Search Results - "Peltonen, L."

Is it advantageous to use quality by design (QbD) to develop nanoparticle-based dosage forms for parenteral drug administration? by Camacho Vieira, C., Peltonen, L., Karttunen, A.P., Ribeiro, A.J.

“…[Display omitted] Parenteral administration is one of the most commonly used drug delivery routes for nanoparticle-based dosage forms, such as lipid-based and…”
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A new highly penetrant form of obesity due to deletions on chromosome 16p11.2 by Froguel, P, Beckmann, J. S, Walters, R. G, Jacquemont, S, Valsesia, A, de Smith, A. J, Martinet, D, Andersson, J, Falchi, M, Chen, F, Andrieux, J, Lobbens, S, Delobel, B, Stutzmann, F, El-Sayed Moustafa, J. S, Chèvre, J.-C, Lecoeur, C, Vatin, V, Bouquillon, S, Buxton, J. L, Boute, O, Holder-Espinasse, M, Cuisset, J.-M, Lemaitre, M.-P, Ambresin, A.-E, Brioschi, A, Gaillard, M, Giusti, V, Fellmann, F, Ferrarini, A, Hadjikhani, N, Campion, D, Guilmatre, A, Goldenberg, A, Calmels, N, Mandel, J.-L, Le Caignec, C, David, A, Isidor, B, Cordier, M.-P, Dupuis-Girod, S, Labalme, A, Sanlaville, D, Béri-Dexheimer, M, Jonveaux, P, Leheup, B, Õunap, K, Bochukova, E. G, Henning, E, Keogh, J, Ellis, R. J, MacDermot, K. D, van Haelst, M. M, Vincent-Delorme, C, Plessis, G, Touraine, R, Philippe, A, Malan, V, Mathieu-Dramard, M, Chiesa, J, Blaumeiser, B, Kooy, R. F, Caiazzo, R, Pigeyre, M, Balkau, B, Sladek, R, Bergmann, S, Mooser, V, Waterworth, D, Reymond, A, Vollenweider, P, Waeber, G, Kurg, A, Palta, P, Esko, T, Metspalu, A, Nelis, M, Elliott, P, Hartikainen, A.-L, McCarthy, M. I, Peltonen, L, Carlsson, L, Jacobson, P, Sjöström, L, Huang, N, Hurles, M. E, O'Rahilly, S, Farooqi, I. S, Männik, K, Jarvelin, M.-R, Pattou, F, Meyre, D, Walley, A. J, Coin, L. J. M, Blakemore, A. I. F

“…Obesity has become a major worldwide challenge to public health, owing to an interaction between the Western 'obesogenic' environment and a strong genetic…”
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Development of an instrument for the evaluation of advanced life support performance by Peltonen, L.‐M., Peltonen, V., Salanterä, S., Tommila, M.

“…Background Assessing advanced life support (ALS) competence requires validated instruments. Existing instruments include aspects of technical skills (TS),…”
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Cerebral blood flow regulation in women across menstrual phase: differential contribution of cyclooxygenase to basal, hypoxic, and hypercapnic vascular tone by Peltonen, Garrett L, Harrell, John W, Aleckson, Benjamin P, LaPlante, Kaylie M, Crain, Meghan K, Schrage, William G

“…In healthy young women, basal cerebral blood flow (CBF) and cerebrovascular reactivity may change across the menstrual cycle, but mechanisms remain untested…”
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Quality, quantity and harmony: the DataSHaPER approach to integrating data across bioclinical studies by Fortier, Isabel, Burton, Paul R, Robson, Paula J, Ferretti, Vincent, Little, Julian, L’Heureux, Francois, Deschênes, Mylène, Knoppers, Bartha M, Doiron, Dany, Keers, Joost C, Linksted, Pamela, Harris, Jennifer R, Lachance, Geneviève, Boileau, Catherine, Pedersen, Nancy L, Hamilton, Carol M, Hveem, Kristian, Borugian, Marilyn J, Gallagher, Richard P, McLaughlin, John, Parker, Louise, Potter, John D, Gallacher, John, Kaaks, Rudolf, Liu, Bette, Sprosen, Tim, Vilain, Anne, Atkinson, Susan A, Rengifo, Andrea, Morton, Robin, Metspalu, Andres, Wichmann, H Erich, Tremblay, Mark, Chisholm, Rex L, Garcia-Montero, Andrés, Hillege, Hans, Litton, Jan-Eric, Palmer, Lyle J, Perola, Markus, Wolffenbuttel, Bruce HR, Peltonen, Leena, Hudson, Thomas J

