Search Results - "Peelor, Frederick F."

Nrf2 Signaling and the Slowed Aging Phenotype: Evidence from Long-Lived Models by Miller, Benjamin F., Peelor, Frederick F., Biela, Laurie M., Drake, Joshua C., Bruns, Danielle R., Hamilton, Karyn L.

“…Studying long-lived animals provides novel insight into shared characteristics of aging and represents a unique model to elucidate approaches to prevent…”
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Muscle‐specific changes in protein synthesis with aging and reloading after disuse atrophy by Miller, Benjamin F., Baehr, Leslie M., Musci, Robert V., Reid, Justin J., Peelor, Frederick F., Hamilton, Karyn L., Bodine, Sue C.

“…Background Successful strategies to halt or reverse sarcopenia require a basic understanding of the factors that cause muscle loss with age. Acute periods of…”
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Differential effects of vitamin C or protandim on skeletal muscle adaptation to exercise by Bruns, Danielle R, Ehrlicher, Sarah E, Khademi, Shadi, Biela, Laurie M, Peelor, 3rd, Frederick F, Miller, Benjamin F, Hamilton, Karyn L

“…Maintaining proteostasis is a key mechanism for preserving cell function. Exercise-stimulated proteostasis is regulated, in part, by redox-sensitive signaling…”
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Effect of biological sex and short-term high-fat diet on cellular proliferation, ribosomal biogenesis, and targeted protein abundance in murine articular cartilage by Kobak, Kamil A., Batushansky, Albert, Jopkiewicz, Anita, Peelor, Frederick F., Kinter, Michael T., Miller, Benjamin F., Griffin, Timothy M.

“…To identify factors contributing to sex-differences in OA risk by evaluating the short-term effect of high-fat (HF) diet on sex-specific changes in cartilage…”
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Determining the contributions of protein synthesis and breakdown to muscle atrophy requires non‐steady‐state equations by Kobak, Kamil A., Lawrence, Marcus M., Pharaoh, Gavin, Borowik, Agnieszka K., Peelor, Frederick F., Shipman, Patrick D., Griffin, Timothy M., Van Remmen, Holly, Miller, Benjamin F.

“…Background Ageing and cachexia cause a loss of muscle mass over time, indicating that protein breakdown exceeds protein synthesis. Deuterium oxide (D2O) is…”
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A Novel Stable Isotope Approach Demonstrates Surprising Degree of Age-Related Decline in Skeletal Muscle Collagen Proteostasis by Abbott, Claire B, Lawrence, Marcus M, Kobak, Kamil A, Lopes, Erika Barboza Prado, Peelor, 3rd, Frederick F, Donald, Elizabeth J, Van Remmen, Holly, Griffin, Timothy M, Miller, Benjamin F

“…Age-related deterioration in turnover of collagen proteins accelerates extracellular matrix fibrosis and hinders adaptation to external stimuli. This project…”
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The loss of cardiac SIRT3 decreases metabolic flexibility and proteostasis in an age-dependent manner by Li, Ping, Newhardt, Maria F., Matsuzaki, Satoshi, Eyster, Craig, Pranay, Atul, Peelor, Frederick F., Batushansky, Albert, Kinter, Caroline, Subramani, Kumar, Subrahmanian, Sandeep, Ahamed, Jasimuddin, Yu, Pengchun, Kinter, Michael, Miller, Benjamin F., Humphries, Kenneth M.

“…SIRT3 is a longevity factor that acts as the primary deacetylase in mitochondria. Although ubiquitously expressed, previous global SIRT3 knockout studies have…”
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Impaired proteostatic mechanisms other than decreased protein synthesis limit old skeletal muscle recovery after disuse atrophy by Fuqua, Jordan D, Lawrence, Marcus M, Hettinger, Zachary R, Borowik, Agnieszka K, Brecheen, Parker L, Szczygiel, Marcelina M, Abbott, Claire B, Peelor, 3rd, Frederick F, Confides, Amy L, Kinter, Michael, Bodine, Sue C, Dupont-Versteegden, Esther E, Miller, Benjamin F

“…Skeletal muscle mass and strength diminish during periods of disuse but recover upon return to weight bearing in healthy adults but are incomplete in old…”
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Enhanced skeletal muscle regrowth and remodelling in massaged and contralateral non‐massaged hindlimb by Miller, Benjamin F., Hamilton, Karyn L., Majeed, Zana R., Abshire, Sarah M., Confides, Amy L., Hayek, Amanda M., Hunt, Emily R., Shipman, Patrick, Peelor, Frederick F., Butterfield, Timothy A., Dupont‐Versteegden, Esther E.

“…Key points Muscle fibre cross sectional area is enhanced with massage in the form of cyclic compressive loading during regrowth after atrophy. Massage enhances…”
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The Dunkin Hartley Guinea Pig Is a Model of Primary Osteoarthritis That Also Exhibits Early Onset Myofiber Remodeling That Resembles Human Musculoskeletal Aging by Musci, Robert V., Walsh, Maureen A., Konopka, Adam R., Wolff, Christopher A., Peelor, Frederick F., Reiser, Raoul F., Santangelo, Kelly S., Hamilton, Karyn L.

