Search Results - "Peglion, Jean Louis"

Synthesis of Benzocyclobutenes by Palladium-Catalyzed C−H Activation of Methyl Groups: Method and Mechanistic Study by Chaumontet, Manon, Piccardi, Riccardo, Audic, Nicolas, Hitce, Julien, Peglion, Jean-Louis, Clot, Eric, Baudoin, Olivier

“…An efficient catalytic system has been developed for the synthesis of benzocyclobutenes by C−H activation of methyl groups. The optimal conditions employed a…”
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Characterization of the Annonaceous acetogenin, annonacinone, a natural product inhibitor of plasminogen activator inhibitor-1 by Pautus, Stéphane, Alami, Mouad, Adam, Fréderic, Bernadat, Guillaume, Lawrence, Daniel A., De Carvalho, Allan, Ferry, Gilles, Rupin, Alain, Hamze, Abdallah, Champy, Pierre, Bonneau, Natacha, Gloanec, Philippe, Peglion, Jean-Louis, Brion, Jean-Daniel, Bianchini, Elsa P., Borgel, Delphine

“…Plasminogen activator inhibitor-1 (PAI-1) is the main inhibitor of the tissue type and urokinase type plasminogen activators. High levels of PAI-1 are…”
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Synthetic efforts toward the synthesis of octalactins by Dinh, Minh-Thu, Bouzbouz, Samir, Péglion, Jean-Louis, Cossy, Janine

“…Octalactin B was synthesized from the commercially available methyl-3-butenoate and isobutyraldehyde, using enantioselective allyl- and crotyltitanations to…”
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The serotonin1A receptor partial agonist S15535 [4-(benzodioxan-5-yl)1-(indan-2-yl)piperazine] enhances cholinergic transmission and cognitive function in rodents: a combined neurochemical and behavioral analysis by Millan, Mark J, Gobert, Alain, Roux, Sylvain, Porsolt, Roger, Meneses, Alfredo, Carli, Mirjana, Di Cara, Benjamin, Jaffard, Robert, Rivet, Jean-Michel, Lestage, Pierre, Mocaer, Elisabeth, Peglion, Jean-Louis, Dekeyne, Anne

“…These studies examined the influence of the selective 5-hydroxytryptamine (serotonin) (5-HT)(1A) receptor partial agonist S15535…”
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In Vivo Quantification of Myocardial Dihydropyridine Binding Sites: A PET Study in Dogs by Valette, Heric, Dolle, Frederic, Guenther, Ilonka, Fuseau, Chantal, Coulon, Christine, Hinnen, Francoise, Peglion, Jean-Louis, Crouzel, Christian

“…Abnormalities in myocardial L-type Ca(2+) channel abundance and function have been described in cardiac hypertrophy and failure. In vivo quantification of the…”
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S33005, a novel ligand at both serotonin and norepinephrine transporters: I. Receptor binding, electrophysiological, and neurochemical profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine by Millan, M J, Gobert, A, Lejeune, F, Newman-Tancredi, A, Rivet, J M, Auclair, A, Peglion, J L

“…S33005 displayed marked affinity for native, rat, and cloned human serotonin (5-HT) transporters (SERT) and less pronounced affinity for norepinephrine (NE)…”
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Differential influence of selective 5-HT5A vs 5-HT1A , 5-HT1B , or 5-HT2C receptor blockade upon light-induced phase shifts in circadian activity rhythms: Interaction studies with citalopram by Gannon, Robert L, Peglion, Jean-Louis, Millan, Mark J

“…Abstract Though serotonergic mechanisms modulate circadian rhythms, roles of individual serotonin (5-HT) receptors remain uncertain since data are lacking for…”
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S33005, a novel ligand at both serotonin and norepinephrine transporters: II. Behavioral profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine by Millan, M J, Dekeyne, A, Papp, M, La Rochelle, C D, MacSweeny, C, Peglion, J L, Brocco, M

“…Reflecting its potent inhibition of serotonin (5-HT) reuptake (accompanying paper), S33005 blocked spontaneous tail-flicks induced by parachloroamphetamine in…”
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Anti-Ischemic Effects of Ivabradine, a Selective Heart Rate-Reducing Agent, in Exercise-Induced Myocardial Ischemia in Pigs by Vilaine, Jean-Paul, Bidouard, Jean-Pierre, Lesage, Ludovic, Reure, Hélène, Péglion, Jean-Louis

“…The effects of ivabradine, a novel heart rate-reducing agent that inhibits the cardiac pacemaker current If, were compared with those of the β-adrenergic…”
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Modulations of the amide function of the preferential dopamine D3 agonist (R,R)-S32504 : Improvements of affinity and selectivity for D3 versus D2 receptors by PEGLION, Jean-Louis, POITEVIN, Christophe, MANNOURY LA COUR, Clotilde, DUPUIS, Delphine, MILLAN, Mark J

