Search Results - "Pemberton, P A"

maspin Suppresses the invasive phenotype of human breast carcinoma by SEFTOR, R. E. B, SEFTOR, E. A, SHIJIE SHENG, PEMBERTON, P. A, SAGER, R, HENDRIX, M. J. C

“…The recently discovered tumor suppressor gene maspin has been shown to inhibit tumor cell motility, invasion, and metastasis in breast cancer by our…”
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Phase I study of bryostatin 1 in patients with relapsed non-Hodgkin's lymphoma and chronic lymphocytic leukemia by Varterasian, M L, Mohammad, R M, Eilender, D S, Hulburd, K, Rodriguez, D H, Pemberton, P A, Pluda, J M, Dan, M D, Pettit, G R, Chen, B D, Al-Katib, A M

“…To define, in a phase I study in relapsed non-Hodgkin's lymphoma (NHL) and chronic lymphocytic leukemia (CLL), the maximum-tolerated dose (MTD), major…”
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Hormone binding globulins undergo serpin conformational change in inflammation by Pemberton, P. A, Stein, P. E, Pepys, M. B, Potter, J. M, Carrell, R. W

“…A surprising recent finding is that thyroxine binding globulin (TBG) and cortisol binding globulin (CBG), are members of the serine protease inhibitor (serpin)…”
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Production, purification, and characterization of recombinant maspin proteins by Sheng, S, Pemberton, P A, Sager, R

“…Maspin, a novel mammary serine protease inhibitor, was shown to have tumor suppressing activity (Zou, Z., Anisowicz, A., Hendrix, M. J. C., Thor, A., Neveu,…”
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The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature by Silverman, G A, Bird, P I, Carrell, R W, Church, F C, Coughlin, P B, Gettins, P G, Irving, J A, Lomas, D A, Luke, C J, Moyer, R W, Pemberton, P A, Remold-O'Donnell, E, Salvesen, G S, Travis, J, Whisstock, J C

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The serpins: evolution and adaptation in a family of protease inhibitors by Carrell, R W, Pemberton, P A, Boswell, D R

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Interaction of subtilisins with serpins by Komiyama, Tomoko, Grøn, Hanne, Salvesen, Guy S., Pemberton, Philip A.

“…Serpins are well‐characterized inhibitors of the chymotrypsin family serine proteinases. We have investigated the interaction of two serpins with members of…”
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Cross-Class Inhibition of the Cysteine Proteinases Cathepsins K, L, and S by the Serpin Squamous Cell Carcinoma Antigen 1:  A Kinetic Analysis by Schick, Charles, Pemberton, Philip A, Shi, Guo-Ping, Kamachi, Yoshiro, Çataltepe, Sule, Bartuski, Allison J, Gornstein, Eric R, Brömme, Dieter, Chapman, Harold A, Silverman, Gary A

“…The human squamous cell carcinoma antigens (SCCA) 1 and 2 are tandemly arrayed genes that encode two high-molecular-weight serine proteinase inhibitors…”
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The structural basis for neutrophil inactivation of C1 inhibitor by Pemberton, P A, Harrison, R A, Lachmann, P J, Carrell, R W

“…Limited proteolysis of C1 inhibitor (C1-INH) by neutrophil elastase, Pseudomonas elastase and snake venoms resulted in initial cleavage within the molecule's…”
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Antiapoptotic Activity of the Bowman-Birk Inhibitor Can Be Attributed to Copurified Phospholipids by Foehr, Matthew W., Tomei, L. David, Goddard, J. Graham, Pemberton, Philip A., Bathurst, Ian C.

“…Previous studies have shown that extracts from soy possess potent antiapoptotic activity in in vitro and in vivo models. We recently reported that this…”
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Squamous Cell Carcinoma Antigen 2 Is a Novel Serpin That Inhibits the Chymotrypsin-like Proteinases Cathepsin G and Mast Cell Chymase by Schick, Charles, Kamachi, Yoshiro, Bartuski, Allison J., Çataltepe, Sule, Schechter, Norman M., Pemberton, Philip A., Silverman, Gary A.

