Search Results - "Peloso, M."

Primordial Black Hole Dark Matter: LISA Serendipity by Bartolo, N, De Luca, V, Franciolini, G, Lewis, A, Peloso, M, Riotto, A

“…There has recently been renewed interest in the possibility that the dark matter in the Universe consists of primordial black holes (PBHs). Current…”
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Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19 by Huffman, Jennifer E., Butler-Laporte, Guillaume, Khan, Atlas, Pairo-Castineira, Erola, Drivas, Theodore G., Peloso, Gina M., Nakanishi, Tomoko, Ganna, Andrea, Verma, Anurag, Baillie, J. Kenneth, Kiryluk, Krzysztof, Richards, J. Brent, Zeberg, Hugo

“…The OAS1/2/3 cluster has been identified as a risk locus for severe COVID-19 among individuals of European ancestry, with a protective haplotype of…”
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Measurement of parity violation in the early universe using gravitational-wave detectors by Crowder, S.G., Namba, R., Mandic, V., Mukohyama, S., Peloso, M.

“…A stochastic gravitational-wave background (SGWB) is expected to arise from the superposition of many independent and unresolved gravitational-wave signals, of…”
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Toeplitz and Cesàro-type operators on homogeneous Siegel domains by Calzi, M., Peloso, M. M.

“…In this paper we study Toeplitz and Cesàro-type operators on holomorphic function spaces on a homogeneous Siegel domain of Type II. We prove several necessary…”
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Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents by Khetarpal, Sumeet A., Schjoldager, Katrine T., Christoffersen, Christina, Raghavan, Avanthi, Edmondson, Andrew C., Reutter, Heiko M., Ahmed, Bouhouche, Ouazzani, Reda, Peloso, Gina M., Vitali, Cecilia, Zhao, Wei, Somasundara, Amritha Varshini Hanasoge, Millar, John S., Park, YoSon, Fernando, Gayani, Livanov, Valentin, Choi, Seungbum, Noé, Eric, Patel, Pritesh, Ho, Siew Peng, Kirchgessner, Todd G., Wandall, Hans H., Hansen, Lars, Bennett, Eric P., Vakhrushev, Sergey Y., Saleheen, Danish, Kathiresan, Sekar, Brown, Christopher D., Abou Jamra, Rami, LeGuern, Eric, Clausen, Henrik, Rader, Daniel J.

“…Human genetics studies have implicated GALNT2, encoding GalNAc-T2, as a regulator of high-density lipoprotein cholesterol (HDL-C) metabolism, but…”
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Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia by Khera, Amit V., MD, Won, Hong-Hee, PhD, Peloso, Gina M., PhD, Lawson, Kim S., MS, Bartz, Traci M., MS, Deng, Xuan, MSc, van Leeuwen, Elisabeth M, Natarajan, Pradeep, MD, MMSc, Emdin, Connor A., HBSc, Bick, Alexander G., PhD, Morrison, Alanna C., PhD, Brody, Jennifer A., BA, Gupta, Namrata, PhD, Nomura, Akihiro, MD, Kessler, Thorsten, MD, Duga, Stefano, PhD, Bis, Joshua C., PhD, van Duijn, Cornelia M., PhD, Cupples, L. Adrienne, PhD, Psaty, Bruce, MD, PhD, Rader, Daniel J., MD, Danesh, John, DPhil, Schunkert, Heribert, MD, McPherson, Ruth, MD, Farrall, Martin, MD, Watkins, Hugh, MD, PhD, Lander, Eric, PhD, Wilson, James G., MD, Correa, Adolfo, MD, PhD, Boerwinkle, Eric, PhD, Merlini, Piera Angelica, MD, Ardissino, Diego, MD, Saleheen, Danish, MBBS, PhD, Gabriel, Stacey, PhD, Kathiresan, Sekar, MD

“…Abstract Background Approximately 7% of American adults have severe hypercholesterolemia (untreated low-density lipoprotein [LDL] cholesterol ≥190 mg/dl),…”
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Recurring exon deletions in the HP (haptoglobin) gene contribute to lower blood cholesterol levels by Boettger, Linda M, Salem, Rany M, Handsaker, Robert E, Peloso, Gina M, Kathiresan, Sekar, Hirschhorn, Joel N, McCarroll, Steven A

