Search Results - "Pelham, Christopher J."

Cell competition in tumor evolution and heterogeneity: Merging past and present by Pelham, Christopher J., Nagane, Masaki, Madan, Esha

“…In many cases, cancers are difficult to eliminate because they develop resistance to a primary chemotherapy or targeted therapy. Tumors grow into diverse cell…”
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Flower isoforms promote competitive growth in cancer by Madan, Esha, Pelham, Christopher J., Nagane, Masaki, Parker, Taylor M., Canas-Marques, Rita, Fazio, Kimberly, Shaik, Kranti, Yuan, Youzhong, Henriques, Vanessa, Galzerano, Antonio, Yamashita, Tadashi, Pinto, Miguel Alexandre Ferreira, Palma, Antonio M., Camacho, Denise, Vieira, Ana, Soldini, David, Nakshatri, Harikrishna, Post, Steven R., Rhiner, Christa, Yamashita, Hiroko, Accardi, Davide, Hansen, Laura A., Carvalho, Carlos, Beltran, Antonio L., Kuppusamy, Periannan, Gogna, Rajan, Moreno, Eduardo

“…In humans, the adaptive immune system uses the exchange of information between cells to detect and eliminate foreign or damaged cells; however, the removal of…”
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Cullin-3 Regulates Vascular Smooth Muscle Function and Arterial Blood Pressure via PPARγ and RhoA/Rho-Kinase by Pelham, Christopher J., Ketsawatsomkron, Pimonrat, Groh, Séverine, Grobe, Justin L., de Lange, Willem J., Ibeawuchi, Stella-Rita C., Keen, Henry L., Weatherford, Eric T., Faraci, Frank M., Sigmund, Curt D.

“…Dominant-negative (DN) mutations in the nuclear hormone receptor peroxisome proliferator-activated receptor-γ (PPARγ) cause hypertension by an unknown…”
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Sry-type HMG box 18 contributes to the differentiation of bone marrow-derived mesenchymal stem cells to endothelial cells by Ikhapoh, Izuagie Attairu, Pelham, Christopher J., Agrawal, Devendra K.

“…Mesenchymal stem cells (MSC) have shown therapeutic potential to engraft and either differentiate into or support differentiation of vascular endothelial cells…”
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Atherogenic Cytokines Regulate VEGF-A-Induced Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells into Endothelial Cells by Ikhapoh, Izuagie Attairu, Agrawal, Devendra K., Pelham, Christopher J.

“…Coronary artery stenting or angioplasty procedures frequently result in long-term endothelial dysfunction or loss and complications including arterial…”
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HIF-transcribed p53 chaperones HIF-1α by Madan, Esha, Parker, Taylor M, Pelham, Christopher J, Palma, Antonio M, Peixoto, Maria L, Nagane, Masaki, Chandaria, Aliya, Tomás, Ana R, Canas-Marques, Rita, Henriques, Vanessa, Galzerano, Antonio, Cabral-Teixeira, Joaquim, Selvendiran, Karuppaiyah, Kuppusamy, Periannan, Carvalho, Carlos, Beltran, Antonio, Moreno, Eduardo, Pati, Uttam K, Gogna, Rajan

“…Abstract Chronic hypoxia is associated with a variety of physiological conditions such as rheumatoid arthritis, ischemia/reperfusion injury, stroke, diabetic…”
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Emerging roles for triggering receptor expressed on myeloid cells receptor family signaling in inflammatory diseases by Pelham, Christopher J, Agrawal, Devendra K

“…Innate immune receptors represent important therapeutic targets for inflammatory disorders. In particular, the Toll-like receptor (TLR) family has emerged as a…”
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Vitamin D Controls Resistance Artery Function through Regulation of Perivascular Adipose Tissue Hypoxia and Inflammation by Pelham, Christopher J, Drews, Elizabeth M, Agrawal, Devendra K

“…Abstract Vitamin D deficiency in human subjects is associated with hypertension, metabolic syndrome and related risk factors of cardiovascular diseases. Serum…”
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Triggering receptor expressed on myeloid cells receptor family modulators: a patent review by Pelham, Christopher J, Pandya, Amit N, Agrawal, Devendra K

“…Triggering receptor expressed on myeloid cells (TREM) receptors and TREM-like transcript (TLT; or TREML) receptors of the immunoglobulin superfamily are known…”
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The curcumin analog HO-3867 selectively kills cancer cells by converting mutant p53 protein to transcriptionally active wildtype p53 by Madan, Esha, Parker, Taylor M., Bauer, Matthias R., Dhiman, Alisha, Pelham, Christopher J., Nagane, Masaki, Kuppusamy, M. Lakshmi, Holmes, Matti, Holmes, Thomas R., Shaik, Kranti, Shee, Kevin, Kiparoidze, Salome, Smith, Sean D., Park, Yu-Soon A., Gomm, Jennifer J., Jones, Louise J., Tomás, Ana R., Cunha, Ana C., Selvendiran, Karuppaiyah, Hansen, Laura A., Fersht, Alan R., Hideg, Kálmán, Gogna, Rajan, Kuppusamy, Periannan

“…p53 is an important tumor-suppressor protein that is mutated in more than 50% of cancers. Strategies for restoring normal p53 function are complicated by the…”
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Dominant negative PPARγ promotes atherosclerosis, vascular dysfunction, and hypertension through distinct effects in endothelium and vascular muscle by Pelham, Christopher J, Keen, Henry L, Lentz, Steven R, Sigmund, Curt D

