LYMPHOCYTE SUBPOPULATIONS OF BLOOD AND PLEURAL EXUDATE IN MBT-NEGATIVE AND MBT-POSITIVE TUBERCULOUS PLEURISY

Subpopulation indices of peripheral blood and pleural exudate lymphocytes have been studied in the patients with various clinical variants of a tuberculous pleurisy. It has been shown that, in patients with both MBT-negative and MBT-positive variants of tubercular pleurisy, decreased quantity of CD3...

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Published in:	Medit͡s︡inskai͡a︡ immunologii͡a Vol. 12; no. 4-5; pp. 325 - 330
Main Authors:	Jureva, E. A., Voronkova, O. V., Urazova, O. I., Novitsky, V. V., Nekrasov, E. V., Naslednikova, I. O., Maltseva, I. V., Peleganchuk, E. A., Pirogova, N. P.
Format:	Journal Article
Language:	English Russian
Published:	St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists 16-07-2014
Subjects:	blood lymphocyte subsets lymphocytes pleural exudate tuberculous pleuritis
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Summary:	Subpopulation indices of peripheral blood and pleural exudate lymphocytes have been studied in the patients with various clinical variants of a tuberculous pleurisy. It has been shown that, in patients with both MBT-negative and MBT-positive variants of tubercular pleurisy, decreased quantity of CD3- and CD4-positive lymphocytes was observed, whereas an increase in numbers of CD8+ and CD16+ lymphocytes was more pronounced in the persons with MBT-negative pleurisy. In pleural exudates from the patients with tubercular pleurisy, the numbers of CD3+ lymphocytes proved to be significantly higher than their contents in peripheral blood. It may be assumed that lymphocytosis in pleural exudates results from migration of the cells from peripheral blood into pleural cavity. It is revealed that, during exudative pleurisy of tuberculosis origin, T-cells with CD4+ and CD8+ phenotype are more likely subject to migration into pleural cavity, accomplished by additional migration of CD16+ lymphocytes in MBT-positive cases of pleurisy.
ISSN:	1563-0625 2313-741X
DOI:	10.15789/1563-0625-2010-4-5-325-330