“…Background Vast sample sizes are often essential in the quest to disentangle the complex interplay of the genetic, lifestyle, environmental and social factors…”
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Meta-analysis of genome-wide association studies for personality by de Moor, M H M, Costa, P T, Terracciano, A, Krueger, R F, de Geus, E J C, Toshiko, T, Penninx, B W J H, Esko, T, Madden, P A F, Derringer, J, Amin, N, Willemsen, G, Hottenga, J-J, Distel, M A, Uda, M, Sanna, S, Spinhoven, P, Hartman, C A, Sullivan, P, Realo, A, Allik, J, Heath, A C, Pergadia, M L, Agrawal, A, Lin, P, Grucza, R, Nutile, T, Ciullo, M, Rujescu, D, Giegling, I, Konte, B, Widen, E, Cousminer, D L, Eriksson, J G, Palotie, A, Peltonen, L, Luciano, M, Tenesa, A, Davies, G, Lopez, L M, Hansell, N K, Medland, S E, Ferrucci, L, Schlessinger, D, Montgomery, G W, Wright, M J, Aulchenko, Y S, Janssens, A C J W, Oostra, B A, Metspalu, A, Abecasis, G R, Deary, I J, Räikkönen, K, Bierut, L J, Martin, N G, van Duijn, C M, Boomsma, D I

“…Personality can be thought of as a set of characteristics that influence people's thoughts, feelings and behavior across a variety of settings. Variation in…”
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Better understanding of dissolution behaviour of amorphous drugs by in situ solid-state analysis using Raman spectroscopy by Savolainen, M., Kogermann, K., Heinz, A., Aaltonen, J., Peltonen, L., Strachan, C., Yliruusi, J.

“…Amorphous drugs have a higher kinetic solubility and dissolution rate than their crystalline counterparts. However, this advantage is lost if the amorphous…”
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Polymer incorporation method affects the physical stability of amorphous indomethacin in aqueous suspension by Surwase, S.A., Itkonen, L., Aaltonen, J., Saville, D., Rades, T., Peltonen, L., Strachan, C.J.

“…[Display omitted] This study reports the potential of different polymers and polymer incorporation methods to inhibit crystallisation and maintain…”
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Genomics and medicine. Dissecting human disease in the postgenomic era by Peltonen, L, McKusick, V A

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Copy number variations of chromosome 16p13.1 region associated with schizophrenia by Ingason, A, Rujescu, D, Cichon, S, Sigurdsson, E, Sigmundsson, T, Pietiläinen, O P H, Buizer-Voskamp, J E, Strengman, E, Francks, C, Muglia, P, Gylfason, A, Gustafsson, O, Olason, P I, Steinberg, S, Hansen, T, Jakobsen, K D, Rasmussen, H B, Giegling, I, Möller, H-J, Hartmann, A, Crombie, C, Fraser, G, Walker, N, Lonnqvist, J, Suvisaari, J, Tuulio-Henriksson, A, Bramon, E, Kiemeney, L A, Franke, B, Murray, R, Vassos, E, Toulopoulou, T, Mühleisen, T W, Tosato, S, Ruggeri, M, Djurovic, S, Andreassen, O A, Zhang, Z, Werge, T, Ophoff, R A, Rietschel, M, Nöthen, M M, Petursson, H, Stefansson, H, Peltonen, L, Collier, D, Stefansson, K, Clair, D M St

“…Deletions and reciprocal duplications of the chromosome 16p13.1 region have recently been reported in several cases of autism and mental retardation (MR). As…”
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DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder by Hennah, W, Thomson, P, McQuillin, A, Bass, N, Loukola, A, Anjorin, A, Blackwood, D, Curtis, D, Deary, I J, Harris, S E, Isometsä, E T, Lawrence, J, Lönnqvist, J, Muir, W, Palotie, A, Partonen, T, Paunio, T, Pylkkö, E, Robinson, M, Soronen, P, Suominen, K, Suvisaari, J, Thirumalai, S, Clair, D St, Gurling, H, Peltonen, L, Porteous, D

