Search Results - "Pellegrini‐Giampietro, D E"

Long‐lasting neuroprotection and neurological improvement in stroke models with new, potent and brain permeable inhibitors of poly(ADP‐ribose) polymerase by Moroni, F, Cozzi, A, Chiarugi, A, Formentini, L, Camaioni, E, Pellegrini‐Giampietro, DE, Chen, Y, Liang, S, Zaleska, MM, Gonzales, C, Wood, A, Pellicciari, R

“…BACKGROUND AND PURPOSES Thienyl‐isoquinolone (TIQ‐A) is a relatively potent PARP inhibitor able to reduce post‐ischaemic neuronal death in vitro. Here we have…”
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Selective PARP‐2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post‐ischaemic brain damage by Moroni, F, Formentini, L, Gerace, E, Camaioni, E, Pellegrini‐Giampietro, D E, Chiarugi, A, Pellicciari, R

“…Background and purpose:  Poly(ADP‐ribose) polymerases (PARP)‐1 and PARP‐2 play complementary tasks in the maintenance of genomic integrity, but their role in…”
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The expression of glutamate transporter GLT-1 in the rat cerebral cortex is down-regulated by the antipsychotic drug clozapine by MELONE, M, VITELLARO-ZUCCARELLO, L, VALLEJO-ILLARRAMENDI, A, PEREZ-SAMARTIN, A, MATUTE, C, COZZI, A, PELLEGRINI-GIAMPIETRO, D. E, ROTHSTEIN, J. D, CONTI, F

“…We show here that clozapine, a beneficial antipsychotic, down-regulates the expression of the glutamate transporter GLT-1 in the rat cerebral cortex, thereby…”
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Glutamate receptor and transporter modifications in rat organotypic hippocampal slice cultures exposed to oxygen–glucose deprivation: The contribution of cyclooxygenase-2 by Llorente, I.L, Landucci, E, Pellegrini-Giampietro, D.E, Fernández-López, A

“…Graphical abstract…”
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Differential Expression of Three Glutamate Receptor Genes in Developing Rat Brain: An in situ Hybridization Study by Pellegrini-Giampietro, Domenico E., Michael V. L. Bennett, Zukin, R. Suzanne

“…Non-N-methyl-D-aspartate glutamate receptors (GluRs) are encoded by a gene family, known members of which are designated GluR-1, -2, -3, -4, and -5. The…”
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Poly(ADP-ribose) polymerase inhibitors attenuate necrotic but not apoptotic neuronal death in experimental models of cerebral ischemia by Moroni, F, Meli, E, Peruginelli, F, Chiarugi, A, Cozzi, A, Picca, R, Romagnoli, P, Pellicciari, R, Pellegrini-Giampietro, D E

“…An excessive activation of poly(ADP-ribose) polymerase (PARP) has been proposed to play a key role in post-ischemic neuronal death. We examined the…”
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Pharmacological characterization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus by Pellegrini‐Giampietro, Domenico E., Torregrossa, Serenella Albani, Moroni, Flavio

“…1 Phospholipase D (PLD) is the key enzyme in a signal transduction pathway leading to the formation of the second messengers phosphatidic acid and…”
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PARP-1 activation causes neuronal death in the hippocampal CA1 region by increasing the expression of Ca(2+)-permeable AMPA receptors by Gerace, E, Masi, A, Resta, F, Felici, R, Landucci, E, Mello, T, Pellegrini-Giampietro, D E, Mannaioni, G, Moroni, F

“…An excessive activation of poly(ADP-ribose) polymerases (PARPs) may trigger a form of neuronal death similar to that occurring in neurodegenerative disorders…”
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Switch in Glutamate Receptor Subunit Gene Expression in CA1 Subfield of Hippocampus Following Global Ischemia in Rats by Pellegrini-Giampietro, Domenico E., Zukin, R. Suzanne, Michael V. L. Bennett, Cho, Sunghee, Pulsinelli, William A.

“…Severe, transient global ischemia of the brain induces delayed damage to specific neuronal populations. Sustained Ca2+influx through glutamate receptor…”
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Calcium channel inhibitors suppress the morphine‐withdrawal syndrome in rats by Bongianni, F., Carla', V., Moroni, F., Pellegrini‐Giampietro, D.E.

