Search Results - "Pellegrini, Marc"

Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes by Mackay, Laura K., Minnich, Martina, Kragten, Natasja A. M., Liao, Yang, Nota, Benjamin, Seillet, Cyril, Zaid, Ali, Man, Kevin, Preston, Simon, Freestone, David, Braun, Asolina, Wynne-Jones, Erica, Behr, Felix M., Stark, Regina, Pellicci, Daniel G., Godfrey, Dale I., Belz, Gabrielle T., Pellegrini, Marc, Gebhardt, Thomas, Busslinger, Meinrad, Shi, Wei, Carbone, Francis R., van Lier, René A. W., Kallies, Axel, van Gisbergen, Klaas P. J. M.

“…Tissue-resident memory T (Trm) cells permanently localize to portals of pathogen entry, where they provide immediate protection against reinfection. To enforce…”
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Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection by Doerflinger, Marcel, Deng, Yexuan, Whitney, Paul, Salvamoser, Ranja, Engel, Sven, Kueh, Andrew J., Tai, Lin, Bachem, Annabell, Gressier, Elise, Geoghegan, Niall D., Wilcox, Stephen, Rogers, Kelly L., Garnham, Alexandra L., Dengler, Michael A., Bader, Stefanie M., Ebert, Gregor, Pearson, Jaclyn S., De Nardo, Dominic, Wang, Nancy, Yang, Chenying, Pereira, Milton, Bryant, Clare E., Strugnell, Richard A., Vince, James E., Pellegrini, Marc, Strasser, Andreas, Bedoui, Sammy, Herold, Marco J.

“…Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necroptosis, and apoptosis during…”
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Effector and stem-like memory cell fates are imprinted in distinct lymph node niches directed by CXCR3 ligands by Duckworth, Brigette C., Lafouresse, Fanny, Wimmer, Verena C., Broomfield, Benjamin J., Dalit, Lennard, Alexandre, Yannick O., Sheikh, Amania A., Qin, Raymond Z., Alvarado, Carolina, Mielke, Lisa A., Pellegrini, Marc, Mueller, Scott N., Boudier, Thomas, Rogers, Kelly L., Groom, Joanna R.

“…T cells dynamically interact with multiple, distinct cellular subsets to determine effector and memory differentiation. Here, we developed a platform to…”
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Macrophage and neutrophil death programs differentially confer resistance to tuberculosis by Stutz, Michael Dominic, Allison, Cody Charles, Ojaimi, Samar, Preston, Simon Peter, Doerflinger, Marcel, Arandjelovic, Philip, Whitehead, Lachlan, Bader, Stefanie M., Batey, Daniel, Asselin-Labat, Marie-Liesse, Herold, Marco J., Strasser, Andreas, West, Nicholas P., Pellegrini, Marc

“…Apoptosis can potently defend against intracellular pathogens by directly killing microbes and eliminating their replicative niche. However, the reported…”
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Severe Malaria Infections Impair Germinal Center Responses by Inhibiting T Follicular Helper Cell Differentiation by Ryg-Cornejo, Victoria, Ioannidis, Lisa Julia, Ly, Ann, Chiu, Chris Yu, Tellier, Julie, Hill, Danika Lea, Preston, Simon Peter, Pellegrini, Marc, Yu, Di, Nutt, Stephen Laurence, Kallies, Axel, Hansen, Diana Silvia

“…Naturally acquired immunity to malaria develops only after years of repeated exposure to Plasmodium parasites. Despite the key role antibodies play in…”
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Eliminating hepatitis B by antagonizing cellular inhibitors of apoptosis by Ebert, Gregor, Allison, Cody, Preston, Simon, Cooney, James, Toe, Jesse G., Stutz, Michael D., Ojaimi, Samar, Baschuk, Nikola, Nachbur, Ueli, Torresi, Joseph, Silke, John, Begley, C. Glenn, Pellegrini, Marc

