Search Results - "Pellis, N R"

Modeled microgravity-induced protein kinase C isoform expression in human lymphocytes by Sundaresan, A, Risin, D, Pellis, N. R

“…1 Division of Space Life Sciences, Universities Space Research Association, 2 Biological Systems Office, and 3 Biological Sciences and Applications Office,…”
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Suppressed PHA activation of T lymphocytes in simulated microgravity is restored by direct activation of protein kinase C by Cooper, D., Pellis, N. R., McIntire, L. V.

“…Utilizing clinostatic rotating wall vessel (RWV) bioreactors that simulate aspects of microgravity, we found phytohemagglutinin (PHA) responsiveness to be…”
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Altered cytokine expression in tissues of mice subjected to simulated microgravity by Felix, K, Wise, K, Manna, S, Yamauchi, K, Wilson, B L, Thomas, R L, Kulkarni, A, Pellis, N R, Ramesh, G T

“…Space flight is known to induce microgravity-associated immune dysfunction in humans, non-human primates and rodents. To understand the mechanism underlying…”
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Induction of Three-Dimensional Assembly of Human Liver Cells by Simulated Microgravity by Vladimir I. Khaoustov, Darlington, Gretchen J., Soriano, Humberto E., Bhuvaneswari Krishnan, Diana Risin, Pellis, Neal R., Yoffe, Boris

“…The establishment of long-term cultures of functional primary human liver cells (PHLC) is formidable. Developed at NASA, the Rotary Cell Culture System (RCCS)…”
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Nutrition beyond nutrition: plausibility of immunotrophic nutrition for space travel by KULKARNI, A.D., YAMAUCHI, K., HALES, N.W., RAMESH, V., RAMESH, G.T., SUNDARESAN, A., ANDRASSY, R.J., PELLIS, N.R.

“…Background and aims: Microgravity has adverse effects on the immune system. We examined the effects of supplemental dietary nucleotides on immune function in…”
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Modeled Microgravity Inhibits Apoptosis in Peripheral Blood Lymphocytes by Diana Risin, Pellis, Neal R.

“…Microgravity interferes with numerous lymphocyte functions (expression of cell surface molecules, locomotion, polyclonal and antigen-specific activation, and…”
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Multidimensional flow-cytometric analysis of dendritic cells in peripheral blood of normal donors and cancer patients by SAVARY, C. A, GRAZZIUTTI, M. L, PIERSON, D. L, PELLIS, N. R, REX, J. H, MELICHAR, B, PRZEPIORKA, D, FREEDMAN, R. S, COWART, R. E, COHEN, D. M, ANAISSIE, E. J, WOODSIDE, D. G, MCINTYRE, B. W

“…We studied the potential of multidimensional flow cytometry to evaluate the frequency and maturation/activation status of dendritic cells in minimally…”
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Tissue Engineering of Cartilage in Space by Freed, Lisa E., Langer, Robert, Martin, Ivan, Pellis, Neal R., Vunjak-Novakovic, Gordana

“…Tissue engineering of cartilage, i.e., the in vitro cultivation of cartilage cells on synthetic polymer scaffolds, was studied on the Mir Space Station and on…”
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SUPPRESSION OF ANTIGEN-SPECIFIC LYMPHOCYTE ACTIVATION IN MODELED MICROGRAVITY by COOPER, DAVID, PRIDE, MICHAEL W, BROWN, ERIC L, RISIN, DIANA, PELLIS, NEAL R

“…Various parameters of immune suppression are observed in lymphocytes from astronauts during and after a space flight. It is difficult to ascribe this…”
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Cultures of human liver cells in simulated microgravity environment by Yoffe, B., Darlington, G.J., Soriano, H.E., Krishnan, B., Risin, D., Pellis, N.R., Khaoustov, V.I.