“…Disrupted in schizophrenia 1 (DISC1) has been associated with risk of schizophrenia, schizoaffective disorder, bipolar disorder, major depression, autism and…”
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Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21 by Spencer, Chris C A, Plagnol, Vincent, Strange, Amy, Gardner, Michelle, Paisan-Ruiz, Coro, Band, Gavin, Barker, Roger A, Bellenguez, Celine, Bhatia, Kailash, Blackburn, Hannah, Blackwell, Jennie M, Bramon, Elvira, Brown, Martin A, Brown, Matthew A, Burn, David, Casas, Juan-Pablo, Chinnery, Patrick F, Clarke, Carl E, Corvin, Aiden, Craddock, Nicholas, Deloukas, Panos, Edkins, Sarah, Evans, Jonathan, Freeman, Colin, Gray, Emma, Hardy, John, Hudson, Gavin, Hunt, Sarah, Jankowski, Janusz, Langford, Cordelia, Lees, Andrew J, Markus, Hugh S, Mathew, Christopher G, McCarthy, Mark I, Morrison, Karen E, Palmer, Colin N A, Pearson, Justin P, Peltonen, Leena, Pirinen, Matti, Plomin, Robert, Potter, Simon, Rautanen, Anna, Sawcer, Stephen J, Su, Zhan, Trembath, Richard C, Viswanathan, Ananth C, Williams, Nigel W, Morris, Huw R, Donnelly, Peter, Wood, Nicholas W

“…We performed a genome-wide association study (GWAS) in 1705 Parkinson's disease (PD) UK patients and 5175 UK controls, the largest sample size so far for a PD…”
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Meta-analysis of 32 genome-wide linkage studies of schizophrenia by Ng, M Y M, Levinson, D F, Faraone, S V, Suarez, B K, DeLisi, L E, Arinami, T, Riley, B, Paunio, T, Pulver, A E, Irmansyah, Holmans, P A, Escamilla, M, Wildenauer, D B, Williams, N M, Laurent, C, Mowry, B J, Brzustowicz, L M, Maziade, M, Sklar, P, Garver, D L, Abecasis, G R, Lerer, B, Fallin, M D, Gurling, H M D, Gejman, P V, Lindholm, E, Moises, H W, Byerley, W, Wijsman, E M, Forabosco, P, Tsuang, M T, Hwu, H-G, Okazaki, Y, Kendler, K S, Wormley, B, Fanous, A, Walsh, D, O'Neill, F A, Peltonen, L, Nestadt, G, Lasseter, V K, Liang, K Y, Papadimitriou, G M, Dikeos, D G, Schwab, S G, Owen, M J, O'Donovan, M C, Norton, N, Hare, E, Raventos, H, Nicolini, H, Albus, M, Maier, W, Nimgaonkar, V L, Terenius, L, Mallet, J, Jay, M, Godard, S, Nertney, D, Alexander, M, Crowe, R R, Silverman, J M, Bassett, A S, Roy, M-A, Mérette, C, Pato, C N, Pato, M T, Roos, J Louw, Kohn, Y, Amann-Zalcenstein, D, Kalsi, G, McQuillin, A, Curtis, D, Brynjolfson, J, Sigmundsson, T, Petursson, H, Sanders, A R, Duan, J, Jazin, E, Myles-Worsley, M, Karayiorgou, M, Lewis, C M

“…A genome scan meta-a nalysis (GSMA) was carried out on 32 independent genome-wide linkage scan analyses that included 3255 pedigrees with 7413 genotyped cases…”
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Parkinsonism, premature menopause, and mitochondrial DNA polymerase γ mutations: clinical and molecular genetic study by Luoma, Petri, Melberg, Atle, Rinne, Juha O, Kaukonen, Jyrki A, Nupponen, Nina N, Chalmers, Richard M, Oldfors, Anders, Rautakorpi, Ilkka, Peltonen, Leena, Majamaa, Kari, Somer, Hannu, Suomalainen, Anu

“…Mutations in the gene encoding mitochondrial DNA polymerase γ ( POLG), the enzyme that synthesises mitochondrial DNA (mtDNA), have been associated with a…”
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Replication of 1q42 linkage in Finnish schizophrenia pedigrees by EKELUND, J, HENNAH, W, HIEKKALINNA, T, PARKER, A, MEYER, J, LÖNNQVIST, J, PELTONEN, L

“…Chromosome 1q has been implicated in the etiology of schizophrenia in several independent studies. However, the peak linkage findings have been dispersed over…”
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Regulators of human white adipose browning: evidence for sympathetic control and sexual dimorphic responses to sprint interval training by Scalzo, Rebecca L, Peltonen, Garrett L, Giordano, Gregory R, Binns, Scott E, Klochak, Anna L, Paris, Hunter L R, Schweder, Melani M, Szallar, Steve E, Wood, Lacey M, Larson, Dennis G, Luckasen, Gary J, Hickey, Matthew S, Bell, Christopher

