Search Results - "Pelletier, Martin"

The impact and toxicity of glyphosate and glyphosate-based herbicides on health and immunity by Peillex, Cindy, Pelletier, Martin

“…Glyphosate, or N-phosphomethyl(glycine), is an organophosphorus compound and a competitive inhibitor of the shikimate pathway that allows aromatic amino acid…”
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Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS) by Bulua, Ariel C, Simon, Anna, Maddipati, Ravikanth, Pelletier, Martin, Park, Heiyoung, Kim, Kye-Young, Sack, Michael N, Kastner, Daniel L, Siegel, Richard M

“…Reactive oxygen species (ROS) have an established role in inflammation and host defense, as they kill intracellular bacteria and have been shown to activate…”
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Evidence for a cross-talk between human neutrophils and Th17 cells by Pelletier, Martin, Maggi, Laura, Micheletti, Alessandra, Lazzeri, Elena, Tamassia, Nicola, Costantini, Claudio, Cosmi, Lorenzo, Lunardi, Claudio, Annunziato, Francesco, Romagnani, Sergio, Cassatella, Marco A.

“…Interleukin-17A (IL-17A) and IL-17F are 2 of several cytokines produced by T helper 17 cells (Th17), which are able to indirectly induce the recruitment of…”
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Critical role of fatty acid metabolism in ILC2-mediated barrier protection during malnutrition and helminth infection by Wilhelm, Christoph, Harrison, Oliver J, Schmitt, Vanessa, Pelletier, Martin, Spencer, Sean P, Urban, Jr, Joseph F, Ploch, Michelle, Ramalingam, Thirumalai R, Siegel, Richard M, Belkaid, Yasmine

“…Innate lymphoid cells (ILC) play an important role in many immune processes, including control of infections, inflammation, and tissue repair. To date, little…”
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Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production by Brehm, Anja, Liu, Yin, Sheikh, Afzal, Marrero, Bernadette, Omoyinmi, Ebun, Zhou, Qing, Montealegre, Gina, Biancotto, Angelique, Reinhardt, Adam, Almeida de Jesus, Adriana, Pelletier, Martin, Tsai, Wanxia L, Remmers, Elaine F, Kardava, Lela, Hill, Suvimol, Kim, Hanna, Lachmann, Helen J, Megarbane, Andre, Chae, Jae Jin, Brady, Jilian, Castillo, Rhina D, Brown, Diane, Casano, Angel Vera, Gao, Ling, Chapelle, Dawn, Huang, Yan, Stone, Deborah, Chen, Yongqing, Sotzny, Franziska, Lee, Chyi-Chia Richard, Kastner, Daniel L, Torrelo, Antonio, Zlotogorski, Abraham, Moir, Susan, Gadina, Massimo, McCoy, Phil, Wesley, Robert, Rother, Kristina I, Rother, Kristina, Hildebrand, Peter W, Brogan, Paul, Krüger, Elke, Aksentijevich, Ivona, Goldbach-Mansky, Raphaela

“…Autosomal recessive mutations in proteasome subunit β 8 (PSMB8), which encodes the inducible proteasome subunit β5i, cause the immune-dysregulatory disease…”
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Estrogens and endocrine-disrupting chemicals differentially impact the bioenergetic fluxes of mammary epithelial cells in two- and three-dimensional models by Lacouture, Aurélie, Breton, Yann, Weidmann, Cindy, Goulet, Sarah-Maude, Germain, Lucas, Pelletier, Martin, Audet-Walsh, Étienne

“…[Display omitted] •We optimized bioenergetic flux assays in 2D and 3D models of the mammary gland.•Estrogens and EDCs reprogram mammary epithelial cell energy…”
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Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects by Traba, Javier, Kwarteng-Siaw, Miriam, Okoli, Tracy C, Li, Jessica, Huffstutler, Rebecca D, Bray, Amanda, Waclawiw, Myron A, Han, Kim, Pelletier, Martin, Sauve, Anthony A, Siegel, Richard M, Sack, Michael N

“…Activation of the NLRP3 inflammasome is associated with metabolic dysfunction, and intermittent fasting has been shown to improve clinical presentation of…”
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Extracellular flux analysis to monitor glycolytic rates and mitochondrial oxygen consumption by Pelletier, Martin, Billingham, Leah K, Ramaswamy, Madhu, Siegel, Richard M

“…Evidence accumulating over the past decade has linked alterations in bioenergetic metabolism to the pathogenesis of several diseases, including inflammatory…”
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Toll‐Like Receptor‐3‐Activated Human Mesenchymal Stromal Cells Significantly Prolong the Survival and Function of Neutrophils by Cassatella, Marco A., Mosna, Federico, Micheletti, Alessandra, Lisi, Veronica, Tamassia, Nicola, Cont, Caterina, Calzetti, Federica, Pelletier, Martin, Pizzolo, Giovanni, Krampera, Mauro

“…Bone marrow‐derived mesenchymal stromal cells (BM‐MSCs) are stromal precursors endowed with extensive immunomodulative properties. In this study, we aimed to…”
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Glucuronidated Metabolites of Bisphenols A and S Alter the Properties of Normal Urothelial and Bladder Cancer Cells by Pellerin, Ève, Pellerin, Félix-Antoine, Chabaud, Stéphane, Pouliot, Frédéric, Pelletier, Martin, Bolduc, Stéphane

“…Bisphenol A (BPA) and bisphenol S (BPS) are synthetic chemicals used to produce plastics which can be released in food and water. Once ingested, BPA and BPS…”
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The follicle-stimulating hormone triggers rapid changes in mitochondrial structure and function in porcine cumulus cells by Lounas, Amel, Breton, Yann, Lebrun, Ariane, Laflamme, Isabelle, Vernoux, Nathalie, Savage, Julie, Tremblay, Marie-Ève, Pelletier, Martin, Germain, Marc, Richard, François J.

