Search Results - "Peel, Michael R."

Synthesis and biological evaluation of antifungal derivatives of enfumafungin as orally bioavailable inhibitors of β-1,3-glucan synthase by Heasley, Brian H., Pacofsky, Gregory J., Mamai, Ahmed, Liu, Hao, Nelson, Kingsley, Coti, Ghjuvanni, Peel, Michael R., Balkovec, James M., Greenlee, Mark L., Liberator, Paul, Meng, Dongfang, Parker, Dann L., Wilkening, Robert R., Apgar, James M., Racine, F., Hsu, Ming Jo, Giacobbe, Robert A., Kahn, Jennifer Nielsen

“…Orally bioavailable inhibitors of β-(1,3)-d-glucan synthase have been pursued as new, broad-spectrum fungicidal therapies suitable for treatment in…”
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Pyrazolo[1,5-a]pyridines as p38 Kinase Inhibitors by Stevens, Kirk L, Jung, David K, Alberti, Michael J, Badiang, Jennifer G, Peckham, Gregory E, Veal, Jim M, Cheung, Mui, Harris, Philip A, Chamberlain, Stanley D, Peel, Michael R

“…A convergent synthesis of substituted pyrazolo[1,5-a]pyridines has been achieved either via a regioselective [3 + 2] cycloaddition of N-aminopyridines with…”
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The identification of pyrazolo[1,5- a]pyridines as potent p38 kinase inhibitors by Cheung, Mui, Harris, Philip A., Badiang, Jennifer G., Peckham, Gregory E., Chamberlain, Stanley D., Alberti, Michael J., Jung, David K., Harris, Stephanie S., Bramson, Neal H., Epperly, Andrea H., Stimpson, Stephen A., Peel, Michael R.

“…A series of pyrazolo[1,5- a]pyridine derivatives was designed and synthesized as novel potent p38 kinase inhibitors. Our approaches towards improving in vitro…”
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A topical aqueous calcineurin inhibitor for the treatment of naturally occurring keratoconjunctivitis sicca in dogs by Gilger, Brian C., Wilkie, David A., Salmon, Jacklyn H., Peel, Michael R.

“…Purpose  The purpose of this study was to evaluate the efficacy of an aqueous calcineurin inhibitor, SCY‐641, in the treatment of naturally occurring canine…”
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Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors by Stevens, Kirk L., Reno, Michael J., Alberti, Jennifer B., Price, Daniel J., Kane-Carson, Laurie S., Knick, Victoria B., Shewchuk, Lisa M., Hassell, Anne M., Veal, James M., Davis, Stephen T., Griffin, Robert J., Peel, Michael R.

“…A novel series of pyrazolo[1,5-b]pyridazines have been synthesized and identified as cyclin dependant kinase inhibitors potentially useful for the treatment of…”
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The discovery of potent cRaf1 kinase inhibitors by LACKEY, K, CORY, M, RUTKOWSKE, R. D, VEAL, J. M, WOOD, E. R, DAVIS, R, FRYE, S. V, HARRIS, P. A, HUNTER, R. N, JUNG, D. K, MCDONALD, O. B, MCNUTT, R. W, PEEL, M. R

“…A series of benzylidene-1H-indol-2-one (oxindole) derivatives was synthesized and evaluated as cRaf-1 kinase inhibitors. The key features of the molecules were…”
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A short, enantioselective synthesis of the carbocyclic nucleoside carbovir by Peel, Michael R, Sternbach, Daniel D, Johnson, M. Ross

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Pyrazolo[1,5- a]pyridines: synthetic approaches to a novel class of antiherpetics by Johns, Brian A, Gudmundsson, Kristjan S, Turner, Elizabeth M, Allen, Scott H, Jung, David K, Sexton, Connie J, Boyd, F.Leslie, Peel, Michael R

