Search Results - "Peltonen, Leena"

Design Space and QbD Approach for Production of Drug Nanocrystals by Wet Media Milling Techniques by Peltonen, Leena

“…Drug nanocrystals are nanosized solid drug particles, the most important application of which is the improvement of solubility properties of poorly soluble…”
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3D Printing of Drug Nanocrystals for Film Formulations by Germini, Giorgia, Peltonen, Leena

“…The aim of the study was to prepare indomethacin nanocrystal-loaded, 3D-printed, fast-dissolving oral polymeric film formulations. Nanocrystals were produced…”
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Pharmaceutical nanocrystals by nanomilling: critical process parameters, particle fracturing and stabilization methods by Peltonen, Leena, Hirvonen, Jouni

“…Objectives  Wet milling is a common technique to produce drug nanocrystals. Stability of the nanocrystals is a critical question, and different kinds of…”
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Stabilizing Agents for Drug Nanocrystals: Effect on Bioavailability by Tuomela, Annika, Hirvonen, Jouni, Peltonen, Leena

“…Drug nanocrystals are a versatile option for drug delivery purposes, and while the number of poorly soluble drug materials is all the time increasing, more…”
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Understanding Critical Quality Attributes for Nanocrystals from Preparation to Delivery by Peltonen, Leena, Strachan, Clare

“…Poor solubility of active pharmaceutical ingredients (APIs) is a great challenge for the pharmaceutical industry and, hence, drug nanocrystals are widely…”
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Production of Itraconazole Nanocrystal-Based Polymeric Film Formulations for Immediate Drug Release by Karagianni, Anna, Peltonen, Leena

“…In order to improve the solubility properties of BCS class II drug itraconazole, fast dissolving oral polymeric film formulations based on itraconazole…”
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Olive oil and clove oil-based nanoemulsion for topical delivery of terbinafine hydrochloride: in vitro and ex vivo evaluation by Gul, Uzma, Khan, Muhammad Imran, Madni, Asadullah, Sohail, Muhammad Farhan, Rehman, Mubashar, Rasul, Akhtar, Peltonen, Leena

“…In this article, formulation studies for terbinafine hydrochloride nanoemulsions, prepared by high-energy ultrasonication technique, are described…”
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Nanosuspensions of poorly soluble drugs: Preparation and development by wet milling by Liu, Peng, Rong, Xinyu, Laru, Johanna, van Veen, Bert, Kiesvaara, Juha, Hirvonen, Jouni, Laaksonen, Timo, Peltonen, Leena

“…Nanosizing techniques are important tools for improving the bioavailability of water insoluble drugs. Here, a rapid wet milling method was employed to prepare…”
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Childhood adversities are associated with shorter telomere length at adult age both in individuals with an anxiety disorder and controls by Kananen, Laura, Surakka, Ida, Pirkola, Sami, Suvisaari, Jaana, Lönnqvist, Jouko, Peltonen, Leena, Ripatti, Samuli, Hovatta, Iiris

“…Accelerated leukocyte telomere shortening has been previously associated to self-perceived stress and psychiatric disorders, including schizophrenia and mood…”
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Drug release from nanoparticles embedded in four different nanofibrillar cellulose aerogels by Valo, Hanna, Arola, Suvi, Laaksonen, Päivi, Torkkeli, Mika, Peltonen, Leena, Linder, Markus B., Serimaa, Ritva, Kuga, Shigenori, Hirvonen, Jouni, Laaksonen, Timo

“…[Display omitted] Highly porous nanocellulose aerogels prepared by freeze-drying from various nanofibrillar cellulose (NFC) hydrogels are introduced as…”
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A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses by Ripatti, Samuli, Dr, Tikkanen, Emmi, MSc, Orho-Melander, Marju, Prof, Havulinna, Aki S, MSc, Silander, Kaisa, PhD, Sharma, Amitabh, PhD, Guiducci, Candace, BS, Perola, Markus, Prof, Jula, Antti, MD, Sinisalo, Juha, MD, Lokki, Marja-Liisa, PhD, Nieminen, Markku S, Prof, Melander, Olle, MD, Salomaa, Veikko, Prof, Peltonen, Leena, Prof, Kathiresan, Sekar, MD

