Search Results - "Pel, Joel"

Duplex Proximity Sequencing (Pro-Seq): A method to improve DNA sequencing accuracy without the cost of molecular barcoding redundancy by Pel, Joel, Choi, Wendy W Y, Leung, Amy, Shibahara, Gosuke, Gelinas, Laura, Despotovic, Milenko, Ung, W Lloyd, Marziali, Andre

“…A challenge in the clinical adoption of cell-free DNA (cfDNA) liquid biopsies for cancer care is their high cost compared to potential reimbursement. The most…”
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Rapid and highly-specific generation of targeted DNA sequencing libraries enabled by linking capture probes with universal primers by Pel, Joel, Leung, Amy, Choi, Wendy W Y, Despotovic, Milenko, Ung, W Lloyd, Shibahara, Gosuke, Gelinas, Laura, Marziali, Andre

“…Targeted Next Generation Sequencing (NGS) is being adopted increasingly broadly in many research, commercial and clinical settings. Currently used target…”
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Winnowing DNA for rare sequences: highly specific sequence and methylation based enrichment by Thompson, Jason D, Shibahara, Gosuke, Rajan, Sweta, Pel, Joel, Marziali, Andre

“…Rare mutations in cell populations are known to be hallmarks of many diseases and cancers. Similarly, differential DNA methylation patterns arise in rare cell…”
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Nonlinear Electrophoretic Response Yields a Unique Parameter for Separation of Biomolecules by Pel, Joel, Broemeling, David, Mai, Laura, Poon, Hau-Ling, Tropini, Giorgia, Warten, René L., Holt, Robert A., Marziali, Andre, Davis, Ronald W.

“…We demonstrate a unique parameter for biomolecule séparation that results from the nonlinear response of long, chargea polymers to electrophoretic fields and…”
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Efficient genomic DNA extraction from low target concentration bacterial cultures using SCODA DNA extraction technology by So, Austin, Pel, Joel, Rajan, Sweta, Marziali, Andre

“…Methods for the extraction of nucleic acids are straightforward in instances where there is ample nucleic acid mass in the sample and contamination is minimal…”
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Abstract 425: Linked Target Capture: Rapid and high-performance NGS target enrichment for clinical sequencing applications by Pel, Joel, Choi, Wendy, Despotovic, Milenko, Gelinas, Laura, Leung, Amy, Ung, Lloyd, Marziali, Andre

“…With the continued decrease of DNA sequencing costs, targeted next-generation sequencing (NGS) is seeing broad adoption in many research, commercial and…”
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Duplex Proximity Sequencing by Pel, Joel, Choi, Wendy W. Y, Leung, Amy, Shibahara, Gosuke, Gelinas, Laura, Despotovic, Milenko, Ung, W. Lloyd, Marziali, Andre

“…A challenge in the clinical adoption of cell-free DNA (cfDNA) liquid biopsies for cancer care is their high cost compared to potential reimbursement. The most…”
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DNA Target Enrichment and Background Depletion for Detection of Rare Sequences by Pel, Joel, Wiggin, Matthew, Marziali, Andre

“…We present an electrophoretic sample preparation method that is capable of both enriching a sample for multiple rare sequence targets from a large wild-type…”
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Highly Multiplexed Profiling of Low Abundance Tumor Mutations in Plasma by Wiggin, Matthew, Pel, Joel, Vysotskaia, Valentina, Broemeling, David, Marziali, Andre, Hanson, Dan

“…We have demonstrated a novel somatic mutation enrichment methodology demonstrating multiplexed detection of tumor mutations in plasma with sensitivity as low…”
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Novel electrophoresis mechanism based on synchronous alternating drag perturbation by Marziali, Andre, Pel, Joel, Bizzotto, Dan, Whitehead, Lorne A.

“…We present a novel means of transporting molecules in solution by applying a zero‐time‐average alternating motive force to the molecules, and perturbing the…”
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An Instrument for Automated Purification of Nucleic Acids from Contaminated Forensic Samples by Broemeling, David J., Pel, Joel, Gunn, Dylan C., Mai, Laura, Thompson, Jason D., Poon, Hiron, Marziali, Andre

“…Forensic crime scene sample analysis, by its nature, often deals with samples in which there are low amounts of nucleic acids, on substrates that often lead to…”
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