Search Results - "Pehlke, Carolyn"

Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma by Conklin, Matthew W, Eickhoff, Jens C, Riching, Kristin M, Pehlke, Carolyn A, Eliceiri, Kevin W, Provenzano, Paolo P, Friedl, Andreas, Keely, Patricia J

“…Evidence for the potent influence of stromal organization and function on invasion and metastasis of breast tumors is ever growing. We have performed a…”
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Computational segmentation of collagen fibers from second-harmonic generation images of breast cancer by Bredfeldt, Jeremy S, Liu, Yuming, Pehlke, Carolyn A, Conklin, Matthew W, Szulczewski, Joseph M, Inman, David R, Keely, Patricia J, Nowak, Robert D, Mackie, Thomas R, Eliceiri, Kevin W

“…Second-harmonic generation (SHG) imaging can help reveal interactions between collagen fibers and cancer cells. Quantitative analysis of SHG images of collagen…”
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Understanding the impact of 2D and 3D fibroblast cultures on in vitro breast cancer models by Sung, Kyung Eun, Su, Xiaojing, Berthier, Erwin, Pehlke, Carolyn, Friedl, Andreas, Beebe, David J

“…The utilization of 3D, physiologically relevant in vitro cancer models to investigate complex interactions between tumor and stroma has been increasing. Prior…”
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Microtubules regulate GEF-H1 in response to extracellular matrix stiffness by Heck, Jessica N, Ponik, Suzanne M, Garcia-Mendoza, Maria G, Pehlke, Carolyn A, Inman, David R, Eliceiri, Kevin W, Keely, Patricia J

“…Breast epithelial cells sense the stiffness of the extracellular matrix through Rho-mediated contractility. In turn, matrix stiffness regulates RhoA activity…”
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Fibrillar Collagen Quantification With Curvelet Transform Based Computational Methods by Liu, Yuming, Keikhosravi, Adib, Pehlke, Carolyn A, Bredfeldt, Jeremy S, Dutson, Matthew, Liu, Haixiang, Mehta, Guneet S, Claus, Robert, Patel, Akhil J, Conklin, Matthew W, Inman, David R, Provenzano, Paolo P, Sifakis, Eftychios, Patel, Jignesh M, Eliceiri, Kevin W

“…Quantification of fibrillar collagen organization has given new insight into the possible role of collagen topology in many diseases and has also identified…”
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Control of 3-dimensional collagen matrix polymerization for reproducible human mammary fibroblast cell culture in microfluidic devices by Sung, Kyung Eun, Su, Gui, Pehlke, Carolyn, Trier, Steven M, Eliceiri, Kevin W, Keely, Patricia J, Friedl, Andreas, Beebe, David J

“…Abstract Interest in constructing a reliable 3-dimensional (3D) collagen culture platform in microfabricated systems is increasing as researchers strive to…”
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A new tool to quantify receptor recruitment to cell contact sites during host-pathogen interaction by Graus, Matthew S, Pehlke, Carolyn, Wester, Michael J, Davidson, Lisa B, Steinberg, Stanly L, Neumann, Aaron K

“…To understand the process of innate immune fungal recognition, we developed computational tools for the rigorous quantification and comparison of receptor…”
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A nondenatured, noncrosslinked collagen matrix to deliver stem cells to the heart by Kouris, Nicholas A, Squirrell, Jayne M, Jung, Jangwook P, Pehlke, Carolyn A, Hacker, Timothy, Eliceiri, Kevin W, Ogle, Brenda M

“…Stem cell transplantation holds promise as a therapeutic approach for the repair of damaged myocardial tissue. One challenge of this approach is efficient…”
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Super-resolution imaging of C-type lectin spatial rearrangement within the dendritic cell plasma membrane at fungal microbe contact sites by Itano, Michelle S, Graus, Matthew S, Pehlke, Carolyn, Wester, Michael J, Liu, Ping, Lidke, Keith A, Thompson, Nancy L, Jacobson, Ken, Neumann, Aaron K

“…Dendritic cells express DC-SIGN and CD206, C-type lectins (CTLs) that bind a variety of pathogens and may facilitate pathogen uptake for subsequent antigen…”
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3D Collagen Alignment Limits Protrusions to Enhance Breast Cancer Cell Persistence by Riching, Kristin M., Cox, Benjamin L., Salick, Max R., Pehlke, Carolyn, Riching, Andrew S., Ponik, Susan M., Bass, Benjamin R., Crone, Wendy C., Jiang, Yi, Weaver, Alissa M., Eliceiri, Kevin W., Keely, Patricia J.

