Search Results - "Pemberton, Alan"

The goblet cell is the cellular source of the anti-microbial angiogenin 4 in the large intestine post Trichuris muris infection by Forman, Ruth A, deSchoolmeester, Matthew L, Hurst, Rebecca J M, Wright, Steven H, Pemberton, Alan D, Else, Kathryn J

“…Mouse angiogenin 4 (Ang4) has previously been described as a Paneth cell-derived antimicrobial peptide important in epithelial host defence in the small…”
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Proteomic identification of interactions between histones and plasma proteins: Implications for cytoprotection by Pemberton, Alan D, Brown, Jeremy K, Inglis, Neil F

“…Extracellular histones released from cells during acute inflammation contribute to organ failure and death in a mouse model of sepsis, and histones are known…”
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Mouse Mast Cell Tryptase mMCP-6 Is a Critical Link between Adaptive and Innate Immunity in the Chronic Phase of Trichinella spiralis Infection by Shin, Kichul, Watts, Gerald F. M, Oettgen, Hans C, Friend, Daniel S, Pemberton, Alan D, Gurish, Michael F, Lee, David M

“…Although the innate immune function of mast cells in the acute phase of parasitic and bacterial infections is well established, their participation in chronic…”
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Strain-specific copy number variation in the intelectin locus on the 129 mouse chromosome 1 by Lu, Zen H, di Domenico, Alex, Wright, Steven H, Knight, Pamela A, Whitelaw, C Bruce A, Pemberton, Alan D

“…C57BL/6J mice possess a single intelectin (Itln) gene on chromosome 1. The function of intelectins is not well understood, but roles have been postulated in…”
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In vitro interactions of extracellular histones with LDL suggest a potential pro-atherogenic role by Pemberton, Alan D, Brown, Jeremy K

“…Nuclear histones have previously been shown to aggregate LDL in vitro, suggestive of a possible pro-atherogenic role. Recent studies indicate that histones are…”
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Genome-wide transcriptomic analysis of intestinal tissue to assess the impact of nutrition and a secondary nematode challenge in lactating rats by Athanasiadou, Spiridoula, Jones, Leigh A, Burgess, Stewart T G, Kyriazakis, Ilias, Pemberton, Alan D, Houdijk, Jos G M, Huntley, John F

“…Gastrointestinal nematode infection is a major challenge to the health and welfare of mammals. Although mammals eventually acquire immunity to nematodes, this…”
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Expulsion of Trichuris muris is associated with increased expression of angiogenin 4 in the gut and increased acidity of mucins within the goblet cell by D'Elia, Riccardo, DeSchoolmeester, Matthew L, Zeef, Leo A H, Wright, Steven H, Pemberton, Alan D, Else, Kathryn J

“…Trichuris muris in the mouse is an invaluable model for infection of man with the gastrointestinal nematode Trichuris trichiura. Three T. muris isolates have…”
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Tissue‐specific expression of mast cell granule serine proteinases and their role in inflammation in the lung and gut by Miller, Hugh R. P., Pemberton, Alan D.

“…Summary Serine proteinases with trypsin‐like (tryptase) and chymotrypsin‐like (chymase) properties are major constituents of mast cell granules. Several…”
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Innate BALB/c Enteric Epithelial Responses to Trichinella spiralis: Inducible Expression of a Novel Goblet Cell Lectin, Intelectin-2, and Its Natural Deletion in C57BL/10 Mice by Pemberton, Alan D, Knight, Pamela A, Gamble, John, Colledge, William H, Lee, Jin-Kyu, Pierce, Michael, Miller, Hugh R. P

“…Infection of mice with the nematode parasite Trichinella spiralis induces changes in the proteome of the jejunal epithelium, including substantial…”
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Oral tolerance induction does not resolve gastrointestinal inflammation in a mouse model of food allergy by Burggraf, Manja, Nakajima-Adachi, Haruyo, Hachimura, Satoshi, Ilchmann, Anne, Pemberton, Alan D, Kiyono, Hiroshi, Vieths, Stefan, Toda, Masako

