Search Results - "Peerschke, Ellinor"

Complement and coagulation: key triggers of COVID-19-induced multiorgan pathology by Ghebrehiwet, Berhane, Peerschke, Ellinor I

“…In a stunningly short period of time, the unexpected coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2…”
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The complement and contact activation systems: partnership in pathogenesis beyond angioedema by Ghebrehiwet, Berhane, Kaplan, Allen P., Joseph, Kusumam, Peerschke, Ellinor I. B.

“…Summary The blood plasma contains four biologically important proteolytic cascades, which probably evolved from the same ancestral gene. This in part may…”
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Classical complement pathway activation in immune thrombocytopenia purpura: inhibition by a novel C1s inhibitor by Peerschke, Ellinor I. B., Panicker, Sandip, Bussel, James

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Guideline for Reversal of Antithrombotics in Intracranial Hemorrhage: A Statement for Healthcare Professionals from the Neurocritical Care Society and Society of Critical Care Medicine by Frontera, Jennifer A., Lewin III, John J., Rabinstein, Alejandro A., Aisiku, Imo P., Alexandrov, Anne W., Cook, Aaron M., del Zoppo, Gregory J., Kumar, Monisha A., Peerschke, Ellinor I. B., Stiefel, Michael F., Teitelbaum, Jeanne S, Wartenberg, Katja E., Zerfoss, Cindy L.

“…Background The use of antithrombotic agents, including anticoagulants, antiplatelet agents, and thrombolytics has increased over the last decade and is…”
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Guideline for Reversal of Antithrombotics in Intracranial Hemorrhage by Frontera, Jennifer A, Lewin III, John J, Rabinstein, Alejandro A, Aisiku, Imo P, Alexandrov, Anne W, Cook, Aaron M, del Zoppo, Gregory J, Kumar, Monisha A, Peerschke, Ellinor I. B, Stiefel, Michael F, Teitelbaum, Jeanne S, Wartenberg, Katja E, Zerfoss, Cindy L

“…BackgroundThe use of antithrombotic agents, including anticoagulants, antiplatelet agents, and thrombolytics has increased over the last decade and is expected…”
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cC1qR/CR and gC1qR/p33: observations in cancer by Peerschke, Ellinor I B, Ghebrehiwet, Berhane

“…The survival and growth of a primary tumor depends, by and large, on three major events: immune evasion, angiogenesis and metastasis. Tumor cells are "modified…”
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Complement activation on platelets correlates with a decrease in circulating immature platelets in patients with immune thrombocytopenic purpura by Peerschke, Ellinor I. B., Andemariam, Biree, Yin, Wei, Bussel, James B.

“…Summary The role of the complement system in immune thrombocytopenic purpura (ITP) is not well defined. We examined plasma from 79 patients with ITP, 50…”
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Complement activation on platelets: Implications for vascular inflammation and thrombosis by Peerschke, Ellinor I., Yin, Wei, Ghebrehiwet, Berhane

“…Platelets participate in a variety of responses of the blood to injury. An emerging body of evidence suggests that these cells express an intrinsic capacity to…”
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C1q as an autocrine and paracrine regulator of cellular functions by Ghebrehiwet, Berhane, Hosszu, Kinga H., Peerschke, Ellinor I.B.

“…•Monocyte/dendritic cell (DC) expressed C1q is a molecular sensor of danger.•Antigen-free C1q keeps DCs in a tolerogenic phenotype.•Danger-­loaded C1q…”
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SARS-CoV-2 Exacerbates COVID-19 Pathology Through Activation of the Complement and Kinin Systems by Savitt, Anne G, Manimala, Samantha, White, Tiara, Fandaros, Marina, Yin, Wei, Duan, Huiquan, Xu, Xin, Geisbrecht, Brian V, Rubenstein, David A, Kaplan, Allen P, Peerschke, Ellinor I, Ghebrehiwet, Berhane

