Search Results - "Pellowe, Grant A."

Cell-free expression tools to study co-translational folding of alpha helical membrane transporters by Harris, Nicola J., Pellowe, Grant A., Booth, Paula J.

“…Most helical membrane proteins fold co-translationally during unidirectional polypeptide elongation by the ribosome. Studies thus far, however, have largely…”
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Hydrogen-deuterium exchange mass spectrometry captures distinct dynamics upon substrate and inhibitor binding to a transporter by Jia, Ruyu, Martens, Chloe, Shekhar, Mrinal, Pant, Shashank, Pellowe, Grant A., Lau, Andy M., Findlay, Heather E., Harris, Nicola J., Tajkhorshid, Emad, Booth, Paula J., Politis, Argyris

“…Proton-coupled transporters use transmembrane proton gradients to power active transport of nutrients inside the cell. High-resolution structures often fail to…”
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Methods to study folding of alpha-helical membrane proteins in lipids by Harris, Nicola J, Pellowe, Grant A, Blackholly, Laura R, Gulaidi-Breen, Samuel, Findlay, Heather E, Booth, Paula J

“…How alpha-helical membrane proteins fold correctly in the highly hydrophobic membrane interior is not well understood. Their folding is known to be highly…”
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Structural insight into co-translational membrane protein folding by Pellowe, Grant A., Booth, Paula J.

“…Membrane protein folding studies lag behind those of water-soluble proteins due to immense difficulties of experimental study, resulting from the need to…”
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Mechanism of chaperone coordination during cotranslational protein folding in bacteria by Roeselová, Alžběta, Maslen, Sarah L, Shivakumaraswamy, Santosh, Pellowe, Grant A, Howell, Steven, Joshi, Dhira, Redmond, Joanna, Kjær, Svend, Skehel, J Mark, Balchin, David

“…Protein folding is assisted by molecular chaperones that bind nascent polypeptides during mRNA translation. Several structurally distinct classes of chaperones…”
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How lipids affect the energetics of co-translational alpha helical membrane protein folding by Brady, Ryan, Harris, Nicola J, Pellowe, Grant A, Gulaidi Breen, Samuel, Booth, Paula J

“…Membrane proteins need to fold with precision in order to function correctly, with misfolding potentially leading to disease. The proteins reside within a…”
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Capturing Membrane Protein Ribosome Nascent Chain Complexes in a Native-like Environment for Co-translational Studies by Pellowe, Grant A, Findlay, Heather E, Lee, Karen, Gemeinhardt, Tim M, Blackholly, Laura R, Reading, Eamonn, Booth, Paula J

“…Co-translational folding studies of membrane proteins lag behind cytosolic protein investigations largely due to the technical difficulty in maintaining…”
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