Search Results - "Pei, Jingqi"
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Mitochondria-affecting small molecules ameliorate proteostasis defects associated with neurodegenerative diseases
Published in Scientific reports (06-09-2021)“…Macroautophagic recycling of dysfunctional mitochondria, known as mitophagy, is essential for mitochondrial homeostasis and cell viability. Accumulation of…”
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Journal Article -
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The Metacaspase Gene PoMCA1 Enhances the Mycelial Heat Stress Tolerance and Regulates the Fruiting Body Development of Pleurotus ostreatus
Published in Horticulturae (01-02-2024)“…Pleurotus ostreatus is one of the most cultivated edible mushrooms worldwide, of which the fruiting body development is a highly complex process involving the…”
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Journal Article -
3
Mitochondrial metabolism as a target for acute myeloid leukemia treatment
Published in Cancer & metabolism (21-04-2021)“…Acute myeloid leukemias (AML) are a group of aggressive hematologic malignancies resulting from acquired genetic mutations in hematopoietic stem cells that…”
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Journal Article -
4
Utilizing Synergistic Potential of Mitochondria-Targeting Drugs for Leukemia Therapy
Published in Frontiers in oncology (03-04-2020)“…Acute myeloid leukemia (AML) is an aggressive group of cancers with high mortality rates and significant relapse risks. Current treatments are insufficient,…”
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Journal Article -
5
Single-Atom Fluorescence Switch: A General Approach toward Visible-Light-Activated Dyes for Biological Imaging
Published in Journal of the American Chemical Society (18-09-2019)“…Photoactivatable fluorophores afford powerful molecular tools to improve the spatial and temporal resolution of subcellular structures and dynamics. By…”
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Journal Article -
6
Polarization-Induced Temperature Self-Sensing and Self-Powering Behavior of Carbon-Carbon Composites
Published in IEEE sensors journal (01-07-2024)“…Pyropermittivity, pyroresistivity, and pyroelectret refer to the effect of temperature on permittivity, resistivity, and inherent electric field. They are…”
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Journal Article -
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The Metacaspase Gene IPoMCA/I1 Enhances the Mycelial Heat Stress Tolerance and Regulates the Fruiting Body Development of IPleurotus ostreatus/I
Published in Horticulturae (01-01-2024)“…Pleurotus ostreatus is one of the most cultivated edible mushrooms worldwide, of which the fruiting body development is a highly complex process involving the…”
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Journal Article -
8
Targeting Mitochondria Metabolisms for Novel AML Therapy Development
Published 01-01-2021“…Mitochondrial dysfunction contributes to a wide variety of pathologies, including neurodegenerative diseases, cancer, metabolic diseases, and aging. As a…”
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Dissertation -
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Addition of Isocyanide-Containing Amino Acids to the Genetic Code for Protein Labeling and Activation
Published in ACS chemical biology (20-12-2019)“…Site-specific introduction of bioorthogonal handles into biomolecules provides powerful tools for studying and manipulating the structures and functions of…”
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Journal Article -
10
Epichaperome inhibition targets TP53-mutant AML and AML stem/progenitor cells
Published in Blood (21-09-2023)“…•The HSP90 epichaperome is detected in TP53-mutant AML and AML stem/progenitor cells but not in healthy BM.•Targeting the epichaperome prevents outgrowth of…”
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Journal Article -
11
Novel mitochondria-targeting compounds selectively kill human leukemia cells
Published in Leukemia (01-08-2022)“…Acute myeloid leukemia (AML) is a heterogeneous group of aggressive hematological malignancies commonly associated with treatment resistance, high risk of…”
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Journal Article