Search Results - "Peeper, D S"

Zeb1 is required for TrkB-induced epithelial-mesenchymal transition, anoikis resistance and metastasis by Smit, M A, Peeper, D S

“…Anoikis (detachment-induced apoptosis) prevents the survival of cells at inappropriate sites of the body and can therefore act as a barrier to metastasis. In a…”
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Oncogene-Induced Cell Senescence — Halting on the Road to Cancer by Mooi, W.J, Peeper, D.S

“…This review of oncogene-induced cell senescence describes a physiological mechanism that provides protection against cancer. The mechanisms underlying the…”
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Presence of a 34-gene signature is a favorable prognostic marker in squamous non-small cell lung carcinoma by Theelen, W S M E, Krijgsman, O, Monkhorst, K, Kuilman, T, Peters, D D G C, Cornelissen, S, Ligtenberg, M A, Willems, S M, Blaauwgeers, J L G, van Noesel, C J M, Peeper, D S, van den Heuvel, M M, Schulze, K

“…The tumor immune microenvironment is a heterogeneous entity. Gene expression analysis allows us to perform comprehensive immunoprofiling and may assist in…”
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The neurotrophic receptor TrkB: a drug target in anti-cancer therapy? by Desmet, C J, Peeper, D S

“…Increasing evidence implies altered signaling through the neurotrophic receptor tyrosine kinase TrkB in promoting tumor formation and metastasis. TrkB,…”
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P12.03 Heterotypic CD8 T cell clusters isolated from clinical samples are distinct and enriched for antitumor activity by Ibáñez Molero, S, Veldman, J, Traets, JJH, George, A, Hoefakker, K, Pack, S, Tas, L, Alóndiga-Mérida, P, van den Broek, B, Harkes, R, Nieuwland, M, van Baalen, M, Mul, E, Tol, S, Haanen, JBAG, Houdt, WJv, Peeper, DS

“…BackgroundAn increasing body of evidence suggests that in addition to the type, density, and state of immune cells in the tumor microenvironment (TME), also…”
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Cell cycle-specific association of E2F with the p130 E1A-binding protein by COBRINIK, D, WHYTE, P, PEEPER, D. S, JACKS, T, WEINBERG, R. A

“…Association of the E2F transcription factor with the pRb and p107 proteins appears to regulate the activity of E2F and, in turn, affect cell cycle progression…”
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BRAF in benign and malignant human tumours by Michaloglou, C, Vredeveld, L C W, Mooi, W J, Peeper, D S

“…Of the RAF family of protein kinases, BRAF is the only member to be frequently activated by mutation in cancer. A single amino acid substitution (V600E)…”
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Survival and biomarker analyses from the OpACIN-neo and OpACIN neoadjuvant immunotherapy trials in stage III melanoma by Rozeman, E. A., Hoefsmit, E. P., Reijers, I. L. M., Saw, R. P. M., Versluis, J. M., Krijgsman, O., Dimitriadis, P., Sikorska, K., van de Wiel, B. A., Eriksson, H., Gonzalez, M., Torres Acosta, A., Grijpink-Ongering, L. G., Shannon, K., Haanen, J. B. A. G., Stretch, J., Ch’ng, S., Nieweg, O. E., Mallo, H. A., Adriaansz, S., Kerkhoven, R. M., Cornelissen, S., Broeks, A., Klop, W. M. C., Zuur, C. L., van Houdt, W. J., Peeper, D. S., Spillane, A. J., van Akkooi, A. C. J., Scolyer, R. A., Schumacher, T. N. M., Menzies, A. M., Long, G. V., Blank, C. U.

“…Neoadjuvant ipilimumab plus nivolumab showed high pathologic response rates (pRRs) in patients with macroscopic stage III melanoma in the phase 1b OpACIN (…”
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Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein by Peeper, Daniel S, Upton, Todd M, Ladha, Mohamed H, Neuman, Elizabeth, Zalvide, Juan, Bernards, René, DeCaprio, James A, Ewen, Mark E

“…The Ras proto-oncogene is a central component of mitogenic signal-transduction pathways, and is essential for cells both to leave a quiescent state (G0) and to…”
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Escape from premature senescence is not sufficient for oncogenic transformation by Ras by Bernards, René, Peeper, Daniel S, Dannenberg, Jan-Hermen, Douma, Sirith, Riele, Hein te

“…Resistance of primary cells to transformation by oncogenic Ras has been attributed to the induction of replicative growth arrest. This irreversible 'fail-safe…”
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The (re)discovery of tumor-intrinsic determinants of immune sensitivity by functional genetic screens by Vredevoogd, D.W., Apriamashvili, G., Peeper, D.S.

