Search Results - "Peixoto, Christophe"

Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis by Desroy, Nicolas, Housseman, Christopher, Bock, Xavier, Joncour, Agnès, Bienvenu, Natacha, Cherel, Laëtitia, Labeguere, Virginie, Rondet, Emilie, Peixoto, Christophe, Grassot, Jean-Marie, Picolet, Olivier, Annoot, Denis, Triballeau, Nicolas, Monjardet, Alain, Wakselman, Emanuelle, Roncoroni, Veronique, Le Tallec, Sandrine, Blanque, Roland, Cottereaux, Celine, Vandervoort, Nele, Christophe, Thierry, Mollat, Patrick, Lamers, Marieke, Auberval, Marielle, Hrvacic, Boska, Ralic, Jovica, Oste, Line, van der Aar, Ellen, Brys, Reginald, Heckmann, Bertrand

“…Autotaxin is a circulating enzyme with a major role in the production of lysophosphatic acid (LPA) species in blood. A role for the autotaxin/LPA axis has been…”
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Discovery of Diarylhydantoins as New Selective Androgen Receptor Modulators by Nique, François, Hebbe, Séverine, Peixoto, Christophe, Annoot, Denis, Lefrançois, Jean-Michel, Duval, Eric, Michoux, Laurence, Triballeau, Nicolas, Lemoullec, Jean-Michel, Mollat, Patrick, Thauvin, Maxime, Prangé, Thierry, Minet, Dominique, Clément-Lacroix, Philippe, Robin-Jagerschmidt, Catherine, Fleury, Damien, Guédin, Denis, Deprez, Pierre

“…A novel selective androgen receptor modulator scaffold has been discovered through structural modifications of hydantoin antiandrogens. Several…”
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Identification of a 4‑(Hydroxymethyl)diarylhydantoin as a Selective Androgen Receptor Modulator by Nique, François, Hebbe, Séverine, Triballeau, Nicolas, Peixoto, Christophe, Lefrançois, Jean-Michel, Jary, Hélène, Alvey, Luke, Manioc, Murielle, Housseman, Christopher, Klaassen, Hugo, Van Beeck, Kris, Guédin, Denis, Namour, Florence, Minet, Dominque, Van der Aar, Ellen, Feyen, Jean, Fletcher, Stephen, Blanqué, Roland, Robin-Jagerschmidt, Catherine, Deprez, Pierre

“…Structural modification performed on a 4-methyl-4-(4-hydroxyphenyl)hydantoin series is described which resulted in the development of a new series of…”
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Discovery of GLPG1972/S201086, a Potent, Selective, and Orally Bioavailable ADAMTS‑5 Inhibitor for the Treatment of Osteoarthritis by Brebion, Franck, Gosmini, Romain, Deprez, Pierre, Varin, Marie, Peixoto, Christophe, Alvey, Luke, Jary, Hélène, Bienvenu, Natacha, Triballeau, Nicolas, Blanque, Roland, Cottereaux, Céline, Christophe, Thierry, Vandervoort, Nele, Mollat, Patrick, Touitou, Robert, Leonard, Philip, Ceuninck, Frédéric De, Botez, Iuliana, Monjardet, Alain, van der Aar, Ellen, Amantini, David

“…There are currently no approved disease-modifying osteoarthritis (OA) drugs (DMOADs). The aggrecanase ADAMTS-5 is key in the degradation of human aggrecan…”
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Optimization of Selectivity and Pharmacokinetic Properties of Salt‑Inducible Kinase Inhibitors that Led to the Discovery of Pan-SIK Inhibitor GLPG3312 by Temal-Laib, Taouès, Peixoto, Christophe, Desroy, Nicolas, De Lemos, Elsa, Bonnaterre, Florence, Bienvenu, Natacha, Picolet, Olivier, Sartori, Eric, Bucher, Denis, López-Ramos, Miriam, Roca Magadán, Carlos, Laenen, Wendy, Flower, Thomas, Mollat, Patrick, Bugaud, Olivier, Touitou, Robert, Pereira Fernandes, Anna, Lavazais, Stephanie, Monjardet, Alain, Borgonovi, Monica, Gosmini, Romain, Brys, Reginald, Amantini, David, De Vos, Steve, Andrews, Martin

“…Salt-inducible kinases (SIKs) SIK1, SIK2, and SIK3 are serine/threonine kinases and form a subfamily of the protein kinase AMP-activated protein kinase (AMPK)…”
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Discovery of Clinical Candidate GLPG3970: A Potent and Selective Dual SIK2/SIK3 Inhibitor for the Treatment of Autoimmune and Inflammatory Diseases by Peixoto, Christophe, Joncour, Agnes, Temal-Laib, Taouès, Tirera, Amynata, Dos Santos, Aurélie, Jary, Hélène, Bucher, Denis, Laenen, Wendy, Pereira Fernandes, Anna, Lavazais, Stephanie, Delachaume, Carole, Merciris, Didier, Saccomani, Corinne, Drennan, Michael, López-Ramos, Miriam, Wakselman, Emanuelle, Dupont, Sonia, Borgonovi, Monica, Roca Magadan, Carlos, Monjardet, Alain, Brys, Reginald, De Vos, Steve, Andrews, Martin, Jimenez, Juan-Miguel, Amantini, David, Desroy, Nicolas

