Search Results - "Pelz, Nicholas F."

Modular Asymmetric Synthesis of 1,2-Diols by Single-Pot Allene Diboration/Hydroboration/Cross-Coupling by Pelz, Nicholas F, Morken, James P

“…Chiral allyl vinyl boronates are generated by catalytic enantioselective diboration of prochiral allenes. They may then be reacted, in situ, with a…”
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Discovery of 2‑Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods by Pelz, Nicholas F, Bian, Zhiguo, Zhao, Bin, Shaw, Subrata, Tarr, James C, Belmar, Johannes, Gregg, Claire, Camper, DeMarco V, Goodwin, Craig M, Arnold, Allison L, Sensintaffar, John L, Friberg, Anders, Rossanese, Olivia W, Lee, Taekyu, Olejniczak, Edward T, Fesik, Stephen W

“…Myeloid cell leukemia-1 (Mcl-1) is a member of the Bcl-2 family of proteins responsible for the regulation of programmed cell death. Amplification of Mcl-1 is…”
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Discovery of a Potent Inhibitor of Replication Protein A Protein–Protein Interactions Using a Fragment-Linking Approach by Frank, Andreas O, Feldkamp, Michael D, Kennedy, J. Phillip, Waterson, Alex G, Pelz, Nicholas F, Patrone, James D, Vangamudi, Bhavatarini, Camper, DeMarco V, Rossanese, Olivia W, Chazin, Walter J, Fesik, Stephen W

“…Replication protein A (RPA), the major eukaryotic single-stranded DNA (ssDNA)-binding protein, is involved in nearly all cellular DNA transactions. The RPA…”
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Indazoles: Regioselective Protection and Subsequent Amine Coupling Reactions by Slade, David J, Pelz, Nicholas F, Bodnar, Wanda, Lampe, John W, Watson, Paul S

“…Indazoles are unselectively protected under strongly basic conditions to give a mixture at N-1 and N-2. Under mildly acidic conditions, regioselective…”
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Palladium-Catalyzed Enantioselective Diboration of Prochiral Allenes by Pelz, Nicholas F, Woodward, Angela R, Burks, Heather E, Sieber, Joshua D, Morken, James P

“…Pd-catalyzed diboration of prochiral allenes occurs exclusively at the internal position and is remarkably accelerated in the presence of Lewis basic ligand…”
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Identification and Optimization of Anthranilic Acid Based Inhibitors of Replication Protein A by Patrone, James D., Pelz, Nicholas F., Bates, Brittney S., Souza-Fagundes, Elaine M., Vangamudi, Bhavatarini, Camper, Demarco V., Kuznetsov, Alexey G., Browning, Carrie F., Feldkamp, Michael D., Frank, Andreas O., Gilston, Benjamin A., Olejniczak, Edward T., Rossanese, Olivia W., Waterson, Alex G., Chazin, Walter J., Fesik, Stephen W.

“…Replication protein A (RPA) is an essential single‐stranded DNA (ssDNA)‐binding protein that initiates the DNA damage response pathway through protein–protein…”
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Identification and Optimization of Anthranilic Acid Based Inhibitors of Replication ProteinA by Patrone, James D, Pelz, Nicholas F, Bates, Brittney S, Souza-Fagundes, Elaine M, Vangamudi, Bhavatarini, Camper, Demarco V, Kuznetsov, Alexey G, Browning, Carrie F, Feldkamp, Michael D, Frank, Andreas O, Gilston, Benjamin A, Olejniczak, Edward T, Rossanese, Olivia W, Waterson, Alex G, Chazin, Walter J, Fesik, Stephen W

“…Replication proteinA (RPA) is an essential single-stranded DNA (ssDNA)-binding protein that initiates the DNA damage response pathway through protein-protein…”
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Diphenylpyrazoles as Replication Protein A Inhibitors by Waterson, Alex G, Kennedy, J. Phillip, Patrone, James D, Pelz, Nicholas F, Feldkamp, Michael D, Frank, Andreas O, Vangamudi, Bhavatarini, Souza-Fagundes, Elaine M, Rossanese, Olivia W, Chazin, Walter J, Fesik, Stephen W

“…Replication Protein A is the primary eukaryotic ssDNA binding protein that has a central role in initiating the cellular response to DNA damage. RPA recruits…”
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Discovery of Protein–Protein Interaction Inhibitors of Replication Protein A by Patrone, James D, Kennedy, J. Phillip, Frank, Andreas O, Feldkamp, Michael D, Vangamudi, Bhavatarini, Pelz, Nicholas F, Rossanese, Olivia W, Waterson, Alex G, Chazin, Walter J, Fesik, Stephen W

“…Replication protein A (RPA) is a ssDNA binding protein that is essential for DNA replication and repair. The initiation of the DNA damage response by RPA is…”
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Abstract 3695: Discovery of probes to evaluate the disruption of the protein-protein interactions mediated by RPA70N by Waterson, Alex G., Kennedy, Phillip, Patrone, James D., Pelz, Nicholas F., Frank, Andreas O., Vangamudi, Bhavatarini, Camper, DeMarco V., Souza-Fagundes, Elaine M., Feldkamp, Michael D., Olejniczak, Edward T., Rossanese, Olivia W., Chazin, Walter J., Fesik, Stephen W.

“…Replication Protein A (RPA) is a major regulator of checkpoint activation and enhanced DNA repair in cancer cells. In response to genotoxic stress, the RPA…”
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Abstract 2473: Fragment-based discovery of inhibitors of replication protein A protein-protein interactions by Waterson, Alex G., Patrone, James D., Kennedy, J. Phillip, Pelz, Nicholas F., Frank, Andreas O., Vandgamudi, Bhavatarini, Feldkamp, Michael D., Souza-Fagundes, Elaine M., Rossanese, Olivia W., Chazin, Walter J., Fesik, Stephen W.

“…Replication Protein A (RPA) is a heterotrimeric protein that binds to and protects ssDNA and plays an integral role in initiating the cellular response to DNA…”
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Diphenylpyrazoles as Replication Protein A Inhibitors by Waterson, Alex G., Kennedy, J. Phillip, Patrone, James D., Pelz, Nicholas F., Feldkamp, Michael D., Frank, Andreas O., Vangamudi, Bhavatarini, Souza-Fagundes, Elaine M., Rossanese, Olivia W., Chazin, Walter J., Fesik, Stephen W.

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