“…Summary Background Comparison of patients with coronary heart disease and controls in genome-wide association studies has revealed several single nucleotide…”
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Indomethacin: New Polymorphs of an Old Drug by Surwase, Sachin A, Boetker, Johan P, Saville, Dorothy, Boyd, Ben J, Gordon, Keith C, Peltonen, Leena, Strachan, Clare J

“…This study reports the appearance and characterization of multiple new polymorphic forms of indomethacin. Considering the interest in amorphous suspensions for…”
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Isolated populations and complex disease gene identification by Kristiansson, Kati, Naukkarinen, Jussi, Peltonen, Leena

“…The utility of genetically isolated populations (population isolates) in the mapping and identification of genes is not only limited to the study of rare…”
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Genome-wide association analysis of metabolic traits in a birth cohort from a founder population by Jones, Chris G, Peltonen, Leena, Ripatti, Samuli, Sovio, Ulla, Gabriel, Stacey, Kaakinen, Marika, Varilo, Teppo, Pouta, Anneli, Freimer, Nelson B, Brodsky, Jae, Turunen, Hannu, Hartikainen, Anna-Liisa, Hoggart, Clive, Ruokonen, Aimo, Coin, Lachlan, Service, Susan K, Elliot, Paul, Collins, Andrew, McCarthy, Mark I, Daly, Mark J, Zaitlen, Noah A, Jakkula, Eveliina, Sabatti, Chiara, Järvelin, Marjo-Riitta, Laitinen, Jaana

“…Nelson Freimer and colleagues report the first genome-wide association study of a longitudinal birth cohort (the Northern Finland Birth Cohort 1966). The…”
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Electrospraying, spray drying and related techniques for production and formulation of drug nanoparticles by Peltonen, Leena, Valo, Hanna, Kolakovic, Ruzica, Laaksonen, Timo, Hirvonen, Jouni

“…Spray drying and electrospraying are two widely used liquid atomization-based techniques for production and formulation of drug nanoparticles. The importance…”
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A population-specific HTR2B stop codon predisposes to severe impulsivity by Goldman, David, Bevilacqua, Laura, Doly, Stéphane, Kaprio, Jaakko, Yuan, Qiaoping, Tikkanen, Roope, Paunio, Tiina, Zhou, Zhifeng, Wedenoja, Juho, Maroteaux, Luc, Diaz, Silvina, Belmer, Arnaud, Hodgkinson, Colin A, Dell'Osso, Liliana, Suvisaari, Jaana, Coccaro, Emil, Rose, Richard J, Peltonen, Leena, Virkkunen, Matti

“…Impulsivity, describing action without foresight, is an important feature of several psychiatric diseases, suicidality and violent behaviour. The complex…”
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Multifunctional Hydrophobin: Toward Functional Coatings for Drug Nanoparticles by Valo, Hanna K, Laaksonen, Päivi H, Peltonen, Leena J, Linder, Markus B, Hirvonen, Jouni T, Laaksonen, Timo J

“…Efficient delivery of nanosized drug formulations to the desired body sites is not always reached despite the rapid development of pharmaceutical…”
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Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels by Derbinski, Jens, Gäbler, Jana, Brors, Benedikt, Tierling, Sascha, Jonnakuty, Sunitha, Hergenhahn, Manfred, Peltonen, Leena, Walter, Jörn, Kyewski, Bruno

“…The role of central tolerance induction has recently been revised after the discovery of promiscuous expression of tissue-restricted self-antigens in the…”
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Metabonomic, transcriptomic, and genomic variation of a population cohort by Inouye, Michael, Kettunen, Johannes, Soininen, Pasi, Silander, Kaisa, Ripatti, Samuli, Kumpula, Linda S, Hämäläinen, Eija, Jousilahti, Pekka, Kangas, Antti J, Männistö, Satu, Savolainen, Markku J, Jula, Antti, Leiviskä, Jaana, Palotie, Aarno, Salomaa, Veikko, Perola, Markus, Ala-Korpela, Mika, Peltonen, Leena

“…Comprehensive characterization of human tissues promises novel insights into the biological architecture of human diseases and traits. We assessed metabonomic,…”
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Valorization of Native Soluble and Insoluble Oat Side Streams for Stable Suspensions and Emulsions by Valoppi, Fabio, Wang, Yu-Jie, Alt, Giulia, Peltonen, Leena J., Mikkonen, Kirsi S.

“…Among different cereals, oat is becoming more popular due to its unique composition and health benefits. The increase in oat production is associated with an…”
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