Search Results - "Pelech, S."

Protein kinase and protein phosphatase expression in amyotrophic lateral sclerosis spinal cord by Hu, J.‐H., Zhang, H., Wagey, R., Krieger, C., Pelech, S. L.

“…The Kinetworks™ multi‐immunoblotting technique was used to evaluate the expressions of 78 protein kinases, 24 protein phosphatases and phosphorylation states…”
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Understanding prostate cancer biology using metabolomics and proteomics approaches: potentials in the improvement of the diagnosis, prognosis and identification of new therapeutic targets by Felgueiras, J, Vieira Silva, J, Nunes, A, Patrício, A, Pelech, S, Fardilha, M

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YB-1 evokes susceptibility to cancer through cytokinesis failure, mitotic dysfunction and HER2 amplification by Davies, A H, Barrett, I, Pambid, M R, Hu, K, Stratford, A L, Freeman, S, Berquin, I M, Pelech, S, Hieter, P, Maxwell, C, Dunn, S E

“…Y-box binding protein-1 (YB-1) expression in the mammary gland promotes breast carcinoma that demonstrates a high degree of genomic instability. In the present…”
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Activation of Phosphatidylinositol 3-Kinase, Protein Kinase B, and p70 S6 Kinases in Lipopolysaccharide-Stimulated Raw 264.7 Cells: Differential Effects of Rapamycin, Ly294002, and Wortmannin on Nitric Oxide Production by Salh, B, Wagey, R, Marotta, A, Tao, J. S, Pelech, S

“…Phosphatidylinositol 3-kinase (PI 3-kinase) and protein kinase B are critical players in cell proliferation and survival. Their downstream effector protein…”
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Coexpression of hepatocyte growth factor-Met : an early step in ovarian carcinogenesis? by WONG, A. S. T, PELECH, S. L, WOO, M. M. M, YIM, G, ROSEN, B, EHLEN, T, LEUNG, P. C. K, AUERSPERG, N

“…Since autocrine regulation of HGF-Met is implicated in many forms of human cancer, we investigated whether the predisposition to develop ovarian cancer in…”
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Ischemic Preconditioning Activates MAPKAPK2 in the Isolated Rabbit Heart: Evidence for Involvement of p38 MAPK by Nakano, Atsushi, Baines, Christopher P, Kim, Sung O, Pelech, Steven L, Downey, James M, Cohen, Michael V, Critz, Stuart D

“…ABSTRACTRecent studies suggest that p38 mitogen-activated protein kinase (MAPK) may be involved in ischemic preconditioning (PC). To further test this…”
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Isolation of various forms of sterol β‐d‐glucoside from the seed of Cycas circinalis: neurotoxicity and implications for ALS‐parkinsonism dementia complex by Khabazian, I., Bains, J. S., Williams, D. E., Cheung, J., Wilson, J. M. B., Pasqualotto, B. A., Pelech, S. L., Andersen, R. J., Wang, Y.‐T., Liu, L., Nagai, A., Kim, S. U., Craig, U‐K., Shaw, C. A.

“…The factors responsible for ALS‐parkinsonism dementia complex (ALS‐PDC), the unique neurological disorder of Guam, remain unresolved, but identification of…”
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Neurotrophins Stimulate Phosphorylation of Synapsin I by MAP Kinase and Regulate Synapsin I-Actin Interactions by Jovanovic, Jasmina N., Benfenati, Fabio, Siow, Law L., Sihra, Talvinder S., Sanghera, Jasbinder S., Pelech, Steven L., Greengard, Paul, Czernik, Andrew J.

“…The ability of neurotrophins to modulate the survival and differentiation of neuronal populations involves the Trk/MAP (mitogen-activated protein kinase)…”
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MAP Kinases: Charting the Regulatory Pathways by Pelech, Steven L., Sanghera, Jasbinder S.

