Search Results - "Peltier, Julien"

Quantitative proteomic analysis exploring progression of colorectal cancer: Modulation of the serpin family by Peltier, Julien, Roperch, Jean-Pierre, Audebert, Stéphane, Borg, Jean-Paul, Camoin, Luc

“…Colorectal cancer (CRC) remains a major cause of cancer related-death in developed countries. The mortality risk is correlated with the stage of CRC determined…”
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The type VI secretion system deploys antifungal effectors against microbial competitors by Trunk, Katharina, Peltier, Julien, Liu, Yi-Chia, Dill, Brian D., Walker, Louise, Gow, Neil A. R., Stark, Michael J. R., Quinn, Janet, Strahl, Henrik, Trost, Matthias, Coulthurst, Sarah J.

“…Interactions between bacterial and fungal cells shape many polymicrobial communities. Bacteria elaborate diverse strategies to interact and compete with other…”
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Spatiotemporal Changes of the Phagosomal Proteome in Dendritic Cells in Response to LPS Stimulation by Pauwels, Anne-Marie, Härtlova, Anetta, Peltier, Julien, Driege, Yasmine, Baudelet, Griet, Brodin, Priscille, Trost, Matthias, Beyaert, Rudi, Hoffmann, Eik

“…In this study, spatiotemporal changes of the phagosomal proteome in dendritic cells are investigated by label-free, quantitative mass spectrometry to…”
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Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity by Huguenin-Dezot, Nicolas, De Cesare, Virginia, Peltier, Julien, Knebel, Axel, Kristaryianto, Yosua Adi, Rogerson, Daniel T., Kulathu, Yogesh, Trost, Matthias, Chin, Jason W.

“…Ubiquitin is post-translationally modified by phosphorylation at several sites, but the consequences of these modifications are largely unknown. Here, we…”
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Killing with proficiency: Integrated post-translational regulation of an offensive Type VI secretion system by Ostrowski, Adam, Cianfanelli, Francesca R, Porter, Michael, Mariano, Giuseppina, Peltier, Julien, Wong, Jun Jie, Swedlow, Jason R, Trost, Matthias, Coulthurst, Sarah J

“…The Type VI secretion system (T6SS) is widely used by bacterial pathogens as an effective weapon against bacterial competitors and is also deployed against…”
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Enhanced hippocampal LTP but normal NMDA receptor and AMPA receptor function in a rat model of CDKL5 deficiency disorder by Simões de Oliveira, Laura, O'Leary, Heather E, Nawaz, Sarfaraz, Loureiro, Rita, Davenport, Elizabeth C, Baxter, Paul, Louros, Susana R, Dando, Owen, Perkins, Emma, Peltier, Julien, Trost, Matthias, Osterweil, Emily K, Hardingham, Giles E, Cousin, Michael A, Chattarji, Sumantra, Booker, Sam A, Benke, Tim A, Wyllie, David J A, Kind, Peter C

“…Mutations in the X-linked gene cyclin-dependent kinase-like 5 (CDKL5) cause a severe neurological disorder characterised by early-onset epileptic seizures,…”
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Activation peptide of the coagulation factor XIII (AP-F13A1) as a new biomarker for the screening of colorectal cancer by Peltier, Julien, Roperch, Jean-Pierre, Audebert, Stéphane, Borg, Jean-Paul, Camoin, Luc

“…Colorectal cancer (CRC) remains a major cause of cancer fatalities in developed countries. The risk of death is correlated to the stage of CRC during the…”
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Thermal proteome profiling of breast cancer cells reveals proteasomal activation by CDK4/6 inhibitor palbociclib by Miettinen, Teemu P, Peltier, Julien, Härtlova, Anetta, Gierliński, Marek, Jansen, Valerie M, Trost, Matthias, Björklund, Mikael

“…Palbociclib is a CDK4/6 inhibitor approved for metastatic estrogen receptor‐positive breast cancer. In addition to G1 cell cycle arrest, palbociclib treatment…”
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LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages by Härtlova, Anetta, Herbst, Susanne, Peltier, Julien, Rodgers, Angela, Bilkei‐Gorzo, Orsolya, Fearns, Antony, Dill, Brian D, Lee, Heyne, Flynn, Rowan, Cowley, Sally A, Davies, Paul, Lewis, Patrick A, Ganley, Ian G, Martinez, Jennifer, Alessi, Dario R, Reith, Alastair D, Trost, Matthias, Gutierrez, Maximiliano G

“…Mutations in the leucine‐rich repeat kinase 2 (LRRK2) are associated with Parkinson's disease, chronic inflammation and mycobacterial infections. Although…”
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Phosphoproteomic screening identifies physiological substrates of the CDKL5 kinase by Muñoz, Ivan M, Morgan, Michael E, Peltier, Julien, Weiland, Florian, Gregorczyk, Mateusz, Brown, Fiona CM, Macartney, Thomas, Toth, Rachel, Trost, Matthias, Rouse, John

