Search Results - "Peishoff, C E"

Investigation of conformational specificity at GPIIb/IIIa: evaluation of conformationally constrained RGD peptides by Peishoff, Catherine E, Ali, Fadia E, Bean, John W, Calvo, Raul, D'Ambrosio, Cynthia A, Eggleston, Drake S, Kline, Tammy Page, Koster, Paul F, Hwang, S. M

“…RGD-containing proteins and peptides are known to bind to the platelet GPIIb/IIIa receptor and inhibit platelet aggregation. That a conformational component to…”
Get full text

Tyr-129 is Important to the Peptide Ligand Affinity and Selectivity of Human Endothelin Type A Receptor by Lee, Jonathan A., Elliott, John D., Sutiphong, Joyce A., Friesen, Westley J., Ohlstein, Eliot H., Stadel, Jeffrey M., Gleason, John G., Peishoff, Catherine E.

“…Molecular modeling and protein engineering techniques have been used to study residues within G-proteincoupled receptors that are potentially important to…”
Get full text

Conformational mobility in cyclic oligopeptides by Kopple, K D, Bean, J W, Bhandary, K K, Briand, J, D'Ambrosio, C A, Peishoff, C E

“…Analysis of two isomeric cyclic hexapeptides of composition (Asp, Arg, Gly2, Pro, D-Pro) by a nuclear Overhauser effect constrained distance geometry…”
Get more information

Conformations of cyclic pentapeptide endothelin receptor antagonists by Bean, J W, Peishoff, C E, Kopple, K D

“…The solution conformations in methanol and chloroform of the endothelin A receptor antagonists cyclo(dV-L-dW-dD-P), 1, and cyclo(dV-N alpha-MeL-dW-dD-P), 2,…”
Get more information

Slow binding inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase by Louis-Flamberg, Pearl, Peishoff, Catherine E, Bryan, Deborah L, Leber, Jack, Elliott, John D, Metcalf, Brian W, Mayer, Ruth J

“…The mechanism of slow binding inhibition of 3-hydroxy-3-methylglutaryl- coenzyme A reductase by lovastatin, fluindostatin, and related compounds was studied…”
Get full text

Conformational analysis of cyclic hexapeptides containing the D-Pro-L-Pro sequence to fix .beta.-turn positions by Bean, John W, Kopple, Kenneth D, Peishoff, Catherine E

Get full text

Design and synthesis of a C7 mimetic for the predicted .gamma.-turn conformation found in several constrained RGD antagonists by Callahan, James F, Bean, John W, Burgess, Joelle L, Eggleston, Drake S, Hwang, Shing Mei, Kopple, Kenneth D, Koster, Paul F, Nichols, Andrew, Peishoff, Catherine E

Get full text

Conformations of Arg-Gly-Asp containing heterodetic cyclic peptides: solution and crystal studies by Kopple, Kenneth D, Baures, Paul W, Bean, John W, D'Ambrosio, Cynthia A, Hughes, John L, Peishoff, Catherine E, Eggleston, Drake S

Get full text

Potent non-peptide fibrinogen receptor antagonists which present an alternative pharmacophore by Ku, Thomas W, Miller, William H, Bondinell, William E, Erhard, Karl F, Keenan, Richard M, Nichols, Andrew J, Peishoff, Catherine E, Samanen, James M, Wong, Angela S, Huffman, William F

Get full text

Metal mediated protease inhibition: design and synthesis of inhibitors of the human cytomegalovirus (hCMV) protease by Dhanak, Dashyant, Burton, George, Christmann, Lisa T, Darcy, Michael G, Elrod, Kyle C, Kaura, Arun, Keenan, Richard M, Link, John O, Peishoff, Catherine E, Shah, Dinubhai H

“…A versatile synthetic route to a novel series of bis-imidazolemethanes designed to inhibit the hCMV protease has been developed and a series of potential metal…”
Get full text