“…We have shown that cellular inhibitor of apoptosis proteins (cIAPs) impair clearance of hepatitis B virus (HBV) infection by preventing TNF-mediated…”
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A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction by Hildebrand, Joanne M., Kauppi, Maria, Majewski, Ian J., Liu, Zikou, Cox, Allison J., Miyake, Sanae, Petrie, Emma J., Silk, Michael A., Li, Zhixiu, Tanzer, Maria C., Brumatti, Gabriela, Young, Samuel N., Hall, Cathrine, Garnish, Sarah E., Corbin, Jason, Stutz, Michael D., Di Rago, Ladina, Gangatirkar, Pradnya, Josefsson, Emma C., Rigbye, Kristin, Anderton, Holly, Rickard, James A., Tripaydonis, Anne, Sheridan, Julie, Scerri, Thomas S., Jackson, Victoria E., Czabotar, Peter E., Zhang, Jian-Guo, Varghese, Leila, Allison, Cody C., Pellegrini, Marc, Tannahill, Gillian M., Hatchell, Esme C., Willson, Tracy A., Stockwell, Dina, de Graaf, Carolyn A., Collinge, Janelle, Hilton, Adrienne, Silke, Natasha, Spall, Sukhdeep K., Chau, Diep, Athanasopoulos, Vicki, Metcalf, Donald, Laxer, Ronald M., Bassuk, Alexander G., Darbro, Benjamin W., Fiatarone Singh, Maria A., Vlahovich, Nicole, Hughes, David, Kozlovskaia, Maria, Ascher, David B., Warnatz, Klaus, Venhoff, Nils, Thiel, Jens, Biben, Christine, Blum, Stefan, Reveille, John, Hildebrand, Michael S., Vinuesa, Carola G., McCombe, Pamela, Brown, Matthew A., Kile, Benjamin T., McLean, Catriona, Bahlo, Melanie, Masters, Seth L., Nakano, Hiroyasu, Ferguson, Polly J., Murphy, James M., Alexander, Warren S., Silke, John

“…MLKL is the essential effector of necroptosis, a form of programmed lytic cell death. We have isolated a mouse strain with a single missense mutation, Mlkl…”
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FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal by You, Han, Pellegrini, Marc, Tsuchihara, Katsuya, Yamamoto, Kazuo, Hacker, Georg, Erlacher, Miriam, Villunger, Andreas, Mak, Tak W

“…Puma is an essential mediator of p53-dependent and -independent apoptosis in vivo. In response to genotoxic stress, Puma is induced in a p53-dependent manner…”
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IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology by Pellegrini, Marc, Calzascia, Thomas, Toe, Jesse G., Preston, Simon P., Lin, Amy E., Elford, Alisha R., Shahinian, Arda, Lang, Philipp A., Lang, Karl S., Morre, Michel, Assouline, Brigitte, Lahl, Katharina, Sparwasser, Tim, Tedder, Thomas F., Paik, Ji-hye, DePinho, Ronald A., Basta, Sameh, Ohashi, Pamela S., Mak, Tak W.

“…Understanding the factors that impede immune responses to persistent viruses is essential in designing therapies for HIV infection. Mice infected with LCMV…”
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Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus by Ebert, Gregor, Preston, Simon, Allison, Cody, Cooney, James, Toe, Jesse G., Stutz, Michael D., Ojaimi, Samar, Scott, Hamish W., Baschuk, Nikola, Nachbur, Ueli, Torresi, Joseph, Chin, Ruth, Colledge, Danielle, Li, Xin, Warner, Nadia, Revill, Peter, Bowden, Scott, Silke, John, Begley, C. Glenn, Pellegrini, Marc

“…Significance Hepatitis B virus (HBV) causes substantial morbidity and mortality. A large proportion of infected individuals controls infection but does not…”
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Necroptosis does not drive disease pathogenesis in a mouse infective model of SARS-CoV-2 in vivo by M. Bader, Stefanie, Cooney, James P., Bhandari, Reet, Mackiewicz, Liana, Dayton, Merle, Sheerin, Dylan, Georgy, Smitha Rose, Murphy, James M., Davidson, Kathryn C., Allison, Cody C., Pellegrini, Marc, Doerflinger, Marcel

“…Necroptosis, a type of lytic cell death executed by the pseudokinase Mixed Lineage Kinase Domain-Like (MLKL) has been implicated in the detrimental…”
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Context-Dependent Role for T-bet in T Follicular Helper Differentiation and Germinal Center Function following Viral Infection by Sheikh, Amania A., Cooper, Lucy, Feng, Meiqi, Souza-Fonseca-Guimaraes, Fernando, Lafouresse, Fanny, Duckworth, Brigette C., Huntington, Nicholas D., Moon, James J., Pellegrini, Marc, Nutt, Stephen L., Belz, Gabrielle T., Good-Jacobson, Kim L., Groom, Joanna R.

