Search Results - "Peferoen, Laura A N"

Inflammation in neurodegenerative diseases – an update by Amor, Sandra, Peferoen, Laura A. N., Vogel, Daphne Y. S., Breur, Marjolein, Valk, Paul, Baker, David, Noort, Johannes M.

“…Summary Neurodegeneration, the progressive dysfunction and loss of neurons in the central nervous system (CNS), is the major cause of cognitive and motor…”
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Hallmarks of a genomically distinct subclass of head and neck cancer by Muijlwijk, Tara, Nauta, Irene H., van der Lee, Anabel, Grünewald, Kari J. T., Brink, Arjen, Ganzevles, Sonja H., Baatenburg de Jong, Robert J., Atanesyan, Lilit, Savola, Suvi, van de Wiel, Mark A., Peferoen, Laura A. N., Bloemena, Elisabeth, van de Ven, Rieneke, Leemans, C. René, Poell, Jos B., Brakenhoff, Ruud H.

“…Cancer is caused by an accumulation of somatic mutations and copy number alterations (CNAs). Besides mutations, these copy number changes are key…”
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GM‐CSF promotes migration of human monocytes across the blood brain barrier by Vogel, Daphne Y. S., Kooij, Gijs, Heijnen, Priscilla D. A. M., Breur, Marjolein, Peferoen, Laura A. N., Valk, Paul, Vries, Helga E., Amor, Sandra, Dijkstra, Christine D.

“…Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). Infiltration of monocytes into the CNS is crucial…”
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Astrocyte and Oligodendrocyte Cross-Talk in the Central Nervous System by Nutma, Erik, van Gent, Démi, Amor, Sandra, Peferoen, Laura A N

“…Over the last decade knowledge of the role of astrocytes in central nervous system (CNS) neuroinflammatory diseases has changed dramatically. Rather than…”
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Design and evaluation of an immunology and pathology course that is tailored to today's dentistry students by de Vries, Teun J, Schoenmaker, Ton, Peferoen, Laura A N, Krom, Bastiaan P, Bloemena, Elisabeth

“…Curricular reform provides new opportunities to renovate important pillars of the dentistry curriculum, such as immunology and pathology, with novel approaches…”
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Demyelination during multiple sclerosis is associated with combined activation of microglia/macrophages by IFN-γ and alpha B-crystallin by Bsibsi, Malika, Peferoen, Laura A. N., Holtman, Inge R., Nacken, Peter J., Gerritsen, Wouter H., Witte, Maarten E., van Horssen, Jack, Eggen, Bart J. L., van der Valk, Paul, Amor, Sandra, van Noort, Johannes M.

“…Activated microglia and macrophages play a key role in driving demyelination during multiple sclerosis (MS), but the factors responsible for their activation…”
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Immune cell topography of head and neck cancer by Muijlwijk, Tara, Nijenhuis, Dennis N L M, Ganzevles, Sonja H, Ekhlas, Fatima, Ballesteros-Merino, Carmen, Peferoen, Laura A N, Bloemena, Elisabeth, Fox, Bernard A, Poell, Jos B, Leemans, C René, Brakenhoff, Ruud H, van de Ven, Rieneke

“…BackgroundApproximately 50% of head and neck squamous cell carcinomas (HNSCC) recur after treatment with curative intent. Immune checkpoint inhibitors are…”
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Pentraxin‐3 is upregulated in the central nervous system during MS and EAE, but does not modulate experimental neurological disease by Ummenthum, Kimberley, Peferoen, Laura A. N., Finardi, Annamaria, Baker, David, Pryce, Gareth, Mantovani, Alberto, Bsibsi, Malika, Bottazzi, Barbara, Peferoen‐Baert, Regina, van der Valk, Paul, Garlanda, Cecilia, Kipp, Markus, Furlan, Roberto, van Noort, Johannes M., Amor, Sandra

“…Pentraxin‐3 (PTX3), an acute‐phase protein released during inflammation, aids phagocytic clearance of pathogens and apoptotic cells, and plays diverse…”
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Circulating T cell status and molecular imaging may predict clinical benefit of neoadjuvant PD-1 blockade in oral cancer by Wondergem, Niels E, Miedema, Iris H C, van de Ven, Rieneke, Zwezerijnen, Gerben J C, de Graaf, Pim, Karagozoglu, K Hakki, Hendrickx, Jan-Jaap, Eerenstein, Simone E J, Bun, Rolf J, Mulder, Dorien C, Voortman, Jens, Boellaard, Ronald, Windhorst, Albert D, Hagers, J Pascal, Peferoen, Laura A N, de Gruijl, Tanja D, Bloemena, Elisabeth, Brakenhoff, Ruud H, Leemans, C René, Menke-van der Houven van Oordt, C Willemien

“…BackgroundAddition of neoadjuvant immune checkpoint inhibition to standard-of-care interventions for locally advanced oral cancer could improve clinical…”
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Small heat shock proteins are induced during multiple sclerosis lesion development in white but not grey matter by Peferoen, Laura A N, Gerritsen, Wouter H, Breur, Marjolein, Ummenthum, Kimberley M D, Peferoen-Baert, Regina M B, van der Valk, Paul, van Noort, Johannes M, Amor, Sandra