Endothelin receptor antagonists by Elliott, J D, Ohlstein, E H, Peishoff, C E, Ellens, H M, Lago, M A

Get more information

Potent nonpeptide angiotensin II receptor antagonists. 2. 1-(Carboxybenzyl)imidazole-5-acrylic acids by Keenan, Richard M, Weinstock, Joseph, Finkelstein, Joseph A, Franz, Robert G, Gaitanopoulos, Dimitri E, Girard, Gerald R, Hill, David T, Morgan, Tina M, Samanen, James M

“…The further evolution of the imidazole-5-acrylic acid series of nonpeptide angiotensin II receptor antagonists is detailed (for Part 1, see: J. Med. Chem…”
Get full text

Discovery of Potent Nonpeptide Vitronectin Receptor (αVβ3) Antagonists by Keenan, Richard M, Miller, William H, Kwon, Chet, Ali, Fadia E, Callahan, James F, Calvo, Raul R, Hwang, Shing-Mei, Kopple, Kenneth D, Peishoff, Catherine E, Samanen, James M, Wong, Angela S, Yuan, Chuan-Kui, Huffman, William F

Get full text

Comparison of the structures of the endothelin A receptor antagonists BQ123 and N-methyl leucine BQ123 with the crystal structure of the C-terminal tail of endothelin-1 by Peishoff, Catherine E., Janes, Robert W., Wallace, B.A.

“…The functionally important regions of the cyclic pentapeptide endothelin A receptor antagonist BQ123 are shown to correlate with the structure of the…”
Get full text

Conformations of cyclic heptapeptides: crystal structure and computational studies of evolidine by Eggleston, Drake S, Baures, Paul W, Peishoff, Catherine E, Kopple, Kenneth D

Get full text

Conformation of a cyclic heptapeptide in solution: an NMR constrained distance geometry search procedure by Peishoff, Catherine E, Bean, John W, Kopple, Kenneth D

Get full text

Design and evaluation of small peptides mapping the exposed surface of IL-8 by Thompson, S K, Veber, D F, Jurewicz, A J, Peishoff, C E, Lee, J M, White, J R

“…In an effort to determine which regions of IL-8 are involved in interactions with its receptors, eight peptides were designed to correspond to distinct exposed…”
Get more information

1,3-Diarylindan-2-carboxylic Acids, Potent and Selective Non-Peptide Endothelin Receptor Antagonists by Elliott, John D, Lago, M. Amparo, Cousins, Russell D, Gao, Aiming, Leber, Jack D, Erhard, Karl F, Nambi, Ponnal, Elshourbagy, Nabil A, Kumar, Chandrika

Get full text

Potent, Selective, Orally Active 3-Oxo-1,4-benzodiazepine GPIIb/IIIa Integrin Antagonists by Samanen, James M, Ali, Fadia E, Barton, Linda S, Bondinell, William E, Burgess, Joelle L, Callahan, James F, Calvo, Raul R, Chen, Wenting, Chen, Lichong, Erhard, Karl, Feuerstein, Giora, Heys, Richard, Hwang, Shing-Mei, Jakas, Dalia R, Keenan, Richard M, Ku, Thomas W, Kwon, Chet, Lee, Chao-Pin, Miller, William H, Newlander, Kenneth A, Nichols, Andrew, Parker, Michael, Peishoff, Catherine E, Rhodes, Gerald, Ross, Steven, Shu, Arthur, Simpson, Richard, Takata, Dennis, Yellin, Tobias O, Uzsinskas, Irene, Venslavsky, Joseph W, Yuan, Chuan-Kui, Huffman, William F

Get full text

Direct design of a potent non-peptide fibrinogen receptor antagonist based on the structure and conformation of a highly constrained cyclic RGD peptide by Ku, Thomas W, Ali, Fadia E, Barton, Linda S, Bean, John W, Bondinell, William E, Burgess, Joelle L, Callahan, James F, Calvo, Raul R, Chen, Lichong

Get full text