Search Results - "Pelloquin, Laetitia"

The BH3-only Bnip3 binds to the dynamin Opa1 to promote mitochondrial fragmentation and apoptosis by distinct mechanisms by Landes, Thomas, Emorine, Laurent J, Courilleau, Delphine, Rojo, Manuel, Belenguer, Pascale, Arnauné-Pelloquin, Laetitia

“…Opa1 modulates mitochondrial fusion, cristae structure and apoptosis. The relationships between these functions and autosomal dominant optic atrophy, caused by…”
Get full text

HIV‐1 Vpr inhibits autophagy during the early steps of infection of CD4 T cells by Alfaisal, Jamal, Machado, Alice, Galais, Mathilde, Robert‐Hebmann, Véronique, Arnauné‐Pelloquin, Laetitia, Espert, Lucile, Biard‐Piechaczyk, Martine

“…Background information Autophagy is induced during HIV‐1 entry into CD4 T cells by the fusion of the membranes triggered by the gp41 envelope glycoprotein…”
Get full text

OPA1 haploinsufficiency induces a BNIP3‐dependent decrease in mitophagy in neurons: relevance to Dominant Optic Atrophy by Moulis, Manon F, Millet, Aurélie M, Daloyau, Marlène, Miquel, Marie‐Christine, Ronsin, Brice, Wissinger, Bernd, Arnauné‐Pelloquin, Laetitia, Belenguer, Pascale

“…Dominant optic atrophy (DOA) is because of mutations in the mitochondrial protein OPA1. The disease principally affects retinal ganglion cells, whose axons…”
Get full text

The Metabolomic Signature of Opa1 Deficiency in Rat Primary Cortical Neurons Shows Aspartate/Glutamate Depletion and Phospholipids Remodeling by Chao de la Barca, Juan Manuel, Arrázola, Macarena S., Bocca, Cinzia, Arnauné-Pelloquin, Laetitia, Iuliano, Olga, Tcherkez, Guillaume, Lenaers, Guy, Simard, Gilles, Belenguer, Pascale, Reynier, Pascal

“…Pathogenic variants of OPA1 , which encodes a dynamin GTPase involved in mitochondrial fusion, are responsible for a spectrum of neurological disorders sharing…”
Get full text

Mitochondria in Developmental and Adult Neurogenesis by Arrázola, Macarena S., Andraini, Trinovita, Szelechowski, Marion, Mouledous, Lionel, Arnauné-Pelloquin, Laetitia, Davezac, Noélie, Belenguer, Pascale, Rampon, Claire, Miquel, Marie-Christine

“…Generation of new neurons is a tightly regulated process that involves several intrinsic and extrinsic factors. Among them, a metabolic switch from glycolysis…”
Get full text

Effects of OPA1 mutations on mitochondrial morphology and apoptosis: Relevance to ADOA pathogenesis by Olichon, Aurélien, Landes, Thomas, Arnauné-Pelloquin, Laetitia, Emorine, Laurent J., Mils, Valérie, Guichet, Agnès, Delettre, Cécile, Hamel, Christian, Amati-Bonneau, Patrizia, Bonneau, Dominique, Reynier, Pascal, Lenaers, Guy, Belenguer, Pascale

“…To characterize the molecular links between type‐1 autosomal dominant optic atrophy (ADOA) and OPA1 dysfunctions, the effects of pathogenic alleles of this…”
Get full text

Loss of Msp1p in Schizosaccharomyces pombe induces a ROS‐dependent nuclear mutator phenotype that affects mitochondrial fission genes by Delerue, Thomas, Khosrobakhsh, Farnoosh, Daloyau, Marlène, Emorine, Laurent Jean, Dedieu, Adrien, Herbert, Christopher J., Bonnefoy, Nathalie, Arnauné‐Pelloquin, Laetitia, Belenguer, Pascale

“…Mitochondria continually fuse and divide to dynamically adapt to changes in metabolism and stress. Mitochondrial dynamics are also required for mitochondrial…”
Get full text

A yeast-based screening assay identifies repurposed drugs that suppress mitochondrial fusion and mtDNA maintenance defects by Delerue, Thomas, Tribouillard-Tanvier, Déborah, Daloyau, Marlène, Khosrobakhsh, Farnoosh, Emorine, Laurent Jean, Friocourt, Gaëlle, Belenguer, Pascale, Blondel, Marc, Arnauné-Pelloquin, Laetitia

“…Mitochondria continually move, fuse and divide, and these dynamics are essential for the proper function of the organelles. Indeed, the dynamic balance of…”
Get full text

Inner-membrane proteins PMI/TMEM11 regulate mitochondrial morphogenesis independently of the DRP1/MFN fission/fusion pathways by Rival, Thomas, Macchi, Marc, Arnauné-Pelloquin, Laetitia, Poidevin, Mickael, Maillet, Frédéric, Richard, Fabrice, Fatmi, Ahmed, Belenguer, Pascale, Royet, Julien

“…Mitochondria are highly dynamic organelles that can change in number and morphology during cell cycle, development or in response to extracellular stimuli…”
Get full text

Mitochondrial dynamics and disease, OPA1 by Olichon, Aurélien, Guillou, Emmanuelle, Delettre, Cécile, Landes, Thomas, Arnauné-Pelloquin, Laetitia, Emorine, Laurent J., Mils, Valérie, Daloyau, Marlène, Hamel, Christian, Amati-Bonneau, Patrizia, Bonneau, Dominique, Reynier, Pascal, Lenaers, Guy, Belenguer, Pascale

“…The mitochondria are dynamic organelles that constantly fuse and divide. An equilibrium between fusion and fission controls the morphology of the mitochondria,…”
Get full text