“…Infection with SARS-CoV-2 triggers the simultaneous activation of innate inflammatory pathways including the complement system and the kallikrein-kinin system…”
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Reduction of neutrophil activity decreases early microvascular injury after subarachnoid haemorrhage by Friedrich, Victor, Flores, Rowena, Muller, Artur, Bi, Weina, Peerschke, Ellinor Ib, Sehba, Fatima A

“…Subarachnoid haemorrhage (SAH) elicits rapid pathological changes in the structure and function of parenchymal vessels (≤ 100 μm). The role of neutrophils in…”
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Thromboinflammation Supports Complement Activation in Cancer Patients With COVID-19 by Peerschke, Ellinor I, Valentino, Alisa, So, Rachel J, Shulman, Scott, Ravinder

“…COVID-19 pathology is associated with exuberant inflammation, vascular damage, and activation of coagulation. In addition, complement activation has been…”
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SLE: Novel Postulates for Therapeutic Options by Hosszu, Kinga K, Valentino, Alisa, Peerschke, Ellinor I, Ghebrehiwet, Berhane

“…Genetic deficiency in C1q is a strong susceptibility factor for systemic lupus erythematosus (SLE). There are two major hypotheses that potentially explain the…”
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Guideline for Reversal of Antithrombotics in Intracranial Hemorrhage: Executive Summary. A Statement for Healthcare Professionals From the Neurocritical Care Society and the Society of Critical Care Medicine by Frontera, Jennifer A., Lewin, John J., Rabinstein, Alejandro A., Aisiku, Imo P., Alexandrov, Anne W., Cook, Aaron M., del Zoppo, Gregory J., Kumar, Monisha, Peerschke, Ellinor I. B., Stiefel, Michael F., Teitelbaum, Jeanne S., Wartenberg, Katja E., Zerfoss, Cindy L.

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Reference range determination for whole-blood platelet aggregation using the Multiplate analyzer by Peerschke, Ellinor I B, Castellone, Donna D, Stroobants, A K, Francis, John

“…To develop reference ranges for platelet aggregation using the Multiplate analyzer (Roche Diagnostics, Mannheim, Germany) in blood anticoagulated with sodium…”
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DC-SIGN, C1q, and gC1qR form a trimolecular receptor complex on the surface of monocyte-derived immature dendritic cells by Hosszu, Kinga K., Valentino, Alisa, Vinayagasundaram, Uma, Vinayagasundaram, Rama, Joyce, M. Gordon, Ji, Yan, Peerschke, Ellinor I.B., Ghebrehiwet, Berhane

“…C1q modulates the differentiation and function of cells committed to the monocyte-derived dendritic cell (DC) lineage. Because the 2 C1q receptors found on the…”
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HITTING the Diagnosis: Testing for Heparin-Induced Thrombocytopenia in Cancer Patients by Fenelus, Maly, Peerschke, Ellinor I B

“…To evaluate the use of a pretest probability score (4Ts score) in cancer patients to guide ordering of laboratory screening tests for heparin-induced…”
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Choosing wisely during the COVID-19 pandemic: optimising outpatient cancer care while conserving resources with a new algorithm to report automated ANC results by Fenelus, Maly, Graham, Tamiqua, Golden, Ryan, Bautista, Jessica L, So, Rachel J, Plante, Nora, Peerschke, Ellinor I B

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The C1q and gC1qR axis as a novel checkpoint inhibitor in cancer by Ghebrehiwet, Berhane, Zaniewski, Michal, Fernandez, Audrey, DiGiovanni, Mathew, Reyes, Tiana N, Ji, Ping, Savitt, Anne G, Williams, Jennie L, Seeliger, Markus A, Peerschke, Ellinor I B

“…Understanding at the molecular level of the cell biology of tumors has led to significant treatment advances in the past. Despite such advances however,…”
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von Willebrand Factor Assay Proficiency Testing: The North American Specialized Coagulation Laboratory Association Experience by CHANDLER, Wayne L, PEERSCHKE, Ellinor I. B, CASTELLONE, Donna D, MEIJER, Piet

“…We evaluated the accuracy and precision of von Willebrand disease (vWD) testing performed by up to 50 North American Specialty Coagulation Laboratories from…”
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