“…Mutations in the gene encoding the protein kinase CDKL5 cause a debilitating neurodevelopmental disease termed CDKL5 disorder. The impact of these mutations on…”
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Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation by Kazlauskaite, Agne, Martínez-Torres, R Julio, Wilkie, Scott, Kumar, Atul, Peltier, Julien, Gonzalez, Alba, Johnson, Clare, Zhang, Jinwei, Hope, Anthony G, Peggie, Mark, Trost, Matthias, van Aalten, Daan MF, Alessi, Dario R, Prescott, Alan R, Knebel, Axel, Walden, Helen, Muqit, Miratul MK

“…Mutations in the mitochondrial protein kinase PINK1 are associated with autosomal recessive Parkinson disease (PD). We and other groups have reported that…”
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Assessing the Phagosome Proteome by Quantitative Mass Spectrometry by Peltier, Julien, Härtlova, Anetta, Trost, Matthias

“…Phagocytosis is the process that engulfs particles in vesicles called phagosomes that are trafficked through a series of maturation steps, culminating in the…”
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The E3 ubiquitin ligase RNF115 regulates phagosome maturation and host response to bacterial infection by Bilkei‐Gorzo, Orsolya, Heunis, Tiaan, Marín‐Rubio, José Luis, Cianfanelli, Francesca Romana, Raymond, Benjamin Bernard Armando, Inns, Joseph, Fabrikova, Daniela, Peltier, Julien, Oakley, Fiona, Schmid, Ralf, Härtlova, Anetta, Trost, Matthias

“…Phagocytosis is a key process in innate immunity and homeostasis. After particle uptake, newly formed phagosomes mature by acquisition of endolysosomal…”
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Mass spectrometry techniques for studying the ubiquitin system by Heap, Rachel E, Gant, Megan S, Lamoliatte, Frederic, Peltier, Julien, Trost, Matthias

“…Post-translational control of proteins through covalent attachment of ubiquitin plays important roles in all eukaryotic cell functions. The ubiquitin system in…”
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Thermal proteome profiling of breast cancer cells reveals proteasomal activation by CDK 4/6 inhibitor palbociclib by Miettinen, Teemu P, Peltier, Julien, Härtlova, Anetta, Gierliński, Marek, Jansen, Valerie M, Trost, Matthias, Björklund, Mikael

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TPL‐2 kinase induces phagosome acidification to promote macrophage killing of bacteria by Breyer, Felix, Härtlova, Anetta, Thurston, Teresa, Flynn, Helen R, Chakravarty, Probir, Janzen, Julia, Peltier, Julien, Heunis, Tiaan, Snijders, Ambrosius P, Trost, Matthias, Ley, Steven C

“…Tumour progression locus 2 (TPL‐2) kinase mediates Toll‐like receptor (TLR) activation of ERK1/2 and p38α MAP kinases in myeloid cells to modulate expression…”
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Proteomics characterisation of the L929 cell supernatant and its role in BMDM differentiation by Heap, Rachel E, Marín-Rubio, José Luis, Peltier, Julien, Heunis, Tiaan, Dannoura, Abeer, Moore, Adam, Trost, Matthias

“…BMDMs are a key model system to study macrophage biology in vitro. Commonly used methods to differentiate macrophages from BM are treatment with either…”
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Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44 by Malik, Nazma, Nirujogi, Raja S, Peltier, Julien, Macartney, Thomas, Wightman, Melanie, Prescott, Alan R, Gourlay, Robert, Trost, Matthias, Alessi, Dario R, Karapetsas, Athanasios

“…The serum- and glucocorticoid-regulated kinase (SGK) isoforms contribute resistance to cancer therapies targeting the PI3K pathway. SGKs are homologous to Akt…”
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An ERK5-KLF2 signalling module regulates early embryonic gene expression and telomere rejuvenation in stem cells by Brown, Helen A, Williams, Charles A C, Zhou, Houjiang, Rios-Szwed, Diana, Fernandez-Alonso, Rosalia, Mansoor, Saria, McMulkin, Liam, Toth, Rachel, Gourlay, Robert, Peltier, Julien, Dieguez-Martinez, Nora, Trost, Matthias, Lizcano, Jose M, Stavridis, Marios P, Findlay, Greg M

“…The ERK5 MAP kinase signalling pathway drives transcription of naïve pluripotency genes in mouse Embryonic Stem Cells (mESCs). However, how ERK5 impacts on…”
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Separation techniques for intact antibody analysis by mass spectrometry by Schneck, Nicole A., Khatri, Kshitij, Maust, Matthew D., Jennings, Mark E., Peltier, Julien, Kellie, John F.

“…The possibilities to directly couple different separation methods with mass spectrometry (MS) for the analysis of intact proteins has attracted significant…”
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