“…We used microgravity-simulated bioreactors that create the unique environment of low shear force and high-mass transfer to establish long-term cultures of…”
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Changes in Gravity Inhibit Lymphocyte Locomotion through Type I Collagen by Pellis, Neal R., Thomas J. Goodwin, Diana Risin, McIntyre, Bradley W., Roland P. Pizzini, Cooper, David, Tacey L. Baker, Glenn F. Spaulding

“…Immunity relies on the circulation of lymphocytes through many different tissues including blood vessels, lymphatic channels, and lymphoid organs. The ability…”
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CHARACTERISTICS OF HUMAN DENDRITIC CELLS GENERATED IN A MICROGRAVITY ANALOG CULTURE SYSTEM by SAVARY, CHERYLYN A, GRAZZIUTTI, MONICA L, PRZEPIORKA, DONNA, TOMASOVIC, STEPHEN P, McINTYRE, BRADLEY W, WOODSIDE, DARREN G, PELLIS, NEAL R, PIERSON, DUANE L, REX, JOHN H

“…Generation of an effective immune response requires that antigens be processed and presented to T lymphocytes by antigen-presenting cells, the most efficient…”
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Locomotion of lymphocytes towards melanoma cells treated with tumor necrosis factor in a syngeneic in vitro model by Gutman, H, Laish-Farkash, A, Risin, D, Pellis, N R

“…Tumor necrosis factor (TNF) causes cell necrosis in vivo by damaging the endothelium of the neovasculature. However, its mechanism of action is not well…”
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Impairment of lymphocyte locomotion in the tumor microenvironment and the effect of systemic immunotherapy with liposome-encapsulated muramyl-tripeptide-phosphatidylethanolamine by RISIN, D, KLEINERMAN, E. S, UMEZU, Y, PIZZINI, R. P, BALCH, C. M, PELLIS, N. R

“…The ability of the lymphocytes to move through the interstitium is obligatory to the immune response. We previously showed that tumor-infiltrating lymphocytes…”
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Evidence that opiate addiction is in part an immune response. Destruction of the immune system by irradiation-altered opiate withdrawal by Dafny, N, Pellis, N R

“…Experiments were performed to determine whether physical dependence on opiates (CNS phenomena) can be altered by destruction of the immune system. Irradiation,…”
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The brain and the immune system: an intact immune system is essential for the manifestation of withdrawal in opiate addicted rats by Dougherty, P M, Pellis, N R, Dafny, N

“…Gamma irradiation (500 rad) is often used to suppress the immune system in mice, rats and man. Recently, it was shown that irradiation prior to chronic…”
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MICROARRAY ANALYSIS OF GENES DIFFERENTIALLY EXPRESSED IN HEPG2 CELLS CULTURED IN SIMULATED MICROGRAVITY: PRELIMINARY REPORT by KHAOUSTOV, VLADIMIR I, RISIN, DIANA, PELLIS, NEAL R, YOFFE, BORIS

“…Developed at NASA, the rotary cell culture system (RCCS) allows the creation of unique microgravity environment of low shear force, high-mass transfer, and…”
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Effects of Microgravity on the Embryonic Pancreas by Michael I. Rose, Dale C. Brown, Neil R. Pellis, Christopher A. Crisera, Kari L. Colen, Longaker, Michael T., Gittes, George K.

“…The mechanism by which the complex structure and function of the pancreas is created has become a more active field of research in recent years. Underlying…”
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Differential modification of morphine and methadone dependence by interferon alpha by Dougherty, P M, Pearl, J, Krajewski, K J, Pellis, N R, Dafny, N

“…Subcutaneous implantation of a pellet of methadone was presented as a novel method for the establishment of physical dependence upon this agent and it was…”
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Effects of concomitant and sinecomitant immunity on postsurgical metastasis in mice by NOMI, S, NAITO, K, KAHAN, B. D, PELLIS, N. R

“…The role of concomitant and sinecomitant antitumor resistance in the regulation of metastatic outgrowth was assessed using methylcholanthrene (MCA)-induced…”
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