“…Skeletal muscle dysfunction, articular cartilage degeneration, and bone loss occur essentially in parallel during aging. Mechanisms contributing to this…”
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Greater muscle protein synthesis and mitochondrial biogenesis in males compared with females during sprint interval training by Scalzo, Rebecca L., Peltonen, Garrett L., Binns, Scott E., Shankaran, Mahalakshmi, Giordano, Gregory R., Hartley, Dylan A., Klochak, Anna L., Lonac, Mark C., Paris, Hunter L. R., Szallar, Steve E., Wood, Lacey M., Peelor, Frederick F., Holmes, William E., Hellerstein, Marc K., Bell, Christopher, Hamilton, Karyn L., Miller, Benjamin F.

“…ABSTRACT Improved endurance exercise performance in adult humans after sprint interval training (SIT) has been attributed to mitochondrial biogenesis. However,…”
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Age-induced changes in skeletal muscle mitochondrial DNA synthesis, quantity, and quality in genetically unique rats by Musci, Robert V, Fuqua, Jordan D, Peelor, 3rd, Frederick F, Nguyen, Hoang Van Michelle, Richardson, Arlan, Choi, Solbie, Miller, Benjamin F, Wanagat, Jonathan

“…Mitochondrial genomic integrity is a key element of physiological processes and health. Changes in the half-life of the mitochondrial genome are implicated in…”
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17α-estradiol, a lifespan-extending compound, attenuates liver fibrosis by modulating collagen turnover rates in male mice by Ali Mondal, Samim, Sathiaseelan, Roshini, Mann, Shivani N, Kamal, Maria, Luo, Wenyi, Saccon, Tatiana D, Isola, José V V, Peelor, 3rd, Frederick F, Li, Tiangang, Freeman, Willard M, Miller, Benjamin F, Stout, Michael B

“…Estrogen signaling is protective against chronic liver diseases, although men and a subset of women are contraindicated for chronic treatment with…”
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Assessment of mitochondrial biogenesis and mTORC1 signaling during chronic rapamycin feeding in male and female mice by Drake, Joshua C, Peelor, 3rd, Frederick F, Biela, Laurie M, Watkins, Molly K, Miller, Richard A, Hamilton, Karyn L, Miller, Benjamin F

“…Chronic inhibition of the protein synthesis regulator mTORC1 through rapamycin extends life span in mice, with longer extension in females than in males…”
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Massage as a mechanotherapy promotes skeletal muscle protein and ribosomal turnover but does not mitigate muscle atrophy during disuse in adult rats by Lawrence, Marcus M., Van Pelt, Douglas W., Confides, Amy L., Hunt, Emily R., Hettinger, Zachary R., Laurin, Jaime L., Reid, Justin J., Peelor, Frederick F., Butterfield, Timothy A., Dupont‐Versteegden, Esther E., Miller, Benjamin F.

“…Aim Interventions that decrease atrophy during disuse are desperately needed to maintain muscle mass. We recently found that massage as a mechanotherapy can…”
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Dietary Methionine Restriction Regulates Liver Protein Synthesis and Gene Expression Independently of Eukaryotic Initiation Factor 2 Phosphorylation in Mice by Pettit, Ashley P, Jonsson, William O, Bargoud, Albert R, Mirek, Emily T, Peelor, 3rd, Frederick F, Wang, Yongping, Gettys, Thomas W, Kimball, Scot R, Miller, Benjamin F, Hamilton, Karyn L, Wek, Ronald C, Anthony, Tracy G

“…The phosphorylation of eukaryotic initiation factor 2 (p-eIF2) during dietary amino acid insufficiency reduces protein synthesis and alters gene expression via…”
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Skeletal and cardiac muscle have different protein turnover responses in a model of right heart failure by Bruns, Danielle R., McNair, Benjamin D., Peelor, Frederick F., Borowik, Agnieszka K., Pranay, Atul, Yusifov, Aykhan, Miller, Benjamin F.

“…Right heart failure (RHF) is a common and deadly disease in aged populations. Extra-cardiac outcomes of RHF such as skeletal muscle atrophy contribute to…”
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Adrenergic control of lipolysis in women compared with men by Schmidt, Stacy L, Bessesen, Daniel H, Stotz, Sarah, Peelor, 3rd, Frederick F, Miller, Benjamin F, Horton, Tracy J

“…Data suggest women are more sensitive to the lipolytic action of epinephrine compared with men while maintaining similar glucoregulatory effects (Horton et al…”
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An In Vivo Stable Isotope Labeling Method to Investigate Individual Matrix Protein Synthesis, Ribosomal Biogenesis, and Cellular Proliferation in Murine Articular Cartilage by Kobak, Kamil A, Batushansky, Albert, Borowik, Agnieszka K, Lopes, Erika Prado Barboza, Peelor Iii, Frederick F, Donovan, Elise L, Kinter, Michael T, Miller, Benjamin F, Griffin, Timothy M

“…Targeting chondrocyte dynamics is a strategy for slowing osteoarthritis progression during aging. We describe a stable-isotope method using in vivo deuterium…”
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Participation in a 1,000-mile race increases the oxidation of carbohydrate in Alaskan sled dogs by Miller, Benjamin F, Drake, Joshua C, Peelor, 3rd, Frederick F, Biela, Laurie M, Geor, Raymond, Hinchcliff, Kenneth, Davis, Michael, Hamilton, Karyn L

“…The Alaskan Husky has been specifically bred for endurance performance and is capable of extreme endurance performance. We examined sled dogs in the trained…”
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