Search Results - "Peh, Hong Yong"

Oxidative and Nitrosative Stress and Histone Deacetylase-2 Activity in Exacerbations of COPD by Footitt, Joseph, PhD, Mallia, Patrick, PhD, Durham, Andrew L., PhD, Ho, W. Eugene, PhD, Trujillo-Torralbo, Maria-Belen, BSc, Telcian, Aurica G., PhD, Del Rosario, Ajerico, BSc, Chang, Cheng, PhD, Peh, Hong-Yong, MSc, Kebadze, Tatiana, MD, Aniscenko, Julia, Stanciu, Luminita, PhD, Essilfie-Quaye, Sarah, PhD, Ito, Kazuhiro, PhD, Barnes, Peter J., FCCP, Elkin, Sarah L., PhD, Kon, Onn M., MD, Wong, W. S. Fred, PhD, Adcock, Ian M., PhD, Johnston, Sebastian L., PhD

“…Background Respiratory virus infections are commonly associated with COPD exacerbations, but little is known about the mechanisms linking virus infection to…”
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Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1 by Kilic, Ayse, Halu, Arda, De Marzio, Margherita, Maiorino, Enrico, Duvall, Melody G, Bruggemann, Thayse Regina, Rojas Quintero, Joselyn J, Chase, Robert, Mirzakhani, Hooman, Sungur, Ayse Özge, Koepke, Janine, Nakano, Taiji, Peh, Hong Yong, Krishnamoorthy, Nandini, Abdulnour, Raja-Elie, Georgopoulos, Katia, Litonjua, Augusto A, Demay, Marie, Renz, Harald, Levy, Bruce D, Weiss, Scott T

“…Vitamin D possesses immunomodulatory functions and vitamin D deficiency has been associated with the rise in chronic inflammatory diseases, including asthma…”
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Molecular engineering of a therapeutic antibody for Blo t 5–induced allergic asthma by Chan, J.H. Sherlynn, BSc(Hons), Chua, Yen Leong, MSc, Peh, Hong Yong, BSc(Hons), Jovanovic, Vojislav, PhD, Gascoigne, Nicholas R.J., PhD, Wong, W. S. Fred, PhD, Chew, Fook Tim, PhD, Hanson, Brendon J., PhD, Kemeny, David M., PhD, FRCPath, MacAry, Paul A., PhD

“…Despite the coexistence of the 2 major dust mite species in the tropics and dual sensitization profiles in atopic individuals, IgE responses targeting Blomia…”
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Artemisinins: Pharmacological actions beyond anti-malarial by HO, Wanxing Eugene, HONG YONG PEH, TZE KHEE CHAN, WONG, W. S. Fred

“…Artemisinins are a family of sesquiterpene trioxane lactone anti-malarial agents originally derived from Artemisia annua L. The anti-malarial action of…”
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Immunopharmacology sessions at the 19th World Congress of Basic & Clinical Pharmacology 2023 by Peh, Hong Yong, Gurgone, Danila, Maffia, Pasquale

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Aeroallergens Induce Reactive Oxygen Species Production and DNA Damage and Dampen Antioxidant Responses in Bronchial Epithelial Cells by Chan, Tze Khee, Tan, W S Daniel, Peh, Hong Yong, Wong, W S Fred

“…Exposure to environmental allergens is a major risk factor for asthma development. Allergens possess proteolytic activity that is capable of disrupting the…”
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Granulocyte-targeted therapies for airway diseases by Tavares, Luciana P., Peh, Hong Yong, Tan, Wan Shun Daniel, Pahima, Hadas, Maffia, Pasquale, Tiligada, Ekaterini, Levi-Schaffer, Francesca

“…The average respiration rate for an adult is 12–20 breaths per minute, which constantly exposes the lungs to allergens and harmful particles. As a result,…”
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House dust mite–induced asthma causes oxidative damage and DNA double-strand breaks in the lungs by Chan, Tze Khee, BSc, Loh, Xin Yi, BSc, Peh, Hong Yong, BSc, Tan, W.N. Felicia, BSc, Tan, W.S. Daniel, BSc, Li, Na, PhD, Tay, Ian J.J., BEng, Wong, W.S. Fred, PhD, Engelward, Bevin P., ScD

“…Background Asthma is related to airway inflammation and oxidative stress. High levels of reactive oxygen and nitrogen species can induce cytotoxic DNA damage…”
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Resolvin D2 regulates type 2 inflammatory responses and promotes resolution of mouse allergic inflammation by Peh, Hong Yong, Brüggemann, Thayse R., Duvall, Melody G., Nshimiyimana, Robert, Nijmeh, Julie, Cinelli, Maria A., Israel, Elliot, Serhan, Charles N., Levy, Bruce D.