“…Following infection, inflammatory cues upregulate core transcriptional programs to establish pathogen-specific protection. In viral infections, T follicular…”
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Marine sponge microbe provides insights into evolution and virulence of the tubercle bacillus by Pidot, Sacha J, Klatt, Stephan, Ates, Louis S, Frigui, Wafa, Sayes, Fadel, Majlessi, Laleh, Izumi, Hiroshi, Monk, Ian R, Porter, Jessica L, Bennett-Wood, Vicki, Seemann, Torsten, Otter, Ashley, Taiaroa, George, Cook, Gregory M, West, Nicholas, Tobias, Nicholas J, Fuerst, John A, Stutz, Michael D, Pellegrini, Marc, McConville, Malcolm, Brosch, Roland, Stinear, Timothy P

“…Reconstructing the evolutionary origins of Mycobacterium tuberculosis, the causative agent of human tuberculosis, has helped identify bacterial factors that…”
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Combinatorial Treatment of Birinapant and Zosuquidar Enhances Effective Control of HBV Replication In Vivo by Morrish, Emma, Mackiewicz, Liana, Silke, Natasha, Pellegrini, Marc, Silke, John, Brumatti, Gabriela, Ebert, Gregor

“…Chronic hepatitis B virus (HBV) infection remains a global health threat and affects hundreds of millions worldwide. Small molecule compounds that mimic…”
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A human model of Buruli ulcer: The case for controlled human infection and considerations for selecting a Mycobacterium ulcerans challenge strain by Muhi, Stephen, Osowicki, Joshua, O'Brien, Daniel, Johnson, Paul D R, Pidot, Sacha, Doerflinger, Marcel, Marshall, Julia L, Pellegrini, Marc, McCarthy, James, Stinear, Timothy P

“…Critical knowledge gaps regarding infection with Mycobacterium ulcerans, the cause of Buruli ulcer (BU), have impeded development of new therapeutic approaches…”
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Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways by Josefsson, Emma C., Burnett, Deborah L., Lebois, Marion, Debrincat, Marlyse A., White, Michael J., Henley, Katya J., Lane, Rachael M., Moujalled, Diane, Preston, Simon P., O’Reilly, Lorraine A., Pellegrini, Marc, Metcalf, Donald, Strasser, Andreas, Kile, Benjamin T.

“…BH3 mimetic drugs that target BCL-2 family pro-survival proteins to induce tumour cell apoptosis represent a new era in cancer therapy. Clinical trials of…”
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Is Receptor-Interacting Protein Kinase 3 a Viable Therapeutic Target for Mycobacterium tuberculosis Infection? by Stutz, Michael D, Ojaimi, Samar, Ebert, Gregor, Pellegrini, Marc

“…The dwindling list of antimicrobial agents exhibiting broad efficacy against clinical strains of (Mtb) has forced the medical community to redefine current…”
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Targeting the Extrinsic Pathway of Hepatocyte Apoptosis Promotes Clearance of Plasmodium Liver Infection by Ebert, Gregor, Lopaticki, Sash, O’Neill, Matthew T., Steel, Ryan W.J., Doerflinger, Marcel, Rajasekaran, Pravin, Yang, Annie S.P., Erickson, Sara, Ioannidis, Lisa, Arandjelovic, Philip, Mackiewicz, Liana, Allison, Cody, Silke, John, Pellegrini, Marc, Boddey, Justin A.

“…Plasmodium sporozoites infect the liver and develop into exoerythrocytic merozoites that initiate blood-stage disease. The hepatocyte molecular pathways that…”
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Shutdown of an Acute T Cell Immune Response to Viral Infection Is Mediated by the Proapoptotic Bcl-2 Homology 3-Only Protein Bim by Pellegrini, Marc, Belz, Gabrielle, Bouillet, Philippe, Strasser, Andreas

“…We used mutant Fas-deficient (lpr) or Bim-deficient mice to investigate the role of the death receptor and Bcl-2-regulated apoptotic pathways in terminating a…”
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RUNX2 Mediates Plasmacytoid Dendritic Cell Egress from the Bone Marrow and Controls Viral Immunity by Chopin, Michaël, Preston, Simon P., Lun, Aaron T.L., Tellier, Julie, Smyth, Gordon K., Pellegrini, Marc, Belz, Gabrielle T., Corcoran, Lynn M., Visvader, Jane E., Wu, Li, Nutt, Stephen L.

“…Plasmacytoid dendritic cells (pDCs) represent a unique immune cell type that responds to viral nucleic acids through the rapid production of type I…”
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