“…The salt-inducible kinases (SIKs) SIK1, SIK2, and SIK3 belong to the adenosine monophosphate-activated protein kinase (AMPK) family of serine/threonine…”
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Discovery, Structure–Activity Relationship, and Binding Mode of an Imidazo[1,2‑a]pyridine Series of Autotaxin Inhibitors by Joncour, Agnès, Desroy, Nicolas, Housseman, Christopher, Bock, Xavier, Bienvenu, Natacha, Cherel, Laëtitia, Labeguere, Virginie, Peixoto, Christophe, Annoot, Denis, Lepissier, Luce, Heiermann, Jörg, Hengeveld, Willem Jan, Pilzak, Gregor, Monjardet, Alain, Wakselman, Emanuelle, Roncoroni, Veronique, Le Tallec, Sandrine, Galien, René, David, Christelle, Vandervoort, Nele, Christophe, Thierry, Conrath, Katja, Jans, Mia, Wohlkonig, Alexandre, Soror, Sameh, Steyaert, Jan, Touitou, Robert, Fleury, Damien, Vercheval, Lionel, Mollat, Patrick, Triballeau, Nicolas, van der Aar, Ellen, Brys, Reginald, Heckmann, Bertrand

“…Autotaxin (ATX) is a secreted enzyme playing a major role in the production of lysophosphatidic acid (LPA) in blood through hydrolysis of lysophosphatidyl…”
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Correction to Discovery, Structure–Activity Relationship, and Binding Mode of an Imidazo[1,2‑a]pyridine Series of Autotaxin Inhibitors by Joncour, Agnès, Desroy, Nicolas, Housseman, Christopher, Bock, Xavier, Bienvenu, Natacha, Cherel, Laëtitia, Labeguere, Virginie, Peixoto, Christophe, Annoot, Denis, Lepissier, Luce, Heiermann, Jörg, Hengeveld, Willem Jan, Pilzak, Gregor, Monjardet, Alain, Wakselman, Emanuelle, Roncoroni, Veronique, Le Tallec, Sandrine, Galien, René, David, Christelle, Vandervoort, Nele, Christophe, Thierry, Conrath, Katja, Jans, Mia, Wohlkonig, Alexandre, Soror, Sameh, Steyaert, Jan, Touitou, Robert, Fleury, Damien, Vercheval, Lionel, Mollat, Patrick, Triballeau, Nicolas, van der Aar, Ellen, Brys, Reginald, Heckmann, Bertrand

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A Quality Model for Spreadsheets by Cunha, J., Fernandes, J. P., Peixoto, C., Saraiva, J.

“…In this paper we present a quality model for spreadsheets based on the ISO/IEC 9126 standard that defines a generic quality model for software. To each of the…”
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Quality Model for Spreadsheets: Design and Implementation by Peixoto, Christophe Campos

“…There is a huge number of Spreadsheets developed by end-user programmers, and this number is continually increasing. Since those End-user programmers often…”
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Discovery of 2‑[[2-Ethyl-6-[4-[2-(3-hydroxy­azetidin-1-yl)-2-oxoethyl]­piperazin-1-yl]-8-methyl­imidazo[1,2‑a]pyridin-3-yl]­methylamino]-4-(4-fluorophenyl)­thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis by Desroy, Nicolas, Housseman, Christopher, Bock, Xavier, Joncour, Agnès, Bienvenu, Natacha, Cherel, Laëtitia, Labeguere, Virginie, Rondet, Emilie, Peixoto, Christophe, Grassot, Jean-Marie, Picolet, Olivier, Annoot, Denis, Triballeau, Nicolas, Monjardet, Alain, Wakselman, Emanuelle, Roncoroni, Veronique, Le Tallec, Sandrine, Blanque, Roland, Cottereaux, Celine, Vandervoort, Nele, Christophe, Thierry, Mollat, Patrick, Lamers, Marieke, Auberval, Marielle, Hrvacic, Boska, Ralic, Jovica, Oste, Line, van der Aar, Ellen, Brys, Reginald, Heckmann, Bertrand

“…Autotaxin is a circulating enzyme with a major role in the production of lysophosphatic acid (LPA) species in blood. A role for the autotaxin/LPA axis has been…”
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Synthesis of isothiochroman 2,2-dioxide and 1,2-benzooxathiin 2,2-dioxide gyrase B inhibitors by Peixoto, Christophe, Laurin, Patrick, Klich, Michel, Dupuis-Hamelin, Claudine, Mauvais, Pascale, Lassaigne, Patrice, Bonnefoy, Alain, Musicki, Branislav

“…The design, synthesis and in vitro biological evaluation of isothiochroman 2,2-dioxide and 1,2-benzooxathiin 2,2-dioxide analogues of coumarin inhibitors of…”
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