“…Patients with mammographically dense breast tissue have a greatly increased risk of developing breast cancer. Dense breast tissue contains more stromal…”
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Transition to invasion in breast cancer: a microfluidic in vitro model enables examination of spatial and temporal effects by Sung, Kyung Eun, Yang, Ning, Pehlke, Carolyn, Keely, Patricia J, Eliceiri, Kevin W, Friedl, Andreas, Beebe, David J

“…The transition of ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC) is a critical step in breast cancer progression. We introduce a simple…”
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Optimal Aggregation of FcεRI with a Structurally Defined Trivalent Ligand Overrides Negative Regulation Driven by Phosphatases by Mahajan, Avanika, Barua, Dipak, Cutler, Patrick, Lidke, Diane S, Espinoza, Flor A, Pehlke, Carolyn, Grattan, Rachel, Kawakami, Yuko, Tung, Chang-Shung, Bradbury, Andrew R. M, Hlavacek, William S, Wilson, Bridget S

“…To investigate why responses of mast cells to antigen-induced IgE receptor (FcεRI) aggregation depend nonlinearly on antigen dose, we characterized a new…”
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Abstract B17: A microscale 3-D in vitro model of the breast cancer progression from DCIS to IDC: Deciphering the role of the stromal fibroblasts by Sung, Kyung Eun, Pehlke, Carolyn, Berthier, Erwin, Eliceiri, Kevin W., Friedl, Andreas, Beebe, David J.

“…Breast cancer progression from ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC) is a critical step in breast cancer. This invasive transition…”
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A New Tool to Quantify Receptor Recruitment to Cell Contact Sites during Host-Pathogen Interaction: e1003639 by Graus, Matthew S, Pehlke, Carolyn, Wester, Michael J, Davidson, Lisa B, Steinberg, Stanly L, Neumann, Aaron K

“…To understand the process of innate immune fungal recognition, we developed computational tools for the rigorous quantification and comparison of receptor…”
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Abstract A35: Aligned collagen is a prognostic signature for survival in human breast carcinoma by Conklin, Matthew W., Eickhoff, Jens, Riching, Kristin, Pehlke, Carolyn, Eliceiri, Kevin, Provenzano, Paolo, Friedl, Andreas, Keely, Patricia J.

“…Evidence for the potent influence of stromal organization and function on invasion and metastasis of breast tumors is ever growing. Here we have performed a…”
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Abstract 4749: Aligned collagen is a prognostic signature for survival in human breast carcinoma by Conklin, Matthew W., Eickoff, Jens C., Riching, Kristin M., Pehlke, Carolyn A., Eliceiri, Kevin W., Provenzano, Paolo P., Andreas, Friedl, Keely, Patricia J.

“…Evidence for the potent influence of stromal organization and function on invasion and metastasis of breast tumors is ever growing. Here we have performed a…”
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Quantitative analysis of disease-associated collagen I by Pehlke, Carolyn A

“…Collagen I density, distribution, and organization influence cell behavior and are potential biomarkers in a wide array of diseases ranging from osteogenesis…”
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Automation of Three-Dimensional Cell Culture in Arrayed Microfluidic Devices by Montanez-Sauri, Sara I., Sung, Kyung Eun, Puccinelli, John P., Pehlke, Carolyn, Beebe, David J.

“…The increasing interest in studying the interactions between cells and the extracellular matrix (ECM) has created a need for high throughput low-cost…”
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Quantitative analysis of disease-associated collagen I by Pehlke, Carolyn A

“…Collagen I density, distribution, and organization influence cell behavior and are potential biomarkers in a wide array of diseases ranging from osteogenesis…”
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Detecting cervical microstructure via ultrasound and optical microscopy by Reusch, Lisa M., Anderson, Janelle, Carlson, Lindsey C., Simmons, Heather A., Pehlke, Carolyn, Eliceiri, Kevin, Feltovich, Helen, Hall, Timothy J.

“…A novel method for characterizing the microstructural integrity of the human cervix is under development. The cervix is composed of mostly aligned collagen and…”
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