“…Synthesis of a novel class of 7-amino-3-pyrimidinyl-pyrazolo[1,5- a]pyridine antiherpetic compounds is described. The synthetic methodology is designed to…”
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Peptide Ligands of pp60c-src SH2 Domains:  A Thermodynamic and Structural Study by Charifson, Paul S, Shewchuk, Lisa M, Rocque, Warren, Hummel, Conrad W, Jordan, Steven R, Mohr, Christopher, Pacofsky, Gregory J, Peel, Michael R, Rodriguez, Marc, Sternbach, Daniel D, Consler, Thomas G

“…Thermodynamic measurements, structural determinations, and molecular computations were applied to a series of peptide ligands of the pp60c-src SH2 domain in an…”
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Synthesis of 5-Substituted 7-Azaoxindoles via Palladium-catalyzed Reactions by Cheung, Mui, N. Hunter III, Robert, R. Peel, Michael, E. Lackey, Karen

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Asylum Seekers And Refugees In Britain: The Health Of Survivors Of Torture And Organised Violence by Burnett, Angela, Peel, Michael

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The sexual abuse of men in detention in Sri Lanka by Peel, M, Mahtani, A, Hinshelwood, G, Forrest, D

“…Other difficulties for male rape victims are caused by common myths about male rape, for example, the belief that men cannot get an erection and ejaculate…”
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Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study by Charifson, P S, Shewchuk, L M, Rocque, W, Hummel, C W, Jordan, S R, Mohr, C, Pacofsky, G J, Peel, M R, Rodriguez, M, Sternbach, D D, Consler, T G

“…Thermodynamic measurements, structural determinations, and molecular computations were applied to a series of peptide ligands of the pp60(c-src) SH2 domain in…”
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Asylum Seekers And Refugees In Britain: Health Needs Of Asylum Seekers And Refugees by Burnett, Angela, Peel, Michael

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Effects on asylum seekers of ill treatment in Zaire by Peel, M R

“…To describe the health effects of the political system in Zaïre on asylum seekers seen at the Medical Foundation for the Care of Victims of Torture a…”
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The formation of a covalent complex between a dipeptide ligand and the src SH2 domain by Alligood, Krystal J., Charifson, Paul S., Crosby, Renae, Consler, Thomas G., Feldman, Paul L., Gampe, Robert T., Gilmer, Tona M., Jordan, Steven R., Milstead, Mark W., Mohr, Christopher, Peel, Michael R., Rocque, Warren, Rodriguez, Marc, Rusnak, David W., Shewchuk, Lisa M., Sternbach, Daniel D.

“…The X-ray crystal structure of the src SH2 domain revealed the presence of a thiol residue (Cys 188) located proximal to the phosphotyrosine portion of a…”
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Novel A-ring modified camptothecins as topoisomerase I inhibitors by Peel, Michael R., Milstead, Mark W., Sternbach, Daniel D., Besterman, Jeffrey M., Leitner, Peter, Morton, Bradley, Wall, Monroe E., Wani, Mansukh C.

“…A camptothecin derivative has been prepared wherein the A-ring is fused to an oxazole ring. The compound was prepared via a Friedlander condensation involving…”
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Peptide Ligands of pp60 c-src SH2 Domains:  A Thermodynamic and Structural Study by Charifson, Paul S., Shewchuk, Lisa M., Rocque, Warren, Hummel, Conrad W., Jordan, Steven R., Mohr, Christopher, Pacofsky, Gregory J., Peel, Michael R., Rodriguez, Marc, Sternbach, Daniel D., Consler, Thomas G.

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A prodrug approach to the design of cRaf1 kinase inhibitors with improved cellular activity by Wood, E, Crosby, R M, Dickerson, S, Frye, S V, Griffin, R, Hunter, R, Jung, D K, McDonald, O B, McNutt, R, Mahony, W B, Peel, M R, Ray, J, Lackey, K

“…Earlier we reported potent cRaf1 kinase inhibitors with a key acidic phenol pharmacophore that had, at best, adequate cellular efficacy. To improve the…”
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