Search Results - "Pellicelli, Martin"

Dephosphorylation of the transcriptional cofactor NACA by the PP1A phosphatase enhances cJUN transcriptional activity and osteoblast differentiation by Addison, William N., Pellicelli, Martin, St-Arnaud, René

“…The transcriptional cofactor nascent polypeptide-associated complex and co-regulator α (NACA) regulates osteoblast maturation and activity. NACA functions, at…”
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E2F1 and TFDP1 Regulate PITX1 Expression in Normal and Osteoarthritic Articular Chondrocytes by Pellicelli, Martin, Picard, Cynthia, Wang, DaShen, Lavigne, Patrick, Moreau, Alain

“…We previously reported a loss-of-PITX1 expression in patients suffering of knee/hip osteoarthritis (OA). Search for the mechanism underlying this event led us…”
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NACA and LRP6 Are Part of a Common Genetic Pathway Necessary for Full Anabolic Response to Intermittent PTH by St-Arnaud, René, Pellicelli, Martin, Ismail, Mahmoud, Arabian, Alice, Jafarov, Toghrul, Zhou, Chengji J

“…PTH induces phosphorylation of the transcriptional coregulator NACA on serine 99 through Gαs and PKA. This leads to nuclear translocation of NACA and…”
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PTHrP(1-34)-mediated repression of the PHEX gene in osteoblastic cells involves the transcriptional repressor E4BP4 by Pellicelli, Martin, Taheri, Maryam, St-Louis, Mathieu, Bériault, Véronique, Desgroseillers, Luc, Boileau, Guy, Moreau, Alain

“…PHosphate‐regulating gene with homology to Endopeptidase on the X chromosome (PHEX) has been identified as the gene mutated in X‐linked hypophosphatemia (XLH)…”
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Nfil3, a target of the NACA transcriptional coregulator, affects osteoblast and osteocyte gene expression differentially by Hariri, Hadla, Pellicelli, Martin, St-Arnaud, René

“…Intermittent administration of PTH(1–34) has a profound osteoanabolic effect on the skeleton. At the cellular level, osteoblasts and osteocytes are two crucial…”
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Lrp6 is a target of the PTH-activated αNAC transcriptional coregulator by Pellicelli, Martin, Hariri, Hadla, Miller, Julie A., St-Arnaud, René

“…In the nucleus of differentiated osteoblasts, the alpha chain of nascent polypeptide associated complex (αNAC) interacts with cJUN transcription factors to…”
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New PTH Signals Mediating Bone Anabolism by Hariri, Hadla, Pellicelli, Martin, St-Arnaud, René

“…Purpose of Review Because of its clinical relevance, extensive work has been performed to uncover the signaling pathways modulated by parathyroid hormone…”
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The PTH-Gαs-Protein Kinase A Cascade Controls αNAC Localization To Regulate Bone Mass by Pellicelli, Martin, Miller, Julie A., Arabian, Alice, Gauthier, Claude, Akhouayri, Omar, Wu, Joy Y., Kronenberg, Henry M., St-Arnaud, René

“…The binding of PTH to its receptor induces Gα s -dependent cyclic AMP (cAMP) accumulation to turn on effector kinases, including protein kinase A (PKA). The…”
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FIAT deletion increases bone mass but does not prevent high-fat-diet-induced metabolic complications by Hekmatnejad, Bahareh, Yu, Vionnie W.C, Addison, William, Mandic, Vice, Pellicelli, Martin, Arabian, Alice, St-Arnaud, René

“…FIAT (Factor Inhibiting ATF4-mediated Transcription) interacts with ATF4 to repress its transcriptional activity. We performed a phenotypic analysis of…”
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Nuclear Accumulation of Prohibitin 1 in Osteoarthritic Chondrocytes Down‐Regulates PITX1 Expression by Picard, Cynthia, Pellicelli, Martin, Taheri, Maryam, Lavoie, Jean‐Francois, Doucet, Roxanne, Wang, DaShen, Bernard, Lauriane, Bouhanik, Saadallah, Lavigne, Patrick, Moreau, Alain

“…Objective To decipher the molecular mechanisms down‐regulating PITX1 expression in primary osteoarthritis (OA). Methods The functional activity of different…”
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