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Oligonucleotide Therapy for Obstructive and Restrictive Respiratory Diseases by Liao, Wupeng, Dong, Jinrui, Peh, Hong Yong, Tan, Lay Hong, Lim, Kah Suan, Li, Li, Wong, Wai-Shiu Fred

“…Inhaled oligonucleotide is an emerging therapeutic modality for various common respiratory diseases, including obstructive airway diseases like asthma and…”
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A disintegrin and metalloproteinase domain-15 deficiency leads to exaggerated cigarette smoke-induced chronic obstructive pulmonary disease (COPD)-like disease in mice by Wang, Xiaoyun, Rojas-Quintero, Joselyn, Zhang, Duo, Nakajima, Takahiro, Walker, Katherine H., Peh, Hong Yong, Li, Yuhong, Fucci, Quynh-Anh, Tesfaigzi, Yohannes, Owen, Caroline A.

“…A d isintegrin a nd m etalloproteinase domain-15 (ADAM15) is expressed by cells implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD),…”
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Ribosomal Protein S3 Gene Silencing Protects Against Cigarette Smoke-Induced Acute Lung Injury by Dong, Jinrui, Liao, Wupeng, Peh, Hong Yong, Tan, W.S. Daniel, Zhou, Shuo, Wong, W.S. Fred

“…Chronic obstructive pulmonary disease (COPD) is estimated to be the third leading cause of death by 2030. Transcription factor NF-κB may play a critical role…”
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Mouse phospholipid phosphatase 6 regulates dendritic cell cholesterol, macropinocytosis, and allergen sensitization by Brüggemann, Thayse R., Carlo, Troy, Krishnamoorthy, Nandini, Duvall, Melody G., Abdulnour, Raja-Elie E., Nijmeh, Julie, Peh, Hong Yong, Filippakis, Harilaos, Croze, Roxanne H., Goh, Byoungsook, Oh, Sungwhan F., Levy, Bruce D.

“…Lipid phosphate phosphatases are a family of enzymes with diverse cellular metabolic functions. Phospholipid phosphatase 6 (PLPP6) is a regulator of cellular…”
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Pro-resolving lipid mediators and therapeutic innovations in resolution of inflammation by Peh, Hong Yong, Chen, Jianmin

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Vitamin E therapy beyond cancer: Tocopherol versus tocotrienol by Peh, Hong Yong, Tan, W S Daniel, Liao, Wupeng, Wong, W S Fred

“…The discovery of vitamin E (α-tocopherol) began in 1922 as a vital component required in reproduction. Today, there are eight naturally occurring vitamin E…”
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Resolvin D2 Promotes the Resolution of Lung Inflammation in Allergen-Induced Asthma by Peh, Hong Yong, Bruggemann, Thayse R, Wong, WS Fred, Levy, Bruce D

“…Abstract Background: Asthma is a chronic inflammatory disease without complete resolution. The production of specialized pro-resolving mediators (SPMs) is…”
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15‐epi‐lipoxin A5 promotes neutrophil exit from exudates for clearance by splenic macrophages by Peh, Hong Yong, Nshimiyimana, Robert, Brüggemann, Thayse R., Duvall, Melody G., Nijmeh, Julie, Serhan, Charles N., Levy, Bruce D.

“…Specialized proresolving mediators (SPMs) promote local macrophage efferocytosis but excess leukocytes early in inflammation require additional leukocyte…”
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15-epi-lipoxin A 5 promotes neutrophil exit from exudates for clearance by splenic macrophages by Peh, Hong Yong, Nshimiyimana, Robert, Brüggemann, Thayse R, Duvall, Melody G, Nijmeh, Julie, Serhan, Charles N, Levy, Bruce D

“…Specialized proresolving mediators (SPMs) promote local macrophage efferocytosis but excess leukocytes early in inflammation require additional leukocyte…”
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ISM1 protects lung homeostasis via cell-surface GRP78-mediated alveolar macrophage apoptosis by Lam, Terence Y W, Nguyen, Ngan, Peh, Hong Yong, Shanmugasundaram, Mahalakshmi, Chandna, Ritu, Tee, Jong Huat, Ong, Chee Bing, Hossain, Md Zakir, Venugopal, Shruthi, Zhang, Tianyi, Xu, Simin, Qiu, Tao, Kong, Wan Ting, Chakarov, Svetoslav, Srivastava, Supriya, Liao, Wupeng, Kim, Jin-Soo, Teh, Ming, Ginhoux, Florent, Fred Wong, W S, Ge, Ruowen

“…Alveolar macrophages (AMs) are critical for lung immune defense and homeostasis. They are orchestrators of chronic obstructive pulmonary disease (COPD), with…”
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Andrographolide simultaneously augments Nrf2 antioxidant defense and facilitates autophagic flux blockade in cigarette smoke-exposed human bronchial epithelial cells by Tan, W.S. Daniel, Liao, Wupeng, Peh, Hong Yong, Vila, Merima, Dong, Jinrui, Shen, Han-Ming, Wong, W.S. Fred

“…Cigarette smoking is the leading cause of chronic obstructive pulmonary disease (COPD). Cigarette smoke heightens oxidative stress and impairs autophagy,…”
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