“…Functional genetic screens by CRISPR-Cas9 allow for the unbiased discovery of proteins causally involved in complex biological processes. In recent years, this…”
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Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors by Azimi, Alireza, Caramuta, Stefano, Seashore‐Ludlow, Brinton, Boström, Johan, Robinson, Jonathan L, Edfors, Fredrik, Tuominen, Rainer, Kemper, Kristel, Krijgsman, Oscar, Peeper, Daniel S, Nielsen, Jens, Hansson, Johan, Egyhazi Brage, Suzanne, Altun, Mikael, Uhlen, Mathias, Maddalo, Gianluca

“…Novel therapies are undergoing clinical trials, for example, the Hsp90 inhibitor, XL888, in combination with BRAF inhibitors for the treatment of…”
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Adenovirus-E1A proteins transform cells by sequestering regulatory proteins by PEEPER, D. S, ZANTEMA, A

“…Cell transformation by adenovirus-E1A proteins is mediated by binding to cellular proteins whose functions are thereby inactivated or altered. The various…”
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BRAFE600 in benign and malignant human tumours by Michaloglou, C, Vredeveld, L C W, Mooi, W J, Peeper, D S

“…Of the RAF family of protein kinases, BRAF is the only member to be frequently activated by mutation in cancer. A single amino acid substitution (V600E)…”
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A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence by Bernards, René, Peeper, Daniel S, Shvarts, Avi, Brummelkamp, Thijn, Douma, Sirith, Koh, Eugene Y, Daley, George Q

“…Primary fibroblasts respond to activated H-RASV12 by undergoing premature arrest, which resembles replicative senescence. This irreversible 'fail-safe…”
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p53-dependent repression of CDK4 translation in TGF-beta-induced G1 cell-cycle arrest by Ewen, M E, Oliver, C J, Sluss, H K, Miller, S J, Peeper, D S

“…Transforming growth factor beta 1 (TGF-beta 1) can cause a cell-cycle arrest in G1. Inhibition of cyclin-dependent kinase 4 (cdk4) synthesis plays a…”
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Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network by Kuilman, Thomas, Michaloglou, Chrysiis, Vredeveld, Liesbeth C.W., Douma, Sirith, van Doorn, Remco, Desmet, Christophe J., Aarden, Lucien A., Mooi, Wolter J., Peeper, Daniel S.

“…Oncogene-induced cellular senescence (OIS) is emerging as a potent cancer-protective response to oncogenic events, serving to eliminate early neoplastic cells…”
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A‐ and B‐type cyclins differentially modulate substrate specificity of cyclin‐cdk complexes by Peeper, D.S., Parker, L.L., Ewen, M.E., Toebes, M., Hall, F.L., Xu, M., Zantema, A., Eb, A.J., Piwnica‐Worms, H.

“…Both cyclins A and B associate with and thereby activate cyclin‐dependent protein kinases (cdks). We have investigated which component in the cyclin‐cdk…”
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Communication between the extracellular environment, cytoplasmic signalling cascades and the nuclear cell-cycle machinery by Peeper, Daniel S, Bernards, René

“…In the past decade, we have gained considerable insight into the identities of various cytoplasmic signal transduction cascades and the manner in which they…”
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Molecular cloning of a pair of human pepsinogen A genes which differ by a Glu→Lys mutation in the activation peptide by EVERS, M. P. J, ZELLE, B, PEEPER, D. S, MAGER, W. H, PLANTA, R. J, ERIKSSON, A. W, FRANTS, R. R

“…Three human cosmid clones containing pepsinogen A (PGA) encoding sequences were isolated from a genomic bank derived from a single individual. One cosmid…”
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