“…Agonists of the nuclear hormone receptor peroxisome proliferator-activated receptor γ (PPARγ) have potent insulin-sensitizing effects and inhibit…”
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Role of peroxisome proliferator-activated receptor-γ in vascular muscle in the cerebral circulation by De Silva, T Michael, Modrick, Mary L, Ketsawatsomkron, Pimonrat, Lynch, Cynthia, Chu, Yi, Pelham, Christopher J, Sigmund, Curt D, Faraci, Frank M

“…Although peroxisome proliferator-activated receptor-γ (PPARγ) is thought to play a protective role in the vasculature, its cell-specific effect, particularly…”
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PPARγ Regulates Resistance Vessel Tone Through a Mechanism Involving RGS5-Mediated Control of Protein Kinase C and BKCa Channel Activity by Ketsawatsomkron, Pimonrat, Lorca, Ramón A, Keen, Henry L, Weatherford, Eric T, Liu, Xuebo, Pelham, Christopher J, Grobe, Justin L, Faraci, Frank M, England, Sarah K, Sigmund, Curt D

“…RATIONALE:Activation of peroxisome proliferator−activated receptor-γ (PPARγ) by thiazolidinediones lowers blood pressure, whereas PPARγ mutations cause…”
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Hypertension in mice with transgenic activation of the brain renin-angiotensin system is vasopressin dependent by Littlejohn, Nicole K, Siel, Jr, Rick B, Ketsawatsomkron, Pimonrat, Pelham, Christopher J, Pearson, Nicole A, Hilzendeger, Aline M, Buehrer, Beth A, Weidemann, Benjamin J, Li, Huiping, Davis, Deborah R, Thompson, Anthony P, Liu, Xuebo, Cassell, Martin D, Sigmund, Curt D, Grobe, Justin L

“…An indispensable role for the brain renin-angiotensin system (RAS) has been documented in most experimental animal models of hypertension. To identify the…”
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Synergistic effect of angiotensin II on vascular endothelial growth factor-A-mediated differentiation of bone marrow-derived mesenchymal stem cells into endothelial cells by Ikhapoh, Izuagie Attairu, Pelham, Christopher J, Agrawal, Devendra K

“…Increased levels of angiotensin II (Ang II) and activity of Ang II receptor type 1 (AT1R) elicit detrimental effects in cardiovascular disease. However, the…”
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Does Peroxisome Proliferator-activated Receptor-γ (PPARγ) Protect from Hypertension Directly through Effects in the Vasculature? by Ketsawatsomkron, Pimonrat, Pelham, Christopher J., Groh, Séverine, Keen, Henry L., Faraci, Frank M., Sigmund, Curt D.

“…Peroxisome proliferator-activated receptor-γ (PPARγ) is a ligand-activated transcription factor of the nuclear hormone receptor superfamily. Increasing…”
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Flower lose, a cell fitness marker, predicts COVID‐19 prognosis by Yekelchyk, Michail, Madan, Esha, Wilhelm, Jochen, Short, Kirsty R, Palma, António M, Liao, Linbu, Camacho, Denise, Nkadori, Everlyne, Winters, Michael T, Rice, Emily S, Rolim, Inês, Cruz‐Duarte, Raquel, Pelham, Christopher J, Nagane, Masaki, Gupta, Kartik, Chaudhary, Sahil, Braun, Thomas, Pillappa, Raghavendra, Parker, Mark S, Menter, Thomas, Matter, Matthias, Haslbauer, Jasmin Dionne, Tolnay, Markus, Galior, Kornelia D, Matkwoskyj, Kristina A, McGregor, Stephanie M, Muller, Laura K, Rakha, Emad A, Lopez‐Beltran, Antonio, Drapkin, Ronny, Ackermann, Maximilian, Fisher, Paul B, Grossman, Steven R, Godwin, Andrew K, Kulasinghe, Arutha, Martinez, Ivan, Marsh, Clay B, Tang, Benjamin, Wicha, Max S, Won, Kyoung Jae, Tzankov, Alexandar, Moreno, Eduardo, Gogna, Rajan

“…Risk stratification of COVID‐19 patients is essential for pandemic management. Changes in the cell fitness marker, hFwe‐Lose , can precede the host immune…”
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Pregnant mice lacking indoleamine 2,3‐dioxygenase exhibit preeclampsia phenotypes by Santillan, Mark K., Pelham, Christopher J., Ketsawatsomkron, Pimonrat, Santillan, Donna A., Davis, Deborah R., Devor, Eric J., Gibson‐Corley, Katherine N., Scroggins, Sabrina M., Grobe, Justin L., Yang, Baoli, Hunter, Steven K., Sigmund, Curt D.

“…Preeclampsia is a cardiovascular disorder of late pregnancy that is, commonly characterized by hypertension, renal structural damage and dysfunction, and fetal…”
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Preservation of Intracellular Renin Expression Is Insufficient to Compensate for Genetic Loss of Secreted Renin by Xu, Di, Borges, Giulianna R, Grobe, Justin L, Pelham, Christopher J, Yang, Baoli, Sigmund, Curt D

“…The primary product of the renin gene is preprorenin. A signal peptide sorts renin to the secretory pathway in juxtaglomerular cells where it is released into…”
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SPARC-p53: The double agents of cancer by Camacho, Denise, Jesus, Joana P, Palma, António M, Martins, Sofia A, Afonso, Alexandre, Peixoto, Maria Leonor, Pelham, Christopher J, Moreno, Eduardo, Gogna, Rajan

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