Search Results - "Peggs, S"

Lost in Translation: Deciphering the Mechanism of Action of Anti-human CTLA-4 by Quezada, Sergio A, Peggs, Karl S

“…Despite a number of preclinical studies demonstrating that the activity of anti-CTLA-4 antibodies in murine models of cancer relies on effector T-cell…”
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Exploiting CTLA-4, PD-1 and PD-L1 to reactivate the host immune response against cancer by Quezada, S A, Peggs, K S

“…The past few years have witnessed something of a renaissance in the field of cancer immunotherapy, relating largely to the clinical advances that have been…”
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In vitro comparison of currently available and investigational antiviral agents against pathogenic human double-stranded DNA viruses: A systematic literature review by Chemaly, Roy F., Hill, Joshua A., Voigt, Sebastian, Peggs, Karl S.

“…Double-stranded (ds) DNA virus infections often occur concomitantly in immunocompromised patients. We performed a systematic search of published in vitro…”
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Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication by Quezada, Sergio A., Peggs, Karl S., Simpson, Tyler R., Allison, James P.

“…The continual interaction of the immune system with a developing tumor is thought to result in the establishment of a dynamic state of equilibrium. This…”
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Donor lymphocyte infusion following allogeneic hematopoietic stem cell transplantation by Roddie, Claire, Peggs, Karl S

“…Allogeneic hematopoietic stem cell transplantation (SCT) is the treatment of choice for many malignant hematological disorders. Following recent improvements…”
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CBETA: First Multipass Superconducting Linear Accelerator with Energy Recovery by Bartnik, A., Banerjee, N., Burke, D., Crittenden, J., Deitrick, K., Dobbins, J., Gulliford, C., Hoffstaetter, G. H., Li, Y., Lou, W., Quigley, P., Sagan, D., Smolenski, K., Berg, J. S., Brooks, S., Hulsart, R., Mahler, G., Meot, F., Michnoff, R., Peggs, S., Roser, T., Trbojevic, D., Tsoupas, N., Miyajima, T.

“…Energy recovery has been achieved in a multipass linear accelerator, demonstrating a technology for more compact particle accelerators operating at higher…”
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Epitope Landscape in Breast and Colorectal Cancer by SEGAL, Neil H, PARSONS, D. Williams, PEGGS, Karl S, VELCULESCU, Victor, KINZLER, Ken W, VOGELSTEIN, Bert, ALLISON, James P

“…The finding that individual cancers contain many mutant genes not present in normal tissues has prompted considerable interest in the cancer epitope landscape…”
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Cellular Therapeutic Approaches to Cytomegalovirus Infection Following Allogeneic Stem Cell Transplantation by Shafat, Manar S, Mehra, Vedika, Peggs, Karl S, Roddie, Claire

“…Cytomegalovirus (CMV) infection is common following allogeneic hematopoietic stem cell transplant (HSCT) and is a major cause of morbidity and increased…”
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Allogeneic stem cell transplantation as part of front line therapy for Mantle cell lymphoma by Rule, Simon, Cook, Gordon, Russell, Nigel H., Hunter, Ann, Robinson, Stephen, Morley, Nick, Sureda, Anna, Patrick, Pip, Clifton‐Hadley, Laura, Adedayo, Toyin, Kirkwood, Amy, Peggs, Karl S.

“…Summary Mantle cell lymphoma (MCL) is an aggressive form of non‐Hodgkin lymphoma that remains incurable for the majority of patients. Allogeneic stem cell…”
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Checkpoint blockade in cancer immunotherapy by Korman, Alan J, Peggs, Karl S, Allison, James P

“…The progression of a productive immune response requires that a number of immunological checkpoints be passed. Passage may require the presence of excitatory…”
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Allogeneic Hematopoietic Stem Cell Transplantation and Norovirus Gastroenteritis: A Previously Unrecognized Cause of Morbidity by Roddie, C., Paul, J. P. V., Benjamin, R., Gallimore, C. I., Xerry, J., Gray, J. J., Peggs, K. S., Morris, E. C., Thomson, K. J., Ward, K. N.

“…Background.A retrospective study of the clinical, epidemiologic, and virologic features of norovirus gastroenteritis in 12 adult allogeneic hematopoietic stem…”
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Directly Selected Cytomegalovirus-Reactive Donor T Cells Confer Rapid and Safe Systemic Reconstitution of Virus-Specific Immunity Following Stem Cell Transplantation by Peggs, Karl S., Thomson, Kirsty, Samuel, Edward, Dyer, Gemma, Armoogum, Julie, Chakraverty, Ronjon, Pang, Kwok, Mackinnon, Stephen, Lowdell, Mark W.

