Search Results - "Pelham, Hugh R B"

Arrestin-Mediated Endocytosis of Yeast Plasma Membrane Transporters by Nikko, Elina, Pelham, Hugh R.B

“…Many plasma membrane transporters in yeast are endocytosed in response to excess substrate or certain stresses and degraded in the vacuole. Endocytosis…”
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Arrestin-like proteins mediate ubiquitination and endocytosis of the yeast metal transporter Smf1 by Nikko, Elina, Sullivan, James A, Pelham, Hugh R B

“…Many plasma membrane proteins in yeast are ubiquitinated and endocytosed, but how they are recognized for modification has remained unknown. Here, we show that…”
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Towards accurate exclusion of neonatal bacterial meningitis: a feasibility study of a novel 16S rDNA PCR assay by Abelian, Arthur, Mund, Thomas, Curran, Martin D, Savill, Stuart A, Mitra, Nipa, Charan, Carol, Ogilvy-Stuart, Amanda L, Pelham, Hugh R. B, Dear, Paul H

“…PCRctic is an innovative assay based on 16S rDNA PCR technology that has been designed to detect a single intact bacterium in a specimen of cerebro-spinal…”
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Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins by Mund, Thomas, Pelham, Hugh R B

“…HECT domain E3 ubiquitin ligases of the NEDD4 family control many cellular processes, but their regulation is poorly understood. They contain multiple WW…”
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Inefficient quality control of thermosensitive proteins on the plasma membrane by Lewis, Michael J, Pelham, Hugh R B

“…Misfolded proteins are generally recognised by cellular quality control machinery, which typically results in their ubiquitination and degradation. For soluble…”
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Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2 by Mund, Thomas, Pelham, Hugh R. B., Brugge, Joan S.

“…Ndfip1 and Ndfip2 are related endosomal membrane proteins that bind to and activate members of the Nedd4 family of E3 ubiquitin ligases. These ligases in turn…”
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Disinhibition of the HECT E3 ubiquitin ligase WWP2 by polymerized Dishevelled by Mund, Thomas, Graeb, Michael, Mieszczanek, Juliusz, Gammons, Melissa, Pelham, Hugh R. B., Bienz, Mariann

“…Dishevelled is a pivot in Wnt signal transduction, controlling both β-catenin-dependent transcription to specify proliferative cell fates, and cell polarity…”
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A transmembrane ubiquitin ligase required to sort membrane proteins into multivesicular bodies by Pelham, Hugh R. B, Reggiori, Fulvio

“…Membrane proteins with transmembrane domains (TMDs) that contain polar residues exposed to the lipid bilayer are selectively sorted into multivesicular bodies…”
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Homotypic vacuolar fusion mediated by t- and v-SNAREs by Nichols, Benjamin J, Ungermann, Christian, Pelham, Hugh R. B, Wickner, William T, Haas, Albert

“…Membrane fusion is necessary both in the eukaryotic secretory pathway and for the inheritance of organelles during the cell cycle. In the secretory pathway,…”
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Structural Analysis of the Interaction Between the SNARE Tlg1 and Vps51 by Fridmann‐Sirkis, Yael, Kent, Helen M., Lewis, Michael J., Evans, Philip R., Pelham, Hugh R. B.

“…Membrane fusion in cells involves the interaction of SNARE proteins on apposing membranes. Formation of SNARE complexes is preceded by tethering events, and a…”
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Polar transmembrane domains target proteins to the interior of the yeast vacuole by Reggiori, F, Black, M W, Pelham, H R

“…Membrane proteins transported to the yeast vacuole can have two fates. Some reach the outer vacuolar membrane, whereas others enter internal vesicles, which…”
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A New Yeast Endosomal SNARE Related to Mammalian Syntaxin 8 by Lewis, Michael J., Pelham, Hugh R. B.

“…We report the identification of a yeast SNARE that has escaped notice because of an apparent error in the genome sequence and because it is functionally…”
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The syntaxin Tlg1p mediates trafficking of chitin synthase III to polarized growth sites in yeast by Holthuis, J C, Nichols, B J, Pelham, H R

“…Tlg1p and Tlg2p, members of the syntaxin family of SNAREs in yeast, have been implicated in both endocytosis and the retention of late Golgi markers. We have…”
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A SNARE-like protein required for traffic through the Golgi complex by Banfield, David K, Lewis, Michael J, Pelham, Hugh R. B

“…The secretory pathway of eukaryotic cells comprises several distinct membrane-bound compartments which are interconnected by transport vesicles that pinch off…”
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Bsd2 binds the ubiquitin ligase Rsp5 and mediates the ubiquitination of transmembrane proteins by Hettema, Ewald H, Valdez-Taubas, Javier, Pelham, Hugh R B

“…Membrane proteins destined for the vacuolar or lysosomal lumen are typically ubiquitinated, the ubiquitin serving as a targeting signal for the multivesicular…”
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Multiple interactions drive adaptor-mediated recruitment of the ubiquitin ligase rsp5 to membrane proteins in vivo and in vitro by Sullivan, James A, Lewis, Michael J, Nikko, Elina, Pelham, Hugh R B

“…Recognition of membrane proteins by the Nedd4/Rsp5 ubiquitin ligase family is a critical step in their targeting to the multivesicular body pathway. Some…”
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Vps51p Links the VFT Complex to the SNARE Tlg1p by Siniossoglou, Symeon, Pelham, Hugh R B

“…Intracellular membrane fusion requires the complex coordination of SNARE, rab/ypt, and rab effector function. In the yeast Saccharomyces cerevisiae , fusion of…”
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Heat shock factor is regulated differently in yeast and HeLa cells by Sorger, Peter K, Lewis, Michael J, Pelham, Hugh R. B

“…When cells are exposed to elevated temperatures, transcription of a small set of genes, the heat-shock genes, is activated. This response is mediated by a…”
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Specific retrieval of the exocytic SNARE Snc1p from early yeast endosomes by Lewis, M J, Nichols, B J, Prescianotto-Baschong, C, Riezman, H, Pelham, H R

“…Many endocytosed proteins in yeast travel to the vacuole, but some are recycled to the plasma membrane. We have investigated the recycling of chimeras…”
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Transferrin receptor-like proteins control the degradation of a yeast metal transporter by Stimpson, H.E.M, Lewis, M.J, Pelham, H.R.B

“…Plasma membrane transporters are often downregulated by their substrates. The yeast manganese transporter Smf1 is subject to two levels of regulation: heavy…”
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