Search Results - "Peinert, S"

Gene-modified T cells as immunotherapy for multiple myeloma and acute myeloid leukemia expressing the Lewis Y antigen by Peinert, S, Prince, H M, Guru, P M, Kershaw, M H, Smyth, M J, Trapani, J A, Gambell, P, Harrison, S, Scott, A M, Smyth, F E, Darcy, P K, Tainton, K, Neeson, P, Ritchie, D S, Hönemann, D

“…We have evaluated the carbohydrate antigen Lewis Y (Le Y ) as a potential target for T-cell immunotherapy of hematological neoplasias. Analysis of 81 primary…”
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Ex vivo culture of chimeric antigen receptor T cells generates functional CD8+ T cells with effector and central memory-like phenotype by Neeson, P, Shin, A, Tainton, K M, Guru, P, Prince, H M, Harrison, S J, Peinert, S, Smyth, M J, Trapani, J A, Kershaw, M H, Darcy, P K, Ritchie, D S

“…The anti-tumor efficacy of adoptively transferred T cells requires their in vivo persistence and memory polarization. It is unknown if human chimeric antigen…”
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Bortezomib added to high-dose melphalan as pre-transplant conditioning is safe in patients with heavily pre-treated multiple myeloma by Thompson, P A, Prince, H M, Seymour, J F, Ritchie, D, Stokes, K, Burbury, K, Wolf, M, Peinert, S, Joyce, T, Harrison, S J

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Absence of retroviral vector-mediated transformation of gene-modified T cells after long-term engraftment in mice by Westwood, J A, Murray, W K, Trivett, M, Shin, A, Neeson, P, MacGregor, D P, Haynes, N M, Trapani, J A, Mayura-Guru, P, Fox, S, Peinert, S, Honemann, D, Prince, H M, Ritchie, D, Scott, A M, Smyth, F E, Smyth, M J, Darcy, P K, Kershaw, M H

“…There is considerable concern regarding the transforming potential of retroviral vectors currently used for gene therapy, with evidence that retroviral…”
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Autologous peripheral blood T lymphocytes transduced with an anti lewisy chimeric receptor gene can be infused safely and persist in patients with lewisy positive acute myeloid leukaemia by Khot, A, Ritchie, D, Neeson, P, Peinert, S, Tai, T, Kravets, L, Chen, K, Hoenemann, D, Shin, M, Tainton, K, Westwood, J, Kershaw, M, Haurat, J, Trapani, J, Smyth, M, Darcy, P, Scott, A, Wall, D, Gambell, P, Dickinson, M, Westerman, D, Hicks, R, Prince, M

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Genetic modification of haematopoietic cells for combined resistance to podophyllotoxins, other agents covered by MDR1-mediated efflux activity and nitrosoureas by Baum, C, Peinert, S, Carpinteiro, A, Eckert, H G, Fairbairn, L J

“…Genetic transfer and expression of drug-resistance functions into haematopoietic stem and progenitor cells is a promising means to overcome both the acute and…”
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The Lewis-Y Carbohydrate Antigen is Expressed by Many Human Tumors and Can Serve as a Target for Genetically Redirected T cells Despite the Presence of Soluble Antigen in Serum by WESTWOOD, Jennifer A, MURRAY, William K, TRAPANI, Joseph A, PEINERT, Stefan, HÖNEMANN, Dirk, PRINCE, H. Miles, SCOTT, Andrew M, SMYTH, Mark J, DARCY, Phillip K, KERSHAW, Michael H, TRIVETT, Melanie, HAYNES, Nicole M, SOLOMON, Benjamin, MILESHKIN, Linda, BALL, David, MICHAEL, Michael, BURMAN, Angela, MAYURA-GURU, Preethi

“…In this study we aimed to determine the suitability of the Lewis-Y carbohydrate antigen as a target for immunotherapy using genetically redirected T cells…”
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Ex vivo culture of chimeric antigen receptor T cells generates functional [CD8.sup.+] T cells with effector and central memory-like phenotype by Neeson, P, Shin, A, Tainton, K.M, Guru, P, Prince, H.M, Harrison, S.J, Peinert, S, Smyth, M.J, Trapani, J.A, Kershaw, M.H, Darcy, P.K, Ritchie, D.S

“…The anti-tumor efficacy of adoptively transferred T cells requires their in vivo persistence and memory polarization. It is unknown if human chimeric antigen…”
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Ex vivo culture of chimeric antigen receptor T cells generates functional CD8 super(+) T cells with effector and central memory-like phenotype by Neeson, P, Shin, A, Tainton, K M, Guru, P, Prince, H M, Harrison, S J, Peinert, S, Smyth, M J, Trapani, J A, Kershaw, M H, Darcy, P K, Ritchie, D S

“…The anti-tumor efficacy of adoptively transferred T cells requires their in vivo persistence and memory polarization. It is unknown if human chimeric antigen…”
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BECAM: A salvage protocol with bevacizumab, capecitabin, and mitomycin C for patients with refractory metastatic colorectal cancer (CRC) or gastric cancer (GC) by Peinert, S., Arnold, D., Siewczynski, R., Kegel, T., Heider, C., Nietsch, H., Schmoll, H.

“…Abstract only 13554 Background: Bevacizumab (Bev), a monoclonal antibody targeted against VEGF, has shown to improve efficacy in CRC when combined with…”
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High Response Rates with the Combination of Bortezomib, Dexamethasone and the Pan-Histone Deacetylase Inhibitor Romidepsin in Patients with Relapsed or Refractory Multiple Myeloma in a Phase I/II Clinical Trial by Harrison, Simon James, Quach, Hang, Yuen, Kally, Strayer, Andrew, Copeman, Michael C., Peinert, S., Bishton, M., Wolf, M., Januszewicz, H., Kenealy, MK, Herbert, K., Westerman, David, Carney, D., Seymour, J. F, Johnstone, R. W, Ritchie, David, Prince, Miles

“…INTRODUCTION: Proteasome inhibitors (PI) and histone deacetylase inhibitors (HDACi) have demonstrated synergistic pre-clinical activity in multiple myeloma…”
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Cetuximab with oxaliplatin and capecitabine (CAPOX)in patients with metastatic colorectal cancer (mCRC) refractory to standard chemotherapy by Grothe, W., Arnold, D., Peinert, S., Voigt, W., Mantovani Loeffler, L., Siewczynski, R., Steps, G., Boehme, J., Graeven, U., Schmoll, H.-J.

“…Abstract only…”
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Weekly administration of 5-fluorouracil (5-FU), folinic acid (FA), oxaliplatin (L-OHP) and irinotecan (CPT-11) [FUFOXIRI] for patients with metastatic gastric or colorectal cancer by Harba, A., Peinert, S., Grothe, W., Jordan, K., Kegel, T., Mueller, L. P., Behrens, R., Grothey, A., Arnold, D., Schmoll, H.-J.

“…Abstract only…”
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Genetic protection of repopulating hematopoietic cells with an improved MDR1‐retrovirus allows administration of intensified chemotherapy following stem cell transplantation in mice by Carpinteiro, Alexander, Peinert, Stefan, Ostertag, Wolfram, Zander, Axel R., Hossfeld, Dieter K., Kühlcke, Klaus, Eckert, Hans‐Georg, Baum, Christopher, Hegewisch‐Becker, Susanna

“…This study was undertaken to analyze the hematotoxicity of paclitaxel (Taxol®) and to test whether transduction of repopulating hematopoietic cells with a…”
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