“…The conversion of white adipose to the highly thermogenic beige adipose tissue has been proposed as a potential strategy to counter the unfavorable…”
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Expanding the range of ZNF804A variants conferring risk of psychosis by Steinberg, S, Mors, O, Børglum, A D, Gustafsson, O, Werge, T, Mortensen, P B, Andreassen, O A, Sigurdsson, E, Thorgeirsson, T E, Böttcher, Y, Olason, P, Ophoff, R A, Cichon, S, Gudjonsdottir, I H, Pietiläinen, O P H, Nyegaard, M, Tuulio-Henriksson, A, Ingason, A, Hansen, T, Athanasiu, L, Suvisaari, J, Lonnqvist, J, Paunio, T, Hartmann, A, Jürgens, G, Nordentoft, M, Hougaard, D, Norgaard-Pedersen, B, Breuer, R, Möller, H-J, Giegling, I, Glenthøj, B, Rasmussen, H B, Mattheisen, M, Bitter, I, Réthelyi, J M, Sigmundsson, T, Fossdal, R, Thorsteinsdottir, U, Ruggeri, M, Tosato, S, Strengman, E, Kiemeney, L A, Melle, I, Djurovic, S, Abramova, L, Kaleda, V, Walshe, M, Bramon, E, Vassos, E, Li, T, Fraser, G, Walker, N, Toulopoulou, T, Yoon, J, Freimer, N B, Cantor, R M, Murray, R, Kong, A, Golimbet, V, Jönsson, E G, Terenius, L, Agartz, I, Petursson, H, Nöthen, M M, Rietschel, M, Peltonen, L, Rujescu, D, Collier, D A, Stefansson, H, St Clair, D, Stefansson, K

“…A trio of genome-wide association studies recently reported sequence variants at three loci to be significantly associated with schizophrenia. No sequence…”
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Association of DISC1 with autism and Asperger syndrome by Kilpinen, H, Ylisaukko-oja, T, Hennah, W, Palo, O M, Varilo, T, Vanhala, R, Nieminen-von Wendt, T, von Wendt, L, Paunio, T, Peltonen, L

“…The DISC1 gene at 1q42 has generated considerable interest in various psychiatric diseases, since a balanced translocation interrupting the gene was found to…”
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LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development by Gong, Yaoqin, Slee, Roger B., Fukai, Naomi, Rawadi, Georges, Roman-Roman, Sergio, Reginato, Anthony M., Wang, Hongwei, Cundy, Tim, Glorieux, Francis H., Lev, Dorit, Zacharin, Margaret, Oexle, Konrad, Marcelino, Jose, Suwairi, Wafaa, Heeger, Shauna, Sabatakos, George, Apte, Suneel, Adkins, William N., Allgrove, Jeremy, Arslan-Kirchner, Mine, Batch, Jennifer A., Beighton, Peter, Black, Graeme C.M., Boles, Richard G., Boon, Laurence M., Borrone, Carla, Brunner, Han G., Carle, Georges F., Dallapiccola, Bruno, De Paepe, Anne, Floege, Barbara, Halfhide, Melissa Lees, Hall, Bryan, Hennekam, Raoul C., Hirose, Tatsuo, Jans, Ab, Jüppner, Harald, Kim, Chong Ae, Keppler-Noreuil, Kim, Kohlschuetter, Alfried, LaCombe, Didier, Lambert, Marie, Lemyre, Emmanuelle, Letteboer, Tom, Peltonen, Leena, Ramesar, Rajkumar S., Romanengo, Marta, Somer, Hannu, Steichen-Gersdorf, Elisabeth, Steinmann, Beat, Sullivan, Beth, Superti-Furga, Andrea, Swoboda, Walter, van den Boogaard, Marie-José, Van Hul, Wim, Vikkula, Miikka, Votruba, Marcela, Zabel, Bernhard, Garcia, Teresa, Baron, Roland, Olsen, Bjorn R., Warman, Matthew L.

“…In humans, low peak bone mass is a significant risk factor for osteoporosis. We report that LRP5, encoding the low-density lipoprotein receptor-related protein…”
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Brief report: validity of Finnish registry-based diagnoses of autism with the ADI-R by Lampi, KM, Sourander, A, Gissler, M, Niemelä, S, Rehnström, K, Pulkkinen, E, Peltonen, L, Von Wendt, L

“…Aims:  The aim of the study was to explore the validity of registry‐based diagnoses of autism in Finland using the Autism Diagnostic Interview – Revised…”
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