Search Results - "Pei, Dong‐sheng"

System Xc−: a key regulatory target of ferroptosis in cancer by Liu, Man-ru, Zhu, Wen-tao, Pei, Dong-sheng

“…Summary Ferroptosis is a type of oxidative stress-dependent regulated necrosis characterized by excessive lipid peroxide accumulation. This novel cell death…”
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Serine hydroxymethyltransferase 2: a novel target for human cancer therapy by Xie, Min, Pei, Dong-Sheng

“…Summary Serine and glycine are the primary sources of one-carbon units that are vital for cell proliferation. Their abnormal metabolism is known to be…”
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Function and evolution of RNA N6-methyladenosine modification by Zhu, Zhi-Man, Huo, Fu-Chun, Pei, Dong-Sheng

“…N6-methyladenosine (m A) is identified as the most prevalent and abundant internal RNA modification, especially within eukaryotic mRNAs, which has attracted…”
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The biological function of IGF2BPs and their role in tumorigenesis by Du, Qiu-Ying, Zhu, Zhi-Man, Pei, Dong-Sheng

“…Summary The insulin-like growth factor-2 mRNA-binding proteins (IGF2BPs) pertain to a highly conservative RNA-binding family that works as a…”
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Friend or foe, the role of EGR-1 in cancer by Li, Tong-tong, Liu, Man-ru, Pei, Dong-sheng

“…Early growth response-1 (EGR-1), also termed NEFI-A and Krox-24, as a multi-domain protein is implicated in several vital physiological processes, including…”
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N6‐methyladenosine (m6A) RNA modification in human cancer by Huo, Fu‐Chun, Zhu, Zhi‐Man, Pei, Dong‐Sheng

“…N6‐methyladenosine (m6A) RNA modification, first discovered in 1974, is the most prevalent, abundant and penetrating messenger RNA (mRNA) modification in…”
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PAK5 promotes the migration and invasion of cervical cancer cells by phosphorylating SATB1 by Huo, Fu-Chun, Pan, Yao-Jie, Li, Tong-Tong, Mou, Jie, Pei, Dong-Sheng

“…p21-activated kinase 5 (PAK5) is involved in several oncogenic signaling pathways and its amplification or overexpression has been found in various types of…”
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SHMT2 promotes the tumorigenesis of renal cell carcinoma by regulating the m6A modification of PPAT by Huo, Fu-Chun, Xie, Min, Zhu, Zhi-Man, Zheng, Jun-Nian, Pei, Dong-Sheng

“…Serine hydroxymethyltransferase 2 (SHMT2) is the first rate-limiting enzyme for serine/glycine biosynthesis and one carbon metabolism. Here, we explore the…”
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Jab1 promotes gastric cancer tumorigenesis via non-ubiquitin proteasomal degradation of p14ARF by Wang, Lin, Du, Wen-Qi, Xie, Min, Liu, Man-Ru, Huo, Fu-Chun, Yang, Jing, Pei, Dong-Sheng

“…Background Jab1 has been reported to regulate various proteins in signal transduction pathways and be implicated in carcinogenesis or tumor progression…”
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MiR-106a-5p inhibits the cell migration and invasion of renal cell carcinoma through targeting PAK5 by Pan, Yao-Jie, Wei, Lu-Lu, Wu, Xiao-Jin, Huo, Fu-Chun, Mou, Jie, Pei, Dong-Sheng

“…MicroRNA-106a-5p (MiR-106a-5p), a small non-coding RNA, has been reported to be downregulated in astrocytoma, osteosarcoma and colorectal cancer. However, the…”
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Analysis of the association of HOTAIR single nucleotide polymorphism (rs920778) and risk of cervical cancer by Qiu, Haifeng, Liu, Qiuli, Li, Juan, Wang, Xiujuan, Wang, Yuan, Yuan, Zhongfu, Li, Jing, Pei, Dong-Sheng

“…We recently demonstrated that overexpression of HOTAIR (Hox transcript antisense intergenic RNA) was associated with tumor progression and radio‐resistance in…”
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NRP1 contributes to stemness and potentiates radioresistance via WTAP-mediated m6A methylation of Bcl-2 mRNA in breast cancer by Wang, Yang, Zhang, Lin, Sun, Xiao-Lin, Lu, Ya-Chun, Chen, Si, Pei, Dong-Sheng, Zhang, Lan-Sheng