“…Starting with the preferential dopamine (DA) D(3) agonist S32504, we prepared two series of derivatives of the general formula I-A and I-B, in an effort to…”
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Highly efficient synthesis of [11C]S12968 and [11C]S12967, for the in vivo imaging of the cardiac calcium channels using PET by Dolle, Frédéric, Valette, Héric, Hinnen, Françoise, Demphel, Stéphane, Bramoulle, Yann, Peglion, Jean-Louis, Crouzel, Christian

“…The dihydrophyridines S12968 ((−)‐S11568, absolute configuration S) and S12967 ((+)‐S11568, absolute configuration R), 3‐ethyl 5‐methyl…”
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5-HT2C receptors mediate penile erections in rats : actions of novel and selective agonists and antagonists by MILLAN, M. J, PEGLION, J.-L, LAVIELLE, G, PERRIN-MONNEYRON, S

“…The mixed 5-HT2A/5-HT2B/5-HT2C receptor agonist, m-(chlorophenyl)piperazine (mCPP), elicited penile erections in rats, an action mimicked by the selective…”
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Stereospecific in vitro and in vivo effects of the new sinus node inhibitor (+)-S 16257 by Thollon, Catherine, Bidouard, Jean-Pierre, Cambarrat, Christine, Lesage, Ludovic, Reure, Hélène, Delescluse, Isabelle, Vian, Joël, Peglion, Jean-Louis, Vilaine, Jean-Paul

“…The effects of the two isomers, (+)-S 16257 and (−)-S 16260, of a new bradycardic agent, (±)-S 15544 (7,8-dimethoxy 3-{3-{[(4,5-dimethoxybenzocyclobutan-1-yl)…”
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S32504, a novel naphtoxazine agonist at dopamine D3/D2 receptors: III. Actions in models of potential antidepressive and anxiolytic activity in comparison with ropinirole by Millan, Mark J, Brocco, Mauricette, Papp, Mariusz, Serres, Florence, La Rochelle, Christophe Drieu, Sharp, Trevor, Peglion, Jean-Louis, Dekeyne, Anne

“…In forced-swim tests in mice and rats, the novel D(3)/D(2) receptor agonist S32504…”
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Tetracyclic analogues of [+]-S 14297 : Synthesis and determination of affinity and selectivity at cloned human dopamine D3 vs D2 receptors by PEGLION, J.-L, VIAN, J, GOUMENT, B, DESPAUX, N, AUDINOT, V, MILLAN, M. J

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S32504, a novel naphtoxazine agonist at dopamine D3/D2 receptors: II. Actions in rodent, primate, and cellular models of antiparkinsonian activity in comparison to ropinirole by Millan, Mark J, Di Cara, Benjamin, Hill, Michael, Jackson, Michael, Joyce, Jeffrey N, Brotchie, Jonathan, McGuire, Steve, Crossman, Alan, Smith, Lance, Jenner, Peter, Gobert, Alain, Peglion, Jean-Louis, Brocco, Mauricette

“…These studies evaluated the potential antiparkinsonian properties of the novel dopamine D(3)/D(2) receptor agonist S32504 [(+)-trans-3,4,4a,5,6,…”
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S32504, a novel naphtoxazine agonist at dopamine D3/D2 receptors: I. Cellular, electrophysiological, and neurochemical profile in comparison with ropinirole by Millan, Mark J, Cussac, Didier, Gobert, Alain, Lejeune, Françoise, Rivet, Jean-Michel, Mannoury La Cour, Clotilde, Newman-Tancredi, Adrian, Peglion, Jean-Louis

“…S32504 [(+)-trans-3,4,4a,5,6,10b-hexahydro-9-carbamoyl-4-propyl-2H-naphth[1,2-b]-1,4-oxazine] displayed marked affinity for cloned, human (h)D(3) receptors…”
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Modulation of mesolimbic dopamine release by the selective dopamine D3 receptor antagonist, (+)-S 14297 by Rivet, J M, Audinot, V, Gobert, A, Peglion, J L, Millan, M J

“…In Chinese hamster ovary cells stably transfected with recombinant rat dopamine D2 or D3 receptors, the naphthofurane antagonist, (+)-S 14297…”
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Synthesis of spiro[quinoline-2,4′-piperidines] Heck versus radical reaction by Cossy, Janine, Poitevin, Christophe, Pardo, Domingo Gomez, Peglion, Jean-Louis, Dessinges, Aimée

“…The synthesis of spiro[quinoline-2,4′-piperidines] by using a radical or a Heck reaction, as the key step, is described. Allylamino or propargylamino…”
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S 14297, a novel selective ligand at cloned human dopamine D3 receptors, blocks 7-OH-DPAT-induced hypothermia in rats by Millan, M J, Audinot, V, Rivet, J M, Gobert, A, Vian, J, Prost, J F, Spedding, M, Peglion, J L

“…The selective dopamine D3 receptor agonist, 7-OH-DPAT ((+)-7-hydroxy-2-(di-n-propylamino)tetralin) and the novel naphthofurane, S 14297…”
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