Search Results - "Peluso, John"
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Cyclic Regulation of Sensory Perception by a Female Hormone Alters Behavior
Published in Cell (04-06-2015)“…Females may display dramatically different behavior depending on their state of ovulation. This is thought to occur through sex-specific hormones acting on…”
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Progestin and AdipoQ Receptor 7, Progesterone Membrane Receptor Component 1 (PGRMC1), and PGRMC2 and Their Role in Regulating Progesterone's Ability to Suppress Human Granulosa/Luteal Cells from Entering into the Cell Cycle
Published in Biology of reproduction (01-09-2015)“…The present studies were designed to determine the role of progesterone receptor membrane component 1 (PGRMC1), PGRMC2, progestin and adipoQ receptor 7…”
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MicroRNA-21 as a regulator of human cumulus cell viability and its potential influence on the developmental potential of the oocyte
Published in Biology of reproduction (01-07-2020)“…MicroRNA-21 is expressed in bovine, murine, and human cumulus cells with its expression in murine and bovine cumulus cells correlated with oocyte developmental…”
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Multiplicity of Progesterone's Actions and Receptors in the Mammalian Ovary
Published in Biology of reproduction (01-07-2006)“…This minireview summarizes the role that progesterone (P4) plays in regulating granulosa and luteal cell function. These actions include the stimulation of P4…”
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Progesterone Signaling and Mammalian Ovarian Follicle Growth Mediated by Progesterone Receptor Membrane Component Family Members
Published in Cells (Basel, Switzerland) (13-05-2022)“…How progesterone influences ovarian follicle growth is a difficult question to answer because ovarian cells synthesize progesterone and express not only the…”
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AG 205, a progesterone receptor membrane component 1 antagonist, ablates progesterone's ability to block oxidative stress-induced apoptosis of human granulosa/luteal cells
Published in Biology of reproduction (01-04-2017)“…The present studies were designed to determine whether progesterone (P4)-progesterone receptor membrane component 1 (PGRMC1) signaling is able to attenuate the…”
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Progesterone signaling mediated through progesterone receptor membrane component-1 in ovarian cells with special emphasis on ovarian cancer
Published in Steroids (01-08-2011)“…► Progesterone (P4) enhances ovarian cell survival in vitro. ► P4 inhibits apoptosis reducing the effect of cisplatin on ovarian cancer cells. ► Progesterone…”
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Progesterone receptor membrane component 1 and its role in ovarian follicle growth
Published in Frontiers in neuroscience (01-01-2013)“…Progesterone (P4) is synthesized in the ovary and acts directly on granulosa cells of developing ovarian follicles to suppress their rate of mitosis and…”
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Progesterone Receptor Membrane Component (PGRMC)1 and PGRMC2 and Their Roles in Ovarian and Endometrial Cancer
Published in Cancers (26-11-2021)“…Cancers of the female reproductive tract are both lethal and highly prevalent. For example, the five-year survival rate of women diagnosed with ovarian cancer…”
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Non-canonical progesterone signaling in granulosa cell function
Published in Reproduction (Cambridge, England) (01-05-2014)“…It has been known for over 3 decades that progesterone (P4) suppresses follicle growth. It has been assumed that P4 acts directly on granulosa cells of…”
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Progesterone Receptor Membrane Component-1 (PGRMC1) Is the Mediator of Progesterone’s Antiapoptotic Action in Spontaneously Immortalized Granulosa Cells As Revealed by PGRMC1 Small Interfering Ribonucleic Acid Treatment and Functional Analysis of PGRMC1 Mutations
Published in Endocrinology (Philadelphia) (01-02-2008)“…Progesterone (P4) receptor membrane component-1 (PGRMC1) and its binding partner, plasminogen activator inhibitor 1 RNA binding protein (PAIRBP1) are thought…”
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Progesterone receptor membrane component-1 (PGRMC1) and PGRMC-2 interact to suppress entry into the cell cycle in spontaneously immortalized rat granulosa cells
Published in Biology of reproduction (01-11-2014)“…Progesterone receptor membrane component 1 (PGRMC1) and PGRMC2 are expressed in rat granulosa cells and spontaneously immortalized granulosa cells (SIGCs) but…”
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PGRMC2 is an intracellular haem chaperone critical for adipocyte function
Published in Nature (London) (01-12-2019)“…Haem is an essential prosthetic group of numerous proteins and a central signalling molecule in many physiologic processes 1 , 2 . The chemical reactivity of…”
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Necessity is the mother of invention and the evolutionary force driving the success of in vitro fertilization
Published in Biology of reproduction (01-02-2021)“…During the last few decades, millions of healthy children have been born with the aid of in vitro fertilization (IVF). This success belies the fact that IVF…”
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Progesterone receptor membrane component 1 and 2 regulate granulosa cell mitosis and survival through a NFΚB-dependent mechanism
Published in Biology of reproduction (01-06-2019)“…Abstract Progesterone receptor membrane component 1 (PGRMC1) interacts with PGRMC2, and disrupting this interaction in spontaneously immortalized granulosa…”
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Evidence for a genomic mechanism of action for progesterone receptor membrane component-1
Published in Steroids (01-08-2012)“…An image of an in situ proximity assay demonstrating that PGRMC1 and Sumo1 directly interact and are presumably covalently coupled, as revealed by the red…”
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Conditional Ablation of Progesterone Receptor Membrane Component 1 Results in Subfertility in the Female and Development of Endometrial Cysts
Published in Endocrinology (Philadelphia) (01-09-2016)“…Progesterone (P4) is essential for female fertility. The objective of this study was to evaluate the functional requirement of the nonclassical P4 receptor…”
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A novel role for progesterone and progesterone receptor membrane component 1 in regulating spindle microtubule stability during rat and human ovarian cell mitosis
Published in Biology of reproduction (01-04-2011)“…The present studies were designed to assess the roles of progesterone (P4) and Progesterone Receptor Membrane Component 1 (PGRMC1) in regulating mitosis of…”
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Progesterone Regulation of Progesterone Receptor Membrane Component 1 (PGRMC1) Sumoylation and Transcriptional Activity in Spontaneously Immortalized Granulosa Cells
Published in Endocrinology (Philadelphia) (01-08-2012)“…Progesterone (P4) receptor membrane component (PGRMC)1 is detected as a 22-kDa band as well as higher molecular mass bands (>50 kDa) in spontaneously…”
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Progesterone Activates a Progesterone Receptor Membrane Component 1-Dependent Mechanism That Promotes Human Granulosa/Luteal Cell Survival But Not Progesterone Secretion
Published in The journal of clinical endocrinology and metabolism (01-07-2009)“…Context: Progesterone (P4) promotes its own secretion and the survival of human granulosa/luteal (GL) cells. Objective: The objective of these studies was to…”
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