“…One of the major mitogenic signaling routes involved in the mediation of intracellular transmission of growth factor signals by sequentially activated protein…”
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Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages by WEINSTEIN, S. L, SANGHERA, J. S, LEMKE, K, DEFRANCO, A. L, PELECH, S. L

“…Bacterial lipopolysaccharide (LPS) is a potent activator of antibacterial responses by macrophages. Following LPS stimulation, the tyrosine phosphorylation of…”
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Differential activation of the ERK, JNK, and p38 mitogen-activated protein kinases by CD40 and the B cell antigen receptor by Sutherland, CL, Heath, AW, Pelech, SL, Young, PR, Gold, MR

“…B cell antigen receptor (BCR)-induced apoptosis in the WEHI-231 B lymphoma cell line can be prevented by engaging CD40. We have used this cell line to…”
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Definition of a consensus sequence for peptide substrate recognition by p44mpk, the meiosis-activated myelin basic protein kinase by Clark-Lewis, I., Sanghera, J.S., Pelech, S.L.

“…Synthetic peptides have been used to define the consensus amino acid sequence for substrate recognition by the meiosis-activated myelin basic protein (MBP)…”
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Modulation of NMDA‐mediated excitotoxicity by protein kinase C by Wagey, R., Hu, J., Pelech, S. L., Raymond, L. A., Krieger, C.

“…Excessive activation of N‐methyl‐d‐aspartate (NMDA) receptors leads to cell death in human embryonic kidney‐293 (HEK) cells which have been transfected with…”
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Activation of multiple proline-directed kinases by bacterial lipopolysaccharide in murine macrophages by Sanghera, JS, Weinstein, SL, Aluwalia, M, Girn, J, Pelech, SL

“…Bacterial LPS stimulation of murine macrophages leads to increased tyrosine phosphorylation and activation of the 42- and 44-kDa mitogen-activated protein…”
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Activation of p42 mitogen-activated protein kinase by glutamate receptor stimulation in rat primary cortical cultures by Fiore, R S, Murphy, T H, Sanghera, J S, Pelech, S L, Baraban, J M

“…Recent studies have identified at least two homologous mitogen-activated protein (MAP) kinases that are activated by phosphorylation of both tyrosine and…”
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Phosphatidylinositol 3‐Kinase: Increased Activity and Protein Level in Amyotrophic Lateral Sclerosis by Wagey, R., Pelech, S. L., Duronio, V., Krieger, C.

“…: Enzyme activities and protein levels of several protein and lipid kinases were measured in postmortem tissue from patients who died with amyotrophic lateral…”
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p42 mitogen-activated protein kinase in brain: prominent localization in neuronal cell bodies and dendrites by Fiore, R S, Bayer, V E, Pelech, S L, Posada, J, Cooper, J A, Baraban, J M

“…Neurotransmitters and growth factors can trigger activation of a newly described family of mitogen-activated protein kinases. To help define the role of this…”
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Granulocyte-Macrophage Colony-Stimulating Factor, Interleukin-3, and Steel Factor Induce Rapid Tyrosine Phosphorylation of p42 and p44 MAP Kinase by Okuda, Keiko, Sanghera, Jasbinder S., Pelech, Steven L., Kanakura, Yuzuru, Hallek, Michael, Griffin, James D., Druker, Brian J.

“…Granulocyte-macrophage colony-stimulating factor (GM-CSF), lnterleukin-3 (IL-3), and Steel Factor (SF) induce proliferation of hematopoietic cells through…”
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Phosphorylation and Regulation of the Na+/H+ Exchanger through Mitogen-Activated Protein Kinase by Wang, H, Silva, N. L. C. L, Lucchesi, P. A, Haworth, R, Wang, K, Michalak, M, Pelech, S, Fliegel, L

“…We examined mitogen-activated protein kinase-mediated phosphorylation and activation of the Na+/H+ exchanger isoform type 1. A rabbit skeletal muscle extract…”
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Phosphatidylinositol 3-kinase activity in murine motoneuron disease: the progressive motor neuropathy mouse by Wagey, R, Lurot, S, Perrelet, D, Pelech, S.L, Sagot, Y, Krieger, C

“…A murine model of motoneuron disease, the pmn/pmn mouse, shows a reduction in the retrograde transport of fluorescent probes applied directly onto the cut end…”
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