“…Background. Adoptive transfer of virus-specific T cells may accelerate reconstitution of antigen-specific immunity and limit the morbidity and mortality of…”
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Cancer immunotherapy: co-stimulatory agonists and co-inhibitory antagonists by Peggs, K.S, Quezada, S.A, Allison, J.P

“…The generation and maintenance of immune responses are controlled by both co-stimulatory and co-inhibitory signalling through T cell co-receptors, many of…”
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Long-term outcome analysis of reduced-intensity allogeneic stem cell transplantation in patients with mantle cell lymphoma: a retrospective study from the EBMT Lymphoma Working Party by Robinson, Stephen P., Boumendil, Ariane, Finel, Herve, Peggs, Karl S., Chevallier, Patrice, Sierra, Jorge, Finke, Jürgen, Poiré, Xavier, Maillard, Natacha, Milpied, Noël, Yakoub-Agha, Ibrahim, Koh, Mickey, Kröger, Nicolaus, Nagler, Arnon, Koc, Yener, Dietrich, Sascha, Montoto, Silvia, Dreger, Peter

“…Reduced-intensity allogeneic stem cell transplantation (RIST) is usually reserved for patients with mantle cell lymphoma who relapse after an autoSCT. However,…”
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Predictors of recovery following allogeneic CD34+-selected cell infusion without conditioning to correct poor graft function by Cuadrado, Maria M, Szydlo, Richard M, Watts, Mike, Patel, Nishil, Renshaw, Hanna, Dorman, Jude, Lowdell, Mark, Ings, Stuart, Anthias, Chloe, Madrigal, Alejandro, Mackinnon, Stephen, Kottaridis, Panagiotis, Carpenter, Ben, Hough, Rachael, Morris, Emma, Thomson, Kirsty, Peggs, Karl S, Chakraverty, Ronjon

“…Poor graft function is a serious complication following allogeneic hematopoietic stem cell transplantation. Infusion of CD34+-selected stem cells without…”
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Should all patients with Hodgkin lymphoma who relapse after autologous SCT be considered for allogeneic SCT? by Peggs, Karl S.

“…Abstract This article has a companion Counterpoint by Moskowitz…”
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Donor Lymphocyte Infusions Modulate Relapse Risk in Mixed Chimeras and Induce Durable Salvage in Relapsed Patients After T-Cell–Depleted Allogeneic Transplantation for Hodgkin's Lymphoma by PEGGS, Karl S, KAYANI, Irfan, THOMSON, Kirsty J, MACKINNON, Stephen, EDWARDS, Noha, KOTTARIDIS, Panagiotis, GOLDSTONE, Anthony H, LINCH, David C, HOUGH, Rachael, MORRIS, Emma C, FIELDING, Adele, CHAKRAVERTY, Ronjon

“…Reduced-intensity conditioning has minimized nonrelapse-related mortality rates after allogeneic transplantation in patients with Hodgkin's lymphoma, and…”
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Cytomegalovirus (CMV) Cell-Mediated Immunity and CMV Infection After Allogeneic Hematopoietic Cell Transplantation: The REACT Study by Chemaly, Roy F, El Haddad, Lynn, Winston, Drew J, Rowley, Scott D, Mulane, Kathleen M, Chandrasekar, Pranatharthi, Avery, Robin K, Hari, Parameswaran, Peggs, Karl S, Kumar, Deepali, Nath, Rajneesh, Ljungman, Per, Mossad, Sherif B, Dadwal, Sanjeet S, Blanchard, Ted, Shah, Dimpy P, Jiang, Ying, Ariza-Heredia, Ella

“…Abstract Background Cytomegalovirus (CMV) infection remains an important cause of morbidity and mortality in allogeneic hematopoietic cell transplant…”
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Cytomegalovirus-Specific T Cell Immunotherapy Promotes Restoration of Durable Functional Antiviral Immunity following Allogeneic Stem Cell Transplantation by Peggs, Karl S., Verfuerth, Stephanie, Pizzey, Arnold, Chow, Shoon-Ling C., Thomson, Kirsty, Mackinnon, Stephen

“…Background.The profound immunodeficiency associated with allogeneic hematopoietic stem cell transplantation is permissive to uncontrolled replication of latent…”
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Evolving adoptive cellular therapies in urological malignancies by Wong, Yien Ning Sophia, MD, Joshi, Kroopa, MD, Pule, Martin, MD, Peggs, Karl S, Prof, Swanton, Charles, Prof, Quezada, Sergio A, PhD, Linch, Mark, Dr

“…Summary Immunotherapies have long been used to treat urological cancers but rarely lead to cure. In the past 5 years, success of immune checkpoint inhibition…”
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