“…Oral immunotherapy (OIT) involving continuous oral administration of allergenic foods has gained attention as a therapy for food allergies. To study the…”
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Novel gene expression responses in the ovine abomasal mucosa to infection with the gastric nematode Teladorsagia circumcincta by Knight, Pamela A, Griffith, Susan E, Pemberton, Alan D, Pate, Judith M, Guarneri, Lauren, Anderson, Katherine, Talbot, Richard T, Smith, Sarah, Waddington, David, Fell, Mark, Archibald, Alan L, Burgess, Stewart TG, Smith, David W, Miller, Hugh RP, Morrison, Ivan W

“…Infection of sheep with the gastric nematode Teladorsagia circumcincta results in distinct Th2-type changes in the mucosa, including mucous neck cell and mast…”
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A single-nucleotide polymorphism in intelectin 1 is associated with increased asthma risk by Pemberton, Alan D., PhD, Rose-Zerilli, Matthew J., BSc, Holloway, John W., PhD, Gray, Robert D., MD, Holgate, Stephen T., MD, DSc

“…The Val109Asp single-nucleotide polymorphism (SNP; rs2274907) in ITLN1 exon 4 was previously investigated by Schaffler et al,8 who determined that this SNP was…”
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Chronic allergen challenge induces bronchial mast cell accumulation in BALB/c but not C57BL/6 mice and is independent of IL-9 by Pae, Suzan, Cho, Jae Youn, Dayan, Shanna, Miller, Marina, Pemberton, Alan D, Broide, David H

“…As genetically engineered mutant mice deficient in single genes are usually generated on a C57BL/6 background, to study mast cell trafficking in mutant mice,…”
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proteome of gastric lymph in normal and nematode infected sheep by Goldfinch, Gillian M, Smith, W. David, Imrie, Lisa, McLean, Kevin, Inglis, Neil F, Pemberton, Alan D

“…Lymph node cannulation allows the collection of lymph draining from a defined anatomical region. Proteomic analysis of that lymph offers a potentially valuable…”
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NKp46 defines ovine cells that have characteristics corresponding to NK cells by Connelley, Timothy, Storset, Anne K, Pemberton, Alan, MacHugh, Niall, Brown, Jeremy, Lund, Hege, Morrison, Ivan W

“…Natural killer (NK) cells are well recognized as playing a key role in innate immune defence through cytokine production and cytotoxic activity; additionally…”
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Extended cleavage specificity of mMCP-1, the major mucosal mast cell protease in mouse—High specificity indicates high substrate selectivity by Andersson, Mattias K., Pemberton, Alan D., Miller, Hugh R.P., Hellman, Lars

“…Mucosal mast cells are in the mouse predominantly found in the epithelium of the gastrointestinal tract. They express the β-chymases mMCP-1 and mMCP-2. During…”
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Sheep intelectin-2 co-purifies with the mucin Muc5ac from gastric mucus by Pemberton, Alan D., Verdon, Bernard, Inglis, Neil F., Pearson, Jeffrey P.

“…Secretion of gastric mucins plays an essential role in host protection, and modifications in mucus properties are characteristic of the protective immune…”
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Expression of three intelectins in sheep and response to a Th2 environment by FRENCH, Anne T, KNIGHT, Pamela A, SMITH, W. David, PATE, Judith A, MILLER, Hugh R. P, PEMBERTON, Alan D

“…Sheep intelectin1 and sheep intelectin3 (sITLN1 and sITLN3) were cloned and sequenced. The amino acid sequences of sITLN1 and sITLN3 shared 86% and 91%…”
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Changes in protein expression in the sheep abomasum following trickle infection with Teladorsagia circumcincta by Pemberton, Alan D, Brown, Jeremy K, Craig, Nicky M, Pate, Judith, McLean, Kevin, Inglis, Neil F, Knox, David, Knight, Pamela A

“…Continual low-level exposure of sheep to the helminth Teladorsagia circumcincta elicits a temporary protective immunity, where factors in the immune abomasal…”
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Up-regulation of intelectin in sheep after infection with Teladorsagia circumcincta by French, Anne T., Knight, Pamela A., Smith, W. David, Brown, Jeremy K., Craig, Nicola M., Pate, Judith A., Miller, Hugh R.P., Pemberton, Alan D.

“…A novel intelectin molecule designated sheep intelectin 2 (sITLN2) was detected in sheep abomasal mucosa. The full sequence shared 76–83% homology with other…”
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