“…The important protective role of small heat-shock proteins (HSPs) in regulating cellular survival and migration, counteracting protein aggregation, preventing…”
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Metal ions potentiate microglia responsiveness to endotoxin by Rachmawati, Dessy, Peferoen, Laura A.N, Vogel, Daphne Y.S, Alsalem, Inás W.A, Amor, Sandra, Bontkes, Hetty J, von Blomberg, B. Mary E, Scheper, Rik J, van Hoogstraten, Ingrid M.W

“…Abstract Oral metal exposure has been associated with diverse adverse reactions, including neurotoxicity. We showed previously that dentally applied metals…”
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Architectural dysplasia in surgical margins and the risk of local relapse in oral cancer by Nauta, Irene H, Peferoen, Laura A N, Brakenhoff, Ruud H, Leemans, C René, Bloemena, Elisabeth

“…A major challenge in the clinical management of oral cavity squamous cell carcinoma is local relapse. Even when surgical margins are tumor-free, local relapses…”
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Activation Status of Human Microglia Is Dependent on Lesion Formation Stage and Remyelination in Multiple Sclerosis by Peferoen, Laura A.N, Vogel, Daphne Y.S, Ummenthum, Kimberley, Breur, Marjolein, Heijnen, Priscilla D.A.M, Gerritsen, Wouter H, Peferoen-Baert, Regina M.B, van der Valk, Paul, Dijkstra, Christine D, Amor, Sandra

“…ABSTRACTSimilar to macrophages, microglia adopt diverse activation states and contribute to repair and tissue damage in multiple sclerosis. Using reverse…”
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Pro-inflammatory activation of primary microglia and macrophages increases 18 kDa translocator protein expression in rodents but not humans by Owen, David R, Narayan, Nehal, Wells, Lisa, Healy, Luke, Smyth, Erica, Rabiner, Eugenii A, Galloway, Dylan, Williams, John B, Lehr, Joshua, Mandhair, Harpreet, Peferoen, Laura AN, Taylor, Peter C, Amor, Sandra, Antel, Jack P, Matthews, Paul M, Moore, Craig S

“…The 18kDa Translocator Protein (TSPO) is the most commonly used tissue-specific marker of inflammation in positron emission tomography (PET) studies. It is…”
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The role of differentiated dysplasia in the prediction of malignant transformation of oral leukoplakia by Wils, Leon J., Poell, Jos B., Peferoen, Laura A. N., Evren, Ilkay, Brouns, Elisabeth R., de Visscher, Jan G. A. M., van der Meij, Erik H., Brakenhoff, Ruud H., Bloemena, Elisabeth

“…ObjectiveOral leukoplakia is the most common oral potentially malignant disorder. Malignant transformation of oral leukoplakia occurs at an annual rate of…”
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The value of regular follow‐up of oral leukoplakia for early detection of malignant transformation by Evren, Ilkay, Najim, Ahmad M., Poell, Jos B., Brouns, Elisabeth R., Wils, Leon J., Peferoen, Laura A. N., Brakenhoff, Ruud H., Bloemena, Elisabeth, Meij, Erik H., Visscher, Jan G. A. M.

“…Objectives Evaluate whether regular follow‐up of oral leukoplakia (OL) resulted in early detection of malignant transformation (MT). Method Two hundred and…”
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Ageing and recurrent episodes of neuroinflammation promote progressive experimental autoimmune encephalomyelitis in Biozzi ABH mice by Peferoen, Laura A. N., Breur, Marjolein, Berg, Sarah, Peferoen‐Baert, Regina, Boddeke, Erik H. W. G. M., Valk, Paul, Pryce, Gareth, Noort, Johannes M., Baker, David, Amor, Sandra

“…Summary Current therapies for multiple sclerosis (MS) reduce the frequency of relapses by modulating adaptive immune responses but fail to limit the…”
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Epstein Barr virus is not a characteristic feature in the central nervous system in established multiple sclerosis by Peferoen, Laura A. N., Lamers, Floris, Lodder, Lenthe N. R., Gerritsen, Wouter H., Huitinga, Inge, Melief, Jeroen, Giovannoni, Gavin, Meier, Ute, Hintzen, Rogier Q., Verjans, Georges M. G. M., van Nierop, Gijsbert P., Vos, Wim, Peferoen-Baert, Regina M. B., Middeldorp, Jaap M., van der Valk, Paul, Amor, Sandra

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Cover Image by Wils, Leon J., Poell, Jos B., Peferoen, Laura A. N., Evren, Ilkay, Brouns, Elisabeth R., de Visscher, Jan G. A. M., van der Meij, Erik H., Brakenhoff, Ruud H., Bloemena, Elisabeth

“…The cover image is based on the Original Article The role of differentiated dysplasia in the prediction of malignant transformation of oral leukoplakia by Leon…”
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Demyelination during multiple sclerosis is associated with combined activation of microglia/macrophages by IFN-[gamma] and alpha B-crystallin by Bsibsi, Malika, Peferoen, Laura A; N, Holtman, Inge R, Nacken, Peter J, Gerritsen, Wouter H, Witte, Maarten E, van Horssen, Jack, Eggen, Bart J; L, van der Valk, Paul, Amor, Sandra, van Noort, Johannes M

“…Activated microglia and macrophages play a key role in driving demyelination during multiple sclerosis (MS), but the factors responsible for their activation…”
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