferase theta (GSTT1) : cDNA cloning and the characterization of a genetic polymorphism by PEMBLE, S, SCHROEDER, K. R, SPENCER, S. R, MEYER, D. J, HALLIER, E, BOLT, H. M, KETTERER, B, TAYLOR, J. B

“…In humans, glutathione-dependent conjugation of halomethanes is polymorphic, with 60% of the population classed as conjugators and 40% as non-conjugators. We…”
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Gene deletion of glutathione S-transferase theta: correlation with induced genetic damage and potential role in endogenous mutagenesis by Wiencke, J K, Pemble, S, Ketterer, B, Kelsey, K T

“…Genetic traits that confer increased susceptibility to DNA and chromosomal damage from reactive epoxide and peroxides could be important individual risk…”
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Expression of Mammalian Glutathione S-Transferase 5-5 in Salmonella typhimurium TA1535 Leads to Base-Pair Mutations Upon Exposure to Dihalomethanes by Thier, Ricarda, Taylor, John B., Pemble, Sally E., Humphreys, W. Griffith, Persmark, Magnus, Ketterer, Brian, Guengerich, F. Peter

“…Dihalomethanes can produce liver tumors in mice but not in rats, and concern exists about the risk of these compounds to humans. Glutathione (GSH) conjugation…”
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Human glutathione S-transferase T1-1 enhances mutagenicity of 1,2-dibromoethane, dibromomethane and 1,2,3,4-diepoxybutane in Salmonella typhimurium by THIER, R, PEMBLE, S. E, KRAMER, H, TAYLOR, J. B, GUENGERICH, F. P, KETTERER, B

“…The rat theta class glutathione S-transferase (GST) 5-5 has been shown to affect the mutagenicity of halogenated alkanes and epoxides. In Salmonella…”
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Glutathione S-transferase class Kappa: characterization by the cloning of rat mitochondrial GST and identification of a human homologue by Pemble, S E, Wardle, A F, Taylor, J B

“…We have isolated a cDNA clone that encodes rat glutahione S-transferase (GST) subunit 13, a GST originally isolated from rat liver mitochondrial matrix by…”
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The Human Glutathione S-Transferase Supergene Family, Its Polymorphism, and Its Effects on Susceptibility to Lung Cancer by Ketterer, Brian, Harris, Jonathan M., Talaska, Glen, Meyer, David J., Pemble, Sally E., Taylor, John B., Lang, Nicholas P., Kadlubar, Fred F.

“…Cytosolic glutathione S-transferases (GSTs) are a supergene family of dimeric enzymes capable of detoxifying a number of carcinogenic electrophiles. Of the…”
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D.P.2.13 Neonatal hypotonia can be a sodium channelopathy by Matthews, E, Guet, A, Mayer, M, Vicart, S, Pemble, S, Sternberg, D, Fontaine, B, Hanna, M.G

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Cloning and heterologous expression of cDNA encoding class alpha rat glutathione transferase 8-8, an enzyme with high catalytic activity towards genotoxic α,β-unsaturated carbonyl compounds by STENBERG, G, RIDDERSTRÖM, M, ENGSTRÖM, A, PEMBLE, S. E, MANNERVIK, B

“…A cDNA clone, lambda GTRA8, encoding rat glutathione transferase subunit 8 has been isolated from a lambda gt10 rat hepatoma cDNA library. The previously known…”
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The structure of the human glutathione S-transferase pi gene by Cowell, I G, Dixon, K H, Pemble, S E, Ketterer, B, Taylor, J B

“…The human glutathione S-transferase pi gene has been isolated from a cosmid library. The gene spans approximately 3 kb, is interrupted by six introns and the…”
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Structure of human glutathione S-transferase class Mu genes by TAYLOR, J. B, OLIVER, J, SHERRINGTON, R, PEMBLE, S. E

“…Nucleotide sequencing of a human cosmid clone shows that the exon-intron structures of a glutathione S-transferase multigene family are conserved between man…”
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The glutathione transferase activity and tissue distribution of a cloned Mr28K protective antigen of Schistosoma mansoni by Taylor, J. B., Vidal, A., Torpier, G., Meyer, D. J., Roitsch, C., Balloul, J. M., Southan, C., Sondermeyer, P., Pemble, S., Lecocq, J. P.

“…A protective Mr28K antigen of Schistosoma mansoni, expressed from its cDNA, has been purified in a single step and shown to possess glutathione (GSH)…”
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Glutathione transferase pi its minimal promoter and downstream cis-acting element by Xia, C L, Cowell, I G, Dixon, K H, Pemble, S E, Ketterer, B, Taylor, J B

“…Fragments of the human glutathione S-transferase pi gene and 15 kb of its 5' flanking region have been fused to the chloramphenicol acetyl transferase (CAT)…”
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Tissue distribution of rat glutathione transferase subunit 7, a hepatoma marker by Pemble, S E, Taylor, J B, Ketterer, B

“…Polyadenylated RNA isolated from NN-dimethyl-4-aminoazobenzene-induced rat hepatoma was used to prepare a cDNA library in lambda gt10. Full-length clones…”
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Control of expression of the human glutathione S-transferase pi gene differs from its rat orthologue by Dixon, K H, Cowell, I G, Xia, C L, Pemble, S E, Ketterer, B, Taylor, J B

“…We have examined regulation of the glutathione S-transferase pi gene by transient expression assay, and find that a fragment from 8 to 99 bp upstream of the…”
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The human mitochondrial NADH: ubiquinone oxidoreductase 51-kDa subunit maps adjacent to the glutathione S-transferase P1-1 gene on chromosome 11q13 by Spencer, S R, Taylor, J B, Cowell, I G, Xia, C L, Pemble, S E, Ketterer, B

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Enhancement of Bacterial Mutagenicity of Bifunctional Alkylating Agents by Expression of Mammalian Glutathione S-Transferase by Thier, Ricarda, Muller, Michael, Taylor, John B, Pemble, Sally E, Ketterer, Brian, Guengerich, F. Peter

“…Recently, we inserted the plasmid vector pKK233-2 containing rat GSH S-transferase (GST) 5-5 cDNA into Salmonella typhimurium TA1535 and found that these…”
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Changes in expression of mRNA coding for glutathione S-transferase subunits 1-2 and 7 in cultured rat hepatocytes by Vandenberghe, Y, Morel, F, Pemble, S, Taylor, J B, Rogiers, V, Ratanasavanh, D, Vercruysse, A, Ketterer, B, Guillouzo, A

“…mRNA hybridizing to probes for glutathione S-transferase (GST) subunits 1 and 2 (probe pGSTr 155) and subunit 7 (probe pGSTr 7) has been measured by Northern…”
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