Search Results - "Pelleg, Amir"

Degranulation of human mast cells: modulation by P2 receptors’ agonists by Schulman, Edward S., Nishi, Haruhisa, Pelleg, Amir

“…Since the late 1970s, there has been an alarming increase in the incidence of asthma and its morbidity and mortality. Acute obstruction and inflammation of…”
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DT-0111: a novel P2X3 receptor antagonist by Pelleg, Amir, Sirtori, Elena, Rolland, Jean-Francois, Mahadevan, Anu

“…Extracellular adenosine 5’-triphosphate (ATP) acts as an autocrine and paracrine agent, the actions of which on affected cells are mediated by P2 receptors…”
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DT-0111: a novel drug-candidate for the treatment of COPD and chronic cough by Pelleg, Amir, Xu, Fadi, Zhuang, Jianguo, Undem, Bradley, Burnstock, Geoffrey

“…Background: Extracellular adenosine 5′-triphosphate (ATP) plays important mechanistic roles in pulmonary disorders in general and chronic obstructive pulmonary…”
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Extracellular Adenosine 5'-Triphosphate in Obstructive Airway Diseases by Pelleg, Amir, PhD, Schulman, Edward S., MD, Barnes, Peter J., DM, Master FCCP

“…In recent years, numerous studies have generated data supporting the hypothesis that extracellular adenosine 5′-triphosphate (ATP) plays a major role in…”
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Adenosine 5'-triphosphate's role in bradycardia and syncope associated with pulmonary embolism by Pelleg, Amir, Schulman, Edward S, Barnes, Peter J

“…Adenosine 5'-triphiosphate (ATP) is released from cells under physiologic and pathophysiologic conditions. Extracellular ATP acts as an autocrine and paracrine…”
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Effects of Aerosolized Adenosine 5′-Triphosphate in Smokers and Patients With COPD by Basoglu, Ozen K., MD, Barnes, Peter J., DM, DSc, Master FCCP, Kharitonov, Sergei A., MD, Pelleg, Amir, PhD

“…BACKGROUND Extracellular adenosine 5′-triphosphate (ATP) stimulates vagal C and Ad fibers in the lung, resulting in pronounced bronchoconstriction and cough…”
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The Mechanism of the Negative Chronotropic and Dromotropic Actions of Adenosine 5ʼ-triphosphate in the Heart: An Update by Pelleg, Amir, Belhassen, Bernard

“…Adenosine 5ʼ-triphosphate (ATP) plays a critical role in intracellular metabolism and energetics. Extracellular ATP is rapidly degraded to adenosine by…”
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Extracellular adenosine 5′-triphosphate in pulmonary disorders by Pelleg, Amir

“…[Display omitted] Adenosine 5′-triphosphate (ATP) is found in every cell of the human body where it plays a critical role in cellular energetics and…”
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Contrasting effects of ATP and adenosine on capsaicin challenge in asthmatic patients by Basoglu, Ozen K., MD, Pelleg, Amir, PhD, Kharitonov, Sergei A., MD, Barnes, Peter J., Master FRS

“…Abstract Background Adenosine 5’-triphosphate (ATP) stimulates pulmonary vagal slow conducting C-fibres and fast conducting Aδ-fibres with rapidly adapting…”
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Cardiac purinergic signalling in health and disease by Burnstock, Geoffrey, Pelleg, Amir

“…This review is a historical account about purinergic signalling in the heart, for readers to see how ideas and understanding have changed as new experimental…”
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Electrophysiologic effects of adenosine versus ATP by Pelleg, Amir

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Adenosine 5'-triphosphate axis in obstructive airway diseases by Pelleg, Amir, Schulman, Edward S

“…In recent years, significant progress has been made in our understanding of the pathophysiology behind obstructive airway diseases in general and asthma in…”
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Intralaryngeal application of ATP evokes apneic response mainly via acting on P2X3 (P2X2/3) receptors of the superior laryngeal nerve in postnatal rats by Zhuang, Jianguo, Gao, Xiuping, Wei, Wan, Pelleg, Amir, Xu, Fadi

“…Aerosolized ATP induces cough and bronchoconstriction via activating P2X3 and P2X2/3 receptors (P2X3R and P2X2/3R) localized on vagal pulmonary sensory fibers…”
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Effects of purine and pyrimidine nucleotides on intracellular Ca2+ in human eosinophils: Activation of purinergic P2Y receptors by Mohanty, Joy G., Raible, Donald G., McDermott, Lawrence J., Pelleg, Amir, Schulman, Edward S.

“…Background: Extracellular adenosine 5′-triphosphate (ATP) increases human eosinophil intracellular Ca2+ concentration; the mechanism of action is not fully…”
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Enhancement of Mast Cell Degranulation Mediated by Purinergic Receptors’ Activation and PI3K Type δ by Nishi, Haruhisa, Niyonsaba, François, Pelleg, Amir, Schulman, Edward S.

“…Abstract Mast cells express multiple metabotropic purinergic P2Y receptor (P2YR) subtypes. Few studies have evaluated their role in human mast cell (HMC)…”
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Autonomic Neural Control of Cardiac Function: Modulation by Adenosine and Adenosine 5′-Triphosphate by Pelleg, Amir, Katchanov, Guennadi, Xu, Jiang

“…Adenosine and adenosine 5′-triphosphate (ATP) are found in every cell of the human body. These molecules are released from cells into the extracellular fluid…”
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Adenosine receptors and the heart: role in regulation of coronary blood flow and cardiac electrophysiology by Mustafa, S Jamal, Morrison, R Ray, Teng, Bunyen, Pelleg, Amir

“…Adenosine is an autacoid that plays a critical role in regulating cardiac function, including heart rate, contractility, and coronary flow. In this chapter,…”
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IgE Receptor-Mediated Histamine Release in Human Lung Mast Cells: Modulation by Purinergic Receptor Ligands by Nishi, Haruhisa, Pelleg, Amir, Schulman, Edward S

“…Mast cells derived from human lungs (HLMCs) express multiple G-protein coupled purinergic receptors (P2YR) and the so-called α-ketoglutarate receptor GPR99,…”
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The pharmacology of adenosine by Pelleg, A, Porter, R S

“…Adenosine is a purine nucleoside present in every cell of the human body. It is released into the extracellular space under physiologic and pathophysiologic…”
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Age-related decline in beta adrenergic and adenosine A1 receptor function in the heart are attenuated by dietary restriction by Gao, E, Snyder, D L, Roberts, J, Friedman, E, Cai, G, Pelleg, A, Horwitz, J

“…Previously published reports from this laboratory have shown that the antiadrenergic effect of adenosine A1 agonists declines with age in the rat heart [ J Mol…”
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