“…1 The effects of the Ca2+‐channel blockers verapamil and nimodipine, on the behavioural signs of naloxone (1 mg kg−1)‐induced abstinence syndrome in…”
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Kainate-induced status epilepticus alters glutamate and GABAA receptor gene expression in adult rat hippocampus: an in situ hybridization study by Friedman, LK, Pellegrini-Giampietro, DE, Sperber, EF, Bennett, MV, Moshe, SL, Zukin, RS

“…In adult rats, intraperitoneal administration of kainic acid, a glutamic acid analog and potent neurotoxin, induces persistent seizure activity that results in…”
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Excitatory amino acid release and free radical formation may cooperate in the genesis of ischemia-induced neuronal damage by Pellegrini-Giampietro, DE, Cherici, G, Alesiani, M, Carla, V, Moroni, F

“…Excessive stimulation of excitatory amino acid (EAA) receptors and abnormal production of oxygen-derived free radicals have repeatedly been implicated in the…”
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AMPA/kainate receptor gene expression in normal and Alzheimer's disease hippocampus by Pellegrini-Giampietro, D E, Bennett, M V, Zukin, R S

“…Alzheimer's disease is a progressive dementia characterized by pronounced degeneration of certain populations of neurons in the hippocampus and cerebral cortex…”
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Quinoxalines interact with the glycine recognition site of NMDA receptors: studies in guinea‐pig myenteric plexus and in rat cortical membranes by Pellegrini‐Giampietro, Domenico E., Galli, Alessandro, Alesiani, Marina, Cherici, Giovanna, Moroni, Flavio

“…1 The effects of several quinoxalines, including 6‐cyano‐7‐nitroquinoxaline‐2,3‐dione (CNQX) and 6,7,dinitroquinoxaline‐2,3‐dione (DNQX), and of two…”
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Excitatory amino acid release from rat hippocampal slices as a consequence of free-radical formation by Pellegrini-Giampietro, D E, Cherici, G, Alesiani, M, Carlà, V, Moroni, F

“…The release of D-[3H]aspartate, [3H]noradrenaline, and of endogenous glutamate and aspartate from rat hippocampal slices was significantly increased when the…”
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(+)-MCPG induces PKCε translocation in cortical synaptosomes through a PLD-coupled mGluR by Pastorino, L., Colciaghi, F., Gardoni, F., Albani-Torregrossa, S., Pellegrini-Giampietro, D. E., Moroni, F., De Graan, P. N. E., Cattabeni, F., Di Luca, M.

“…We have tested whether different agonists of metabotropic glutamate receptors could induce translocation of selective protein kinase C isozymes in nerve…”
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Protection with metabotropic glutamate 1 receptor antagonists in models of ischemic neuronal death: time-course and mechanisms by Pellegrini-Giampietro, Domenico E., Peruginelli, Fiamma, Meli, Elena, Cozzi, Andrea, Albani-Torregrossa, Serenella, Pellicciari, Roberto, Moroni, Flavio

“…In order to study the role of metabotropic glutamate 1 (mGlu1) receptors in ischemic neuronal death, we examined the effects of the recently characterized and…”
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Glutamate receptor gene expression in spinal cord of arthritic rats by Pellegrini-Giampietro, DE, Fan, S, Ault, B, Miller, BE, Zukin, RS

“…Injury to peripheral tissue leads to hyperalgesia that appears to be partly mediated by functional changes at the level of the spinal cord. Glutamate receptors…”
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Lesioning and recovery of the serotoninergic projections to the hippocampus by Lombardi, G, Gandolfi, O, Dall'Olio, R, Pellegrini-Giampietro, D E, Beni, M, Carla, V, Consolazione, A, Moroni, F

“…The time course of the changes of the hippocampal 5-hydroxytryptamine (5-HT) system after a lesion of the dorsal afferents to this brain area was studied by…”
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1-Aminoindan-1,5-dicarboxylic acid and (S)-(+)-2-(3′-carboxybicyclo[1.1.1] pentyl)-glycine, two mGlu1 receptor-preferring antagonists, reduce neuronal death in in vitro and in vivo models of cerebral ischaemia by Pellegrini-Giampietro, Domenico E., Cozzi, Andrea, Peruginelli, Fiamma, Leonardi, Patrizia, Meli, Elena, Pellicciari, Roberto, Moroni, Flavio

“…Metabotropic glutamate (mGlu) receptors have been implicated in a number of physiological and pathological responses to glutamate, but the exact role of group…”
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