Search Results - "Pemberton, A. D."

Innate immune response mechanisms in the intestinal epithelium: potential roles for mast cells and goblet cells in the expulsion of adult Trichinella spiralis by Knight, P A, Brown, J K, Pemberton, A D

“…SUMMARYGastrointestinal infection with the nematode Trichinella spiralis is accompanied by a rapid and reversible expansion of the mucosal mast cell and goblet…”
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Organic dust exposure increases mast cell tryptase in bronchoalveolar lavage fluid and airway epithelium of heaves horses by Dacre, K. J., McGorum, B. C., Marlin, D. J., Bartner, L. R., Brown, J. K., Shaw, D. J., Robinson, N. E., Deaton, C., Pemberton, A. D.

“…Summary Background Mast cell degranulation is believed to act as a key event in initiating and maintaining airway response to allergen challenge in human…”
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cDNA cloning and substrate specificity of equine tryptase, a possible mediator in equine heaves by Dacre, K. J., McAleese, S. M., Knight, P., McGorum, B. C., Pemberton, A.D.

“…Summary Background Mast cell mediators are believed to play a central role in inflammatory lung disorders such as human allergic and occupational asthma…”
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Purification and characterization of mouse mast cell proteinase-2 and the differential expression and release of mouse mast cell proteinase-1 and -2 in vivo by Pemberton, A. D., Brown, J. K., Wright, S. H., Knight, P. A., McPhee, M. L., McEuen, A. R., Forse, P. A., Miller, H. R.P.

“…Summary Background Gastrointestinal nematode infection is associated with mucosal mast cell (MMC) hyperplasia. In the mouse, this is accompanied by the release…”
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cDNA sequence of two sheep mast cell tryptases and the differential expression of tryptase and sheep mast cell proteinase-1 in lung, dermis and gastrointestinal tract by PEMBERTON, A. D, MCALEESE, S. M, HUNTLEY, J. F, COLLIE, D. D. S, SCUDAMORE, C. L, MCEUEN, A. R, WALLS, A. F, MILLER, H. R. P

“…Mast cell tryptases are a family of serine proteinases which are implicated in the proliferation of smooth muscle cells and fibroblasts, upregulation of…”
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Local lung responses following local lung challenge with recombinant lungworm antigen in systemically sensitized sheep by Collie, D. D. S., MacAldowie, C. N., Pemberton, A. D., Woodall, C. J., McLean, N., Hodgson, C., Kennedy, M. W., Miller, H. R. P.

“…Background Chronic mast cell‐mediated inflammation may contribute significantly towards the extensive tissue remodelling that is a feature of lungworm…”
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Cloning and molecular modeling of duodenase with respect to evolution of substrate specificity within mammalian serine proteases that have lost a conserved active-site disulfide bond by Zamolodchikova, T S, Smirnova, E V, Andrianov, A N, Kashparov, I V, Kotsareva, O D, Sokolova, E A, Ignatov, K B, Pemberton, A D

“…Mammalian serine proteases such as the chromosome 14 (Homo sapiens, Mus musculus) located granzymes, chymases, cathepsin G, and related enzymes including…”
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Peripheral blood mononuclear cell responses to major and minor Dermatophagoides allergens in canine atopic dermatitis by Nuttall, T.J, Pemberton, A.D, Lamb, J.R, Hill, P.B

“…Atopic dermatitis is a chronic inflammatory and pruritic skin disease commonly seen in dogs and humans. Most cases involve hypersensitivity to the house dust…”
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Transcriptomic analysis of host intestinal tissue to assess the consequences of dietary protein and secondary infection on immunity to nematodes by Athanasiadou, S., Jones, L. A., Burgess, S. T. G., Pemberton, A. D., Kyriazakis, I., Huntley, J. F., Houdijk, J. G. M.

“…Here, we used a genome-wide approach to assess the effects of protein supplementation and secondary infection, on gene expression in the small intestine of…”
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The effect of methadone prescribing in a clinic setting on the criminal activity of drug users by Bates, M, Pemberton, D A

“…The objective was to examine the impact of clinic attendance and methadone prescribing on drug user criminality. Fifty-four consecutive attenders at a Drug…”
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Improved hepatic and pancreatic localisation of the equine alpha-1-proteinase inhibitor family of serpins using an antigen enhancement technique and a monoclonal antibody by Dagleish, M.P., Pemberton, A.D., McAleese, S.M., Thornton, E.M., Miller, H.R.P., Scudamore, C.L.

“…Equine alpha- l-proteinase inhibitor (API) consists of three, occasionally four, serum glycoproteins. This study investigated the immunohistochemical…”
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Retardation of serum albumin migration in native polyacrylamide gel electrophoresis by the incorporation of blue dextran in the gel matrix by Pemberton, A D, John, H A

“…Blue dextran was incorporated into the stacking layer of one-dimensional polyacrylamide gels to prevent the migration of albumin into the resolving gel during…”
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Trypsin stimulates proteinase-activated receptor-2-dependent and -independent activation of mitogen-activated protein kinases by Belham, C M, Tate, R J, Scott, P H, Pemberton, A D, Miller, H R, Wadsworth, R M, Gould, G W, Plevin, R

“…We have examined protease-mediated activation of the mitogen-activated protein (MAP) kinase cascade in rat aortic smooth-muscle cells and bovine pulmonary…”
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Measurement by ELISA of equine alpha-1-proteinase inhibitor in uterine flushings from mares by Scudamore, C L, Pemberton, A D, Miller, H R, McDonnell, A M, Thomson, S R, Dawson, A, Watson, E D

“…An enzyme linked immunosorbent assay (ELISA) was developed and used to estimate the concentrations of the serine proteinase inhibitor, alpha-1 proteinase…”
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Investigation of association between alpha-1 proteinase inhibitor haplotype and endometritis in the thoroughbred mare by Pemberton, A D, John, H A, Ricketts, S W, Rossdale, P D, Scott, A M

“…Failure to inhibit proteinases can lead to excessive tissue damage. The possibility that the severity of endometritis in Thoroughbred mares correlates with the…”
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Quantitation of alpha-1 proteinase inhibitor in the pulmonary epithelial lining fluid of horses with chronic obstructive pulmonary disease by Milne, E M, Pemberton, A D, McGorum, B C, Dixon, P M, Scudamore, C L, Miller, H R

“…The concentration of alpha-1 proteinase inhibitor (API) was measured in the pulmonary epithelial lining fluid (PELF) of horses with chronic obstructive…”
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A comparison of the outcome of treatment in female and male alcoholics by Pemberton, D A

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An improved TLC method for the detection of flunixin in equine serum by Pemberton, A D, Slater, J S, Milne, E M

“…A method for flunixin detection in equine serum extracts involving thin layer chromatography, spraying the chromatogram with alkaline sodium hypochlorite…”
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Characterisation of tryptase and a granzyme H-like chymase isolated from equine mastocytoma tissue by Pemberton, Alan D, McEuen, Alan R, Scudamore, Cheryl L

“…Mast cell proteinases are important inflammatory mediators in man and other species, but until now there has been no investigation of the nature of equine mast…”
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Characterisation of compounds isolated from the sera of horses with acute grass sickness by Pemberton, A D, Hodgson, J C, Gilmour, J S, Doxey, D L

“…Isolates were prepared from the sera of 12 horses with acute grass sickness, using methods reported to yield serum fractions associated with neurotoxicity, and…”
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