“…Steven McCarroll and colleagues present a detailed study of copy number variation of exons within the human HP (haptoglobin) gene. They show that HP exons…”
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Izokibep: Preclinical development and first-in-human study of a novel IL-17A neutralizing Affibody molecule in patients with plaque psoriasis by Klint, Susanne, Feldwisch, Joachim, Gudmundsdotter, Lindvi, Dillner Bergstedt, Karin, Gunneriusson, Elin, Höidén Guthenberg, Ingmarie, Wennborg, Anders, Nyborg, Andrew C, Kamboj, Amol P, Peloso, Paul M, Bejker, David, Frejd, Fredrik Y

“…Psoriasis, an immune-mediated inflammatory disease, affects nearly 125 million people globally. The interleukin (IL)-17A homodimer is a key driver of psoriasis…”
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Genome-wide discovery and integrative genomic characterization of insulin resistance loci using serum triglycerides to HDL-cholesterol ratio as a proxy by DeForest, Natalie, Wang, Yuqi, Zhu, Zhiyi, Dron, Jacqueline S., Koesterer, Ryan, Natarajan, Pradeep, Flannick, Jason, Amariuta, Tiffany, Peloso, Gina M., Majithia, Amit R.

“…Insulin resistance causes multiple epidemic metabolic diseases, including type 2 diabetes, cardiovascular disease, and fatty liver, but is not routinely…”
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A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels by Khetarpal, Sumeet A, Zeng, Xuemei, Millar, John S, Vitali, Cecilia, Somasundara, Amritha Varshini Hanasoge, Zanoni, Paolo, Landro, James A, Barucci, Nicole, Zavadoski, William J, Sun, Zhiyuan, de Haard, Hans, Toth, Ildikó V, Peloso, Gina M, Natarajan, Pradeep, Cuchel, Marina, Lund-Katz, Sissel, Phillips, Michael C, Tall, Alan R, Kathiresan, Sekar, DaSilva-Jardine, Paul, Yates, Nathan A, Rader, Daniel J

“…On the basis of new mechanistic studies of a mutant form of the apolipoprotein apoC-III that protects against coronary heart disease, Khetarpal et al. have…”
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Responder analysis for pain relief and numbers needed to treat in a meta-analysis of etoricoxib osteoarthritis trials: bridging a gap between clinical trials and clinical practice by Moore, R A, Moore, O A, Derry, S, Peloso, P M, Gammaitoni, A R, Wang, H

“…Population mean changes from clinical trials are difficult to apply to individuals in clinical practice. Responder analysis may be better, but needs validating…”
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Best practices and joint calling of the HumanExome BeadChip: the CHARGE Consortium by Grove, Megan L, Yu, Bing, Cochran, Barbara J, Haritunians, Talin, Bis, Joshua C, Taylor, Kent D, Hansen, Mark, Borecki, Ingrid B, Cupples, L Adrienne, Fornage, Myriam, Gudnason, Vilmundur, Harris, Tamara B, Kathiresan, Sekar, Kraaij, Robert, Launer, Lenore J, Levy, Daniel, Liu, Yongmei, Mosley, Thomas, Peloso, Gina M, Psaty, Bruce M, Rich, Stephen S, Rivadeneira, Fernando, Siscovick, David S, Smith, Albert V, Uitterlinden, Andre, van Duijn, Cornelia M, Wilson, James G, O'Donnell, Christopher J, Rotter, Jerome I, Boerwinkle, Eric

“…Genotyping arrays are a cost effective approach when typing previously-identified genetic polymorphisms in large numbers of samples. One limitation of…”
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Genetic modification of inflammation- and clonal hematopoiesis-associated cardiovascular risk by Yu, Zhi, Fidler, Trevor P, Ruan, Yunfeng, Vlasschaert, Caitlyn, Nakao, Tetsushi, Uddin, Md Mesbah, Mack, Taralynn, Niroula, Abhishek, Heimlich, J Brett, Zekavat, Seyedeh M, Gibson, Christopher J, Griffin, Gabriel K, Wang, Yuxuan, Peloso, Gina M, Heard-Costa, Nancy, Levy, Daniel, Vasan, Ramachandran S, Aguet, François, Ardlie, Kristin G, Taylor, Kent D, Rich, Stephen S, Rotter, Jerome I, Libby, Peter, Jaiswal, Siddhartha, Ebert, Benjamin L, Bick, Alexander G, Tall, Alan R, Natarajan, Pradeep