“…NRP1 is a transmembrane glycoprotein that is highly expressed in a variety of tumors. There is evidence that NRP1 can enhance the stem cell properties of tumor…”
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Targeting the mitochondrial protein YME1L to inhibit osteosarcoma cell growth in vitro and in vivo by Sun, Xu, Shi, Ce, Dai, Jin, Zhang, Mei-Qing, Pei, Dong-Sheng, Yang, Lei

“…Exploring novel diagnostic and therapeutic biomarkers is extremely important for osteosarcoma. YME1 Like 1 ATPase (YME1L), locating in the mitochondrial inner…”
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HPV E7-drived ALKBH5 promotes cervical cancer progression by modulating m6A modification of PAK5 by Huo, Fu-Chun, Zhu, Zhi-Man, Du, Wen-Qi, Pan, Yao-Jie, Jiang, Xin, Kang, Meng-Jie, Liu, Bo-Wen, Mou, Jie, Pei, Dong-Sheng

“…Human papillomavirus (HPV) infection is a causative agent of cervical cancer (CC). N6-methyladenosine (m6A) modification is implicated in carcinogenesis and…”
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The role of high‐mobility group protein box 1 in lung cancer by Wu, Xiao‐Jin, Chen, Yuan‐Yuan, Gong, Chan‐Chan, Pei, Dong‐Sheng

“…High‐mobility group protein box 1(HMGB1)is a ubiquitous highly conserved nuclear protein. Acting as a chromatin‐binding factor, HMGB1 binds to DNA and plays an…”
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Long noncoding RNA MAPKAPK5-AS1 promotes colorectal cancer progression by cis-regulating the nearby gene MK5 and acting as a let-7f-1-3p sponge by Yang, Ting, Chen, Wei-Cong, Shi, Pei-Cong, Liu, Man-Ru, Jiang, Tao, Song, Hu, Wang, Jia-Qi, Fan, Rui-Zhi, Pei, Dong-Sheng, Song, Jun

“…Long noncoding RNAs (lncRNAs) are considered critical regulators in cancers; however, the clinical significance and mechanisms of MAPKAPK5-AS1 (hereinafter…”
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P53/microRNA-34-induced metabolic regulation: new opportunities in anticancer therapy by Zhang, Ding-Guo, Zheng, Jun-Nian, Pei, Dong-Sheng

“…MicroRNA-34 (miR-34) is directly regulated by p53, and its potential tumor suppressive roles have been studied extensively. As a p53-induced microRNA, miR-34…”
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MicroRNA-138-1-3p sensitizes sorafenib to hepatocellular carcinoma by targeting PAK5 mediated β-catenin/ABCB1 signaling pathway by Li, Tong-tong, Mou, Jie, Pan, Yao-jie, Huo, Fu-chun, Du, Wen-qi, Liang, Jia, Wang, Yang, Zhang, Lan-sheng, Pei, Dong-sheng

“…Abstract Background Sorafenib is a kinase inhibitor that is used as a first-line therapy in advanced hepatocellular carcinoma (HCC) patients. However, the…”
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The Emerging Role of CSN6 in Biological Behavior and Cancer Progress by Mao, Zun, Chen, Cheng, Pei, Dong-Sheng

“…The Constitutive Photomorphogenesis 9 (COP9) signalosome (CSN) subunit 6 (CSN6) noticeably acts as a regulator of the degradation of cancer-related proteins,…”
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PAK5-mediated phosphorylation and nuclear translocation of NF-κB-p65 promotes breast cancer cell proliferation in vitro and in vivo by Zhang, Ying-Chun, Huo, Fu-Chun, Wei, Lu-Lu, Gong, Chan-Chan, Pan, Yao-Jie, Mou, Jie, Pei, Dong-Sheng

“…Abnormal proliferation is significantly associated with the promotion of malignant tumor. Growing evidence suggest that the signal pathways of p21 -activated…”
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