Search Results - "Peineau, Stephane"
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The JAK/STAT Pathway Is Involved in Synaptic Plasticity
Published in Neuron (Cambridge, Mass.) (26-01-2012)“…The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and…”
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Synaptoimmunology - roles in health and disease
Published in Molecular brain (20-06-2017)“…Mounting evidence suggests that the nervous and immune systems are intricately linked. Many proteins first identified in the immune system have since been…”
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Trans-Modulation of the Somatostatin Type 2A Receptor Trafficking by Insulin-Regulated Aminopeptidase Decreases Limbic Seizures
Published in The Journal of neuroscience (26-08-2015)“…Within the hippocampus, the major somatostatin (SRIF) receptor subtype, the sst2A receptor, is localized at postsynaptic sites of the principal neurons where…”
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Activation of microglial N-methyl-D-aspartate receptors triggers inflammation and neuronal cell death in the developing and mature brain
Published in Annals of neurology (01-10-2012)“…Objective: Activated microglia play a central role in the inflammatory and excitotoxic component of various acute and chronic neurological disorders. However,…”
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Synaptic plasticity modulation by circulating peptides and metaplasticity: Involvement in Alzheimer’s disease
Published in Pharmacological research (01-04-2018)“…[Display omitted] Synaptic plasticity is a cellular process involved in learning and memory whose alteration in its two main forms (Long Term Depression (LTD)…”
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Alzheimer’s disease: understanding homeostasis deregulation to foster development of effective therapies
Published in Pharmacological research (01-01-2019)Get full text
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7
Memory and plasticity impairment after binge drinking in adolescent rat hippocampus: GluN2A/GluN2B NMDA receptor subunits imbalance through HDAC2
Published in Addiction biology (01-05-2020)“…Ethanol (EtOH) induces cognitive impairment through modulation of synaptic plasticity notably in the hippocampus. The cellular mechanism(s) of these EtOH…”
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LTP Inhibits LTD in the Hippocampus via Regulation of GSK3β
Published in Neuron (Cambridge, Mass.) (01-03-2007)“…Glycogen synthase kinase-3 (GSK3) has been implicated in major neurological disorders, but its role in normal neuronal function is largely unknown. Here we…”
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Molecular mechanisms of somatostatin receptor trafficking
Published in Journal of molecular endocrinology (01-02-2012)“…The neuropeptide somatostatin (SRIF) is an important modulator of neurotransmission in the central nervous system and acts as a potent inhibitor of hormone and…”
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GluNs Detection and Functions in Microglial Cells
Published in Methods in molecular biology (Clifton, N.J.) (01-01-2017)“…Proving endogenous GluN presence and functions in microglia require complementary steps to demonstrate (1) that GluN genes are transcripted and translated, (2)…”
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Patch‐Clamp Recording of Low Frequency Stimulation‐induced Long‐Term Synaptic Depression in Rat Hippocampus Slices During Early and Late Neurodevelopment
Published in Alcoholism, clinical and experimental research (01-02-2021)“…Background Studying synaptic plasticity in the rat hippocampus slice is a well‐established way to analyze cellular mechanisms related to learning and memory…”
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Rabconnectin-3α is required for the morphological maturation of GnRH neurons and kisspeptin responsiveness
Published in Scientific reports (17-02-2017)“…A few hundred hypothalamic neurons form a complex network that controls reproduction in mammals by secreting gonadotropin-releasing hormone (GnRH). Timely…”
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A pivotal role of GSK-3 in synaptic plasticity
Published in Frontiers in molecular neuroscience (01-01-2012)“…Glycogen synthase kinase-3 (GSK-3) has many cellular functions. Recent evidence suggests that it plays a key role in certain types of synaptic plasticity, in…”
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Long-term depression in the CNS
Published in Nature reviews. Neuroscience (01-07-2010)“…Key Points Long-term depression (LTD) encompasses a family of synaptic plasticity mechanisms that can be triggered by the synaptic or pharmacological…”
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Conditional Induction of Math1 Specifies Embryonic Stem Cells to Cerebellar Granule Neuron Lineage and Promotes Differentiation into Mature Granule Neurons
Published in Stem cells (Dayton, Ohio) (01-04-2013)“…Directing differentiation of embryonic stem cells (ESCs) to specific neuronal subtype is critical for modeling disease pathology in vitro. An attractive means…”
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G protein-coupled receptor kinase 2 and group I metabotropic glutamate receptors mediate inflammation-induced sensitization to excitotoxic neurodegeneration
Published in Annals of neurology (01-05-2013)“…Objective The concept of inflammation‐induced sensitization is emerging in the field of perinatal brain injury, stroke, Alzheimer disease, and multiple…”
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The role of JAK-STAT signaling within the CNS
Published in JAK-STAT (01-01-2013)“…JAK-STAT is an efficient and highly regulated system mainly dedicated to the regulation of gene expression. Primarily identified as functioning in…”
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Inflammation processes in perinatal brain damage
Published in Journal of Neural Transmission (01-08-2010)“…Once viewed as an isolated, immune-privileged organ, the central nervous system has undergone a conceptual change. Neuroinflammation has moved into the focus…”
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Somatostatin Receptors Type 2 and 5 Expression and Localization During Human Pituitary Development
Published in Endocrinology (Philadelphia) (01-01-2014)“…Somatostatin (SRIF), by acting mainly through sst2 and sst5 receptors, is a potent inhibitor of hormonal secretion by the human anterior pituitary gland…”
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A systematic investigation of the protein kinases involved in NMDA receptor-dependent LTD: evidence for a role of GSK-3 but not other serine/threonine kinases
Published in Molecular brain (07-07-2009)“…The signalling mechanisms involved in the induction of N-methyl-D-aspartate (NMDA) receptor-dependent long-term depression (LTD) in the hippocampus are poorly…”
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