Search Results - "Peirson, S. N."

Experimental validation of novel and conventional approaches to quantitative real‐time PCR data analysis by Peirson, Stuart N., Butler, Jason N., Foster, Russell G.

“…Real‐time PCR is being used increasingly as the method of choice for mRNA quantification, allowing rapid analysis of gene expression from low quantities of…”
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Signalling by melanopsin (OPN4) expressing photosensitive retinal ganglion cells by Hughes, S, Jagannath, A, Rodgers, J, Hankins, M W, Peirson, S N, Foster, R G

“…Over the past two decades there have been significant advances in our understanding of both the anatomy and function of the melanopsin system. It has become…”
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Sleep‐like behavior and 24‐h rhythm disruption in the Tc1 mouse model of Down syndrome by Heise, I., Fisher, S. P., Banks, G. T., Wells, S., Peirson, S. N., Foster, R. G., Nolan, P. M.

“…Down syndrome is a common disorder associated with intellectual disability in humans. Among a variety of severe health problems, patients with Down syndrome…”
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A lack of functional NK1 receptors explains most, but not all, abnormal behaviours of NK1R-/- mice(1) by Porter, A J, Pillidge, K, Tsai, Y C, Dudley, J A, Hunt, S P, Peirson, S N, Brown, L A, Stanford, S C

“…Mice lacking functional neurokinin-1 receptors (NK1R-/-) display abnormal behaviours seen in Attention Deficit Hyperactivity Disorder (hyperactivity,…”
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A lack of functional NK1 receptors explains most, but not all, abnormal behaviours of NK1R‐/‐ mice1 by Porter, A. J., Pillidge, K., Tsai, Y. C., Dudley, J. A., Hunt, S. P., Peirson, S. N., Brown, L. A., Stanford, S. C.

“…Mice lacking functional neurokinin‐1 receptors (NK1R‐/‐) display abnormal behaviours seen in Attention Deficit Hyperactivity Disorder (hyperactivity,…”
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Light-induced c-fos in melanopsin retinal ganglion cells of young and aged rodless/coneless (rd/rd cl) mice by Semo, Ma'ayan, Lupi, Daniela, Peirson, Stuart N., Butler, Jason N., Foster, Russell G.

“…Non‐rod, non‐cone ocular photoreceptors have been shown to mediate a range of irradiance detection tasks. The strongest candidates for these receptors are…”
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Melanopsin: an exciting photopigment by Hankins, Mark W, Peirson, Stuart N, Foster, Russell G

“…The discovery that mice lacking rods and cones are capable of regulating their circadian rhythms by light provided the conceptual framework for the discovery…”
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Nonuniform Distribution and Spectral Tuning of Photosensitive Retinal Ganglion Cells of the Mouse Retina by Hughes, Steven, Watson, Thomas S., Foster, Russell G., Peirson, Stuart N., Hankins, Mark W.

“…Melanopsin-expressing photosensitive retinal ganglion cells (pRGCs) represent a third class of retinal photoreceptor [1–3]. These cells are intrinsically…”
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Short-Wavelength Light Sensitivity of Circadian, Pupillary, and Visual Awareness in Humans Lacking an Outer Retina by Zaidi, Farhan H., Hull, Joseph T., Peirson, Stuart N., Wulff, Katharina, Aeschbach, Daniel, Gooley, Joshua J., Brainard, George C., Gregory-Evans, Kevin, Rizzo, Joseph F., Czeisler, Charles A., Foster, Russell G., Moseley, Merrick J., Lockley, Steven W.

“…As the ear has dual functions for audition and balance, the eye has a dual role in detecting light for a wide range of behavioral and physiological functions…”
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Expression of the candidate circadian photopigment melanopsin ( Opn4) in the mouse retinal pigment epithelium by Peirson, Stuart N., Bovee-Geurts, Petra H.M., Lupi, Daniela, Jeffery, Glen, DeGrip, Willem J., Foster, Russell G.

“…A number of responses to light, including circadian entrainment and pupillary constriction, are preserved in mammals that lack rod and cone photoreceptors…”
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Comparison of clock gene expression in SCN, retina, heart, and liver of mice by Peirson, Stuart N., Butler, Jason N., Duffield, Giles E., Takher, Sharanjit, Sharma, Puneet, Foster, Russell G.

“…In mammals, the suprachiasmatic nuclei (SCN) in the hypothalamus are the site of a central circadian pacemaker, regulating overt rhythms of behaviour and…”
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A lack of functional NK1 receptors explains most, but not all, abnormal behaviours of NK1R ‐/‐ mice 1 by Porter, A. J., Pillidge, K., Tsai, Y. C., Dudley, J. A., Hunt, S. P., Peirson, S. N., Brown, L. A., Stanford, S. C.

“…Abstract Mice lacking functional neurokinin‐1 receptors ( NK1R ‐/‐) display abnormal behaviours seen in Attention Deficit Hyperactivity Disorder…”
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Microarray Analysis and Functional Genomics Identify Novel Components of Melanopsin Signaling by Peirson, Stuart N., Oster, Henrik, Jones, Sarah L., Leitges, Michael, Hankins, Mark W., Foster, Russell G.

“…Within the mammalian retina, there exists a third photoreceptive system based upon a population of melanopsin (Opn4) expressing photosensitive retinal ganglion…”
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Disrupted Circadian Rhythms in a Mouse Model of Schizophrenia by Oliver, Peter L., Sobczyk, Melanie V., Maywood, Elizabeth S., Edwards, Benjamin, Lee, Sheena, Livieratos, Achilleas, Oster, Henrik, Butler, Rachel, Godinho, Sofia I.H., Wulff, Katharina, Peirson, Stuart N., Fisher, Simon P., Chesham, Johanna E., Smith, Janice W., Hastings, Michael H., Davies, Kay E., Foster, Russell G.

“…Sleep and circadian rhythm disruption has been widely observed in neuropsychiatric disorders including schizophrenia [1] and often precedes related symptoms…”
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Mammalian photoentrainment: results, methods, and approaches by Peirson, Stuart N, Thompson, Stewart, Hankins, Mark W, Foster, Russell G

“…Research on circadian biology over the past decade has paid increasing attention to the photoreceptor mechanisms that align the molecular clock to the 24-h…”
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Long-Term Constant Light Induces Constitutive Elevated Expression of mPER2 Protein in the Murine SCN: A Molecular Basis for Aschoff’s Rule? by Muñoz, Marta, Peirson, Stuart N., Hankins, Mark W., Foster, Russell G.

“…Circadian rhythms in behavior, metabolism, and physiology are based upon transcriptional/translational feedback loops involving a core set of clock genes that…”
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Multiple photopigments from the Mexican blind cavefish, Astyanax fasciatus: a microspectrophotometric study by Parry, Juliet W.L., Peirson, Stuart N., Wilkens, Horst, Bowmaker, James K.

“…The cave-dwelling (hypogean) form of the teleost Astyanax fasciatus is blind, having only subdermal eye rudiments, but nevertheless maintains intact opsin…”
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