“…Oocyte maturation is a key process during which the female germ cell undergoes resumption of meiosis and completes its preparation for embryonic development…”
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Recruitment of A20 by the C-terminal domain of NEMO suppresses NF-κB activation and autoinflammatory disease by Zilberman-Rudenko, Jevgenia, Shawver, Linda Monaco, Wessel, Alex W., Luo, Yongquan, Pelletier, Martin, Tsai, Wanxia Li, Lee, Younglang, Vonortas, Spiridon, Cheng, Laurence, Ashwell, Jonathan D., Orange, Jordan S., Siegel, Richard M., Hanson, Eric P.

“…Receptor-induced NF-κB activation is controlled by NEMO, the NF-κB essential modulator. Hypomorphic NEMO mutations result in X-linked ectodermal dysplasia with…”
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Rebaudioside D decreases adiposity and hepatic lipid accumulation in a mouse model of obesity by Morissette, Arianne, de Wouters d’Oplinter, Alice, Andre, Diana Majolli, Lavoie, Marilou, Marcotte, Bruno, Varin, Thibault V., Trottier, Jocelyn, Pilon, Geneviève, Pelletier, Martin, Cani, Patrice D., Barbier, Olivier, Houde, Vanessa P., Marette, André

“…Overconsumption of added sugars has been pointed out as a major culprit in the increasing rates of obesity worldwide, contributing to the rising popularity of…”
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Prevalence of Mycoplasma synoviae and Its Impact on Productivity in Commercial Poultry Farms in Quebec, Canada by Bergeron, Nadia, Hébert, Ghislain, Pelletier, Martin C, Cai, Hugh Y, Brochu-Morin, Marie-Eve, Vaillancourt, Jean-Pierre

“…(MS) is associated with upper respiratory disease, joint, and reproductive system disease in poultry. Economic losses are due to stunting, increased mortality,…”
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A FACS-Free Purification Method to Study Estrogen Signaling, Organoid Formation, and Metabolic Reprogramming in Mammary Epithelial Cells by Lacouture, Aurélie, Jobin, Cynthia, Weidmann, Cindy, Berthiaume, Line, Bastien, Dominic, Laverdière, Isabelle, Pelletier, Martin, Audet-Walsh, Étienne

“…Few models are used to study mammary epithelial cells (MECs), and most of these do not express the estrogen receptor α (ERα). Primary MECs can be used to…”
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Isocitrate dehydrogenase 1 sustains a hybrid cytoplasmic-mitochondrial tricarboxylic acid cycle that can be targeted for therapeutic purposes in prostate cancer by Gonthier, Kevin, Weidmann, Cindy, Berthiaume, Line, Jobin, Cynthia, Lacouture, Aurélie, Lafront, Camille, Harvey, Mario, Neveu, Bertrand, Loehr, Jérémy, Bergeron, Alain, Fradet, Yves, Lacombe, Louis, Riopel, Julie, Latulippe, Éva, Atallah, Chantal, Shum, Michael, Lambert, Jean-Philippe, Pouliot, Frédéric, Pelletier, Martin, Audet-Walsh, Étienne

“…The androgen receptor (AR) is an established orchestrator of cell metabolism in prostate cancer (PCa), notably by inducing an oxidative mitochondrial program…”
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Expression of the myeloid inhibitory receptor CLEC12A correlates with disease activity and cytokines in early rheumatoid arthritis by Vaillancourt, Myriam, Desaulniers, Philippe, Paré, Guillaume, Pagé, Nathalie, Lachhab, Asmaa, Kerever, Anthony, Julien, Anne-Sophie, Amiable, Nathalie, Pelletier, Martin, Tessier, Philippe A., Bessette, Louis, Michou, Laëtitia, Fortin, Paul R., Fernandes, Maria J.

“…The myeloid inhibitory receptor CLEC12A negatively regulates inflammation. Reduced CLEC12A expression enhances inflammation in CLEC12A knock-out mice with…”
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Modulation of human neutrophil survival and antigen expression by activated CD4+ and CD8+ T cells by Pelletier, Martin, Micheletti, Alessandra, Cassatella, Marco A.

“…CD8+ T cells modulate neutrophil apoptosis and surface marker expression via TNF‐α, IFN‐γ and GM‐CSF, while CD4+ T cells effects involve IFN‐γ and GM‐CSF…”
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New tricks from an old dog: Mitochondrial redox signaling in cellular inflammation by Pelletier, Martin, Lepow, Talya S, Billingham, Leah K, Murphy, Michael P, Siegel, Richard M

“…Highlights ► In addition to host defense and cellular damage, ROS can act as signaling molecules. ► Mitochondrial ROS production is dependent on the metabolic…”
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S100A9 potentiates the activation of neutrophils by the etiological agent of gout, monosodium urate crystals by Rousseau, Louis‐Simon, Paré, Guillaume, Lachhab, Asmaa, Naccache, Paul H., Marceau, François, Tessier, Philippe, Pelletier, Martin, Fernandes, Maria

“…S100A9 enhances the response of neutrophils to monosodium urate crystals; the implications for gout. Gout is one of the most painful types of arthritis that…”
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