Mitochondrial OPA1 Deficiency Is Associated to Reversible Defects in Spatial Memory Related to Adult Neurogenesis in Mice by Andraini, Trinovita, Moulédous, Lionel, Petsophonsakul, Petnoi, Florian, Cédrick, Gauzin, Sébastien, Botella-Daloyau, Marlène, Arrázola, Macarena, Nikolla, Kamela, Philip, Adam, Leydier, Alice, Marque, Manon, Arnauné-Pelloquin, Laetitia, Belenguer, Pascale, Rampon, Claire, Miquel, Marie-Christine

“…Mitochondria are integrative hubs central to cellular adaptive pathways. Such pathways are critical in highly differentiated postmitotic neurons, the…”
Get full text

Nuclear gene OPA1 , encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy by Lorenzo, Corinne, Hamel, Christian P, Griffoin, Jean-Michel, Turc-Carel, Claude, Delettre, Cécile, Lenaers, Guy, Kaplan, Josseline, Lasquellec, Laetitia, Belenguer, Pascale, Astarie-Dequeker, Catherine, Gigarel, Nadine, Grosgeorge, Josiane, Arnaud, Bernard, Pelloquin, Laetitia, Ducommun, Bernard, Perret, Eric

“…Optic atrophy type 1 (OPA1, MIM 165500) is a dominantly inherited optic neuropathy occurring in 1 in 50,000 individuals that features progressive loss in…”
Get full text

The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space by Olichon, Aurélien, Emorine, Laurent J, Descoins, Eric, Pelloquin, Laetitia, Brichese, Laetitia, Gas, Nicole, Guillou, Emmanuelle, Delettre, Cécile, Valette, Annie, Hamel, Christian P, Ducommun, Bernard, Lenaers, Guy, Belenguer, Pascale

“…Mutations in the OPA1 gene are associated with autosomal dominant optic atrophy. OPA1 encodes a dynamin-related protein orthologous to Msp1 of…”
Get full text

OPA1 (dys)functions by Landes, Thomas, Leroy, Ingrid, Bertholet, Ambre, Diot, Alan, Khosrobakhsh, Farnoosh, Daloyau, Marlène, Davezac, Noélie, Miquel, Marie-Christine, Courilleau, Delphine, Guillou, Emmanuelle, Olichon, Aurélien, Lenaers, Guy, Arnauné-Pelloquin, Laetitia, Emorine, Laurent J., Belenguer, Pascale

“…Mitochondrial morphology varies according to cell type and cellular context from an interconnected filamentous network to isolated dots. This morphological…”
Get full text

Transmembrane segments of the dynamin Msp1p uncouple its functions in the control of mitochondrial morphology and genome maintenance by Diot, Alan, Guillou, Emmanuelle, Daloyau, Marlène, Arnauné-Pelloquin, Laetitia, Emorine, Laurent J, Belenguer, Pascale

“…Mitochondrial morphology depends on the equilibrium between antagonistic fission and fusion forces acting on mitochondrial membranes. Inactivation of fusion…”
Get full text

Processing of the dynamin Msp1p in S. pombe reveals an evolutionary switch between its orthologs Mgm1p in S. cerevisiae and OPA1 in mammals by Leroy, Ingrid, Khosrobakhsh, Farnoosh, Diot, Alan, Daloyau, Marlène, Arnauné-Pelloquin, Laetitia, Cavelier, Cindy, Emorine, Laurent J., Belenguer, Pascale

“…Mitochondrial fusion depends on the evolutionary conserved dynamin, OPA1/Mgm1p/Msp1p, whose activity is controlled by proteolytic processing. Since processing…”
Get full text

Mitochondrial morphology and dynamics: actors, mechanisms and functions by Sauvanet, Cécile, Arnauné-Pelloquin, Laetitia, David, Claudine, Belenguer, Pascale, Rojo, Manuel

“…Mitochondria are dynamic organelles that continuously move, fuse and divide. Their overall morphology, ranging from a filamentous network to a collection of…”
Get more information

Inner‐membrane proteins PMI/TMEM11 regulate mitochondrial morphogenesis independently of the DRP1/MFN fission/fusion pathways by Rival, Thomas, Macchi, Marc, Arnauné‐pelloquin, Laetitia, Poidevin, Mickael, Maillet, Frédéric, Richard, Fabrice, Fatmi, Ahmed, Belenguer, Pascale, Royet, Julien

“…Mitochondria are highly dynamic organelles that can change in number and morphology during cell cycle, development or in response to extracellular stimuli…”
Get full text

Mitochondrial OPA1 Deficiency Is Associated to Reversible Defects in Spatial Memory Related to Adult Neurogenesis in Mice by Andraini, Trinovita, Moulédous, Lionel, Petsophonsakul, Petnoi, Florian, Cédrick, Gauzin, Sébastien, Botella-Daloyau, Marlène, Arrázola, Macarena, Nikolla, Kamela, Philip, Adam, Leydier, Alice, Marque, Manon, Arnauné-Pelloquin, Laetitia, Belenguer, Pascale, Rampon, Claire, Miquel, Marie-Christine

“…Abstract Mitochondria are integrative hubs central to cellular adaptive pathways. Such pathways are critical in highly differentiated postmitotic neurons, the…”
Get full text

Fission yeast mfr1 activates APC and coordinates meiotic nuclear division with sporulation by Blanco, M A, Pelloquin, L, Moreno, S

“…Meiosis is the developmental program by which sexually reproducing diploid organisms generate haploid gametes. In yeast, meiosis is followed by spore…”
Get full text