“…Clonal hematopoiesis of indeterminate potential (CHIP) is associated with an increased risk of cardiovascular diseases (CVDs), putatively via inflammasome…”
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Multiancestry Genome-Wide Association Study of Aortic Stenosis Identifies Multiple Novel Loci in the Million Veteran Program by Small, Aeron M., Peloso, Gina M., Linefsky, Jason, Aragam, Jayashri, Galloway, Ashley, Tanukonda, Vidisha, Wang, Lu-Chen, Yu, Zhi, Sunitha Selvaraj, Margaret, Farber-Eger, Eric H., Baker, Michael T., Setia-Verma, Shefali, Lee, Simon S.K., Preuss, Michael, Ritchie, Marylyn D., Damrauer, Scott M., Rader, Daniel J., Wells, Quinn S., Loos, Ruth, Lubitz, Steven A., Thanassoulis, George, Cho, Kelly, Wilson, Peter W.F., Natarajan, Pradeep, O’Donnell, Christopher J.

“…Calcific aortic stenosis (CAS) is the most common valvular heart disease in older adults and has no effective preventive therapies. Genome-wide association…”
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Genome-wide discovery for diabetes-dependent triglycerides-associated loci by Selvaraj, Margaret Sunitha, Paruchuri, Kaavya, Haidermota, Sara, Bernardo, Rachel, Rich, Stephen S, Peloso, Gina M, Natarajan, Pradeep

“…We aimed to discover loci associated with triglyceride (TG) levels in the context of type 2 diabetes (T2D). We conducted a genome-wide association study (GWAS)…”
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Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure by Rasooly, Danielle, Peloso, Gina M., Pereira, Alexandre C., Dashti, Hesam, Giambartolomei, Claudia, Wheeler, Eleanor, Aung, Nay, Ferolito, Brian R., Pietzner, Maik, Farber-Eger, Eric H., Wells, Quinn Stanton, Kosik, Nicole M., Gaziano, Liam, Posner, Daniel C., Bento, A. Patrícia, Hui, Qin, Liu, Chang, Aragam, Krishna, Wang, Zeyuan, Charest, Brian, Huffman, Jennifer E., Wilson, Peter W. F., Phillips, Lawrence S., Whittaker, John, Munroe, Patricia B., Petersen, Steffen E., Cho, Kelly, Leach, Andrew R., Magariños, María Paula, Gaziano, John Michael, Langenberg, Claudia, Sun, Yan V., Joseph, Jacob, Casas, Juan P.

“…We conduct a large-scale meta-analysis of heart failure genome-wide association studies (GWAS) consisting of over 90,000 heart failure cases and more than 1…”
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The burden and determinants of neck pain in workers: results of the Bone and Joint Decade 2000-2010 Task Force on Neck Pain and Its Associated Disorders by Côté, Pierre, van der Velde, Gabrielle, Cassidy, J David, Carroll, Linda J, Hogg-Johnson, Sheilah, Holm, Lena W, Carragee, Eugene J, Haldeman, Scott, Nordin, Margareta, Hurwitz, Eric L, Guzman, Jaime, Peloso, Paul M

“…Systematic review and best evidence synthesis. To describe the prevalence and incidence of neck pain and disability in workers; to identify risk factors for…”
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Structured mating: Patterns and implications by Sebro, Ronnie, Peloso, Gina M, Dupuis, Josée, Risch, Neil J

“…Genetic similarity of spouses can reflect factors influencing mate choice, such as physical/behavioral characteristics, and patterns of social endogamy. Spouse…”
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Beverage Consumption and Longitudinal Changes in Lipoprotein Concentrations and Incident Dyslipidemia in US Adults: The Framingham Heart Study by Haslam, Danielle E, Peloso, Gina M, Herman, Mark A, Dupuis, Josée, Lichtenstein, Alice H, Smith, Caren E, McKeown, Nicola M

“…Background Limited data are available on the prospective relationship between beverage consumption and plasma lipid and lipoprotein concentrations. Two major…”
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Lipid levels and risk of acute pancreatitis using bidirectional Mendelian randomization by Wang, Biqi, Dron, Jacqueline S., Wang, Yuxuan, Choi, Seung Hoan, Huffman, Jennifer E., Cho, Kelly, Wilson, Peter W. F., Natarajan, Pradeep, Peloso, Gina M.

“…Previous studies found lipid levels, especially triglycerides (TG), are associated with acute pancreatitis, but their causalities and bi-directions were not…”
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