“…The squamous cell carcinoma antigen (SCCA) serves as a serological marker for more advanced squamous cell tumors. Molecular cloning of the SCCA genomic region…”
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Soy-derived antiapoptotic fractions protect gastrointestinal epithelium from damage caused by methotrexate treatment in the rat by Logvinova, A.V, Foehr, M.W, Pemberton, P.A, Khazalpour, K.M, Funk-Archuleta, M.A, Bathurst, I.C, Tomei, L.D

“…The ability of a previously described soy-derived antiapoptotic fraction (SDAAF), a soy water extract (Lexirin), and raw soy flour to inhibit methotrexate…”
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Maspin Is an Intracellular Serpin That Partitions into Secretory Vesicles and Is Present at the Cell Surface by Pemberton, Philip A, Tipton, A. Rene, Pavloff, Nadine, Smith, Jason, Erickson, James R, Mouchabeck, Zahi M, Kiefer, Michael C

“…The tumor suppressor maspin (mammary serpin) was originally identified as a component of human mammary epithelial cells that is downregulated as mammary tumor…”
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Phase II Trial of Bryostatin 1 in Patients with Relapsed Low-Grade Non-Hodgkin’s Lymphoma and Chronic Lymphocytic Leukemia by Varterasian, M L, Mohammad, R M, Shurafa, M S, Hulburd, K, Pemberton, P A, Rodriguez, D H, Spadoni, V, Eilender, D S, Murgo, A, Wall, N, Dan, M, Al-Katib, A M

“…Bryostatin 1 is a natural product isolated from the marine bryozoan Bugula neritina in 1982 and is currently undergoing evaluation in a number of malignancies…”
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Molecular cloning and characterization of Porphyromonas gingivalis lysine-specific gingipain. A new member of an emerging family of pathogenic bacterial cysteine proteinases by Pavloff, N, Pemberton, P A, Potempa, J, Chen, W C, Pike, R N, Prochazka, V, Kiefer, M C, Travis, J, Barr, P J

“…The proteinases of Porphyromonas gingivalis are key virulence factors in the etiology and progression of periodontal disease. Previous work in our laboratories…”
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The tumor suppressor maspin does not undergo the stressed to relaxed transition or inhibit trypsin-like serine proteases. Evidence that maspin is not a protease inhibitory serpin by Pemberton, P A, Wong, D T, Gibson, H L, Kiefer, M C, Fitzpatrick, P A, Sager, R, Barr, P J

“…The role of tumor suppressor proteins in the development of malignancy has made the understanding of their molecular mechanisms of action of great importance…”
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Genetic variation of Porphyromonas gingivalis genes encoding gingipains, cysteine proteinases with arginine or lysine specificity by Mikolajczyk-Pawlinska, J, Kordula, T, Pavloff, N, Pemberton, P A, Chen, W C, Travis, J, Potempa, J

“…Porphyromonas gingivalis hemagglutinating cysteine proteinases (gingipains) are considered as important virulence factors in the development of adult…”
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Phase II study of bryostatin 1 in patients with relapsed multiple myeloma by VARTERASIAN, Mary L, PEMBERTON, Pamela A, HULBURD, Kim, RODRIGUEZ, Dorothy H, MURGO, Anthony, AL-KATIB, Ayad M

“…Bryostatin 1, a macrocyclic lactone isolated from the marine bryozoan Bugula neritina, is a protein kinase C (PKC) modulator which has shown both preclinical…”
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Pericapsular Osteotomy of the Ilium for Treatment of Congenital Subluxation and Dislocation of the Hip by PEMBERTON, PAUL A

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Pericapsular osteotomy of the ilium for the treatment of congenitally dislocated hips by Pemberton, P A

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