Search Results - "Peebles, R.S"

Prostaglandin I2 Receptor (IP) Signaling Inhibits Antigen Uptake but Induce the Ability of Migration on Immature Dendritic Cells by Toki, S, Goleniewska, K, FitzGerald, G.A, Peebles, R.S

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TGF-β, IL-1β, And IL-23 Are Required For IL-13Rα1 Expression On Human Th17 Cells And IL-13 Attenuates IL-17A Production At Restimulation by Huckabee, M.M, Newcomb, D.C, Boswell, M.G, Goleniewska, K, Reiss, S, Peebles, R.S

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Il-13 Receptor Alpha 1 Is Expressed On T Cells In Vivo And Il-13 Regulates RSV-Induced Il-17A Production In STAT1-/- Mice by Boswell, M.G, Newcomb, D.C, Huckabee, M.M, Goleniewska, K, Reiss, S.S, Peebles, R.S

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Silymarin Reduces OVA-induced Allergic Airway Inflammation by Newcomb, D.C, Boswell, M.G, Huckabee, M.M, Markowitz, J.S, Hartert, T.V, Peebles, R.S

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IL-17A-mediated STAT6 Independent Mucus Production in Mice by Boswell, M.G, Newcomb, D.C, Goleniewska, K, Reiss, S, Adler, K.B, Peebles, R.S

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Attenuated Allergic Airway Inflammation in gp91phox KO Mice is Due to Altered Dendritic Cell Function by Sevin, C.M, Newcomb, D.C, Huckabee, M.M, Goleniewska, K, Blackwell, T.S, Peebles, R.S

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IL-13 Decreases IL-17a Production In Mouse Th17 Cells Through An IL-10 Dependent Mechanism by Newcomb, D.C, Huckabee, M.M, Boswell, M.G, Goleniewska, K, Reiss, S.S, Peebles, R.S

“…When Th17 cells were polarized in the presence of IL-13, anti-IL-10 prevented the IL-13-mediated decrease in Th17 cytokine production. p<0.05, n=5-8 for all…”
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Human CD4+ Th17 Cells Express A Functional IL-13 Receptor And IL-13 Signaling Negatively Regulates IL-17A Production by Newcomb, D.C, Zhou, W, Goleniewska, K, Peebles, R.S

“…Naïve CD4+ cells were isolated from blood, activated with anti-CD3 and anti-CD28, and polarized into Th17 cells using IL-2, TGF-β, IL-1β, IL-6, IL-23,…”
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Lack of p47phox , the Active Subunit of the NADPH Oxidase Complex, Augments Ovalbumin-induced Allergic Airway Inflammation in Mice by Sevin, C.M, Newcomb, D.C, Goleniewska, K, Blackwell, T.S, Peebles, R.S

“…[...]we hypothesized that p47phox knockout (KO) mice would have decreased ovalbumin (OVA)-induced allergic inflammation compared to wild type (WT) mice…”
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Signaling through the PGI2 Receptor Promotes IL-17 Production by CD4 T Cells by Huckabee, M.M, Zhou, W, Newcomb, D.C, Goleniewska, K, FitzGerald, G.A, Peebles, R.S

“…The effect of iloprost and cicaprost on IL-17 production by IP KO/OT II T cells was significantly attenuated compared to the effect on control OT II T cells…”
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IL-13 Does Not Attenuate Phosphorylation Of STAT3 In Mouse CD4+ Th17 Polarized Cells by Boswell, M.G, Chi, M.H, Newcomb, D.C, Peebles, R.S

“…IL-13 signaling did not attenuate STAT3 phosphorylation in CD4+ Th17 cells, suggesting that the IL-13 signaling pathway must regulate Th17 cell differentiation…”
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STAT1 Negatively Regulates Basophil IL-4 Expression Induced by Respiratory Syncytial Vrus Infection by Moore, M.L, Parekh, V.V, Van Kaer, L, Collins, R.D, Goleniewska, K, Chi, M.H, Mitchell, D, Durbin, J.E, Peebles, R.S

“…RSV infection resulted in more IL-4-expressing basophils in the lungs of STAT1-/- mice than in wild-type BALB/c mice.We ruled out NK cells, NKT cells, mast…”
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A Functional IL-13 Receptor is Expressed on Polarized Murine CD4 + Th17 Cells and IL-13 Signaling Negatively Regulates Th17 Cytokine Production by Newcomb, D.C, Zhou, W, Moore, M.L, Goleniewska, K, Hershey, G.K.K, Kolls, J.K, Peebles, R.S

“…IL-13 also negatively regulates IL-17A and IL-21 production. [...]using therapeutics to inhibit IL-13 production could have adverse consequences by…”
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PGE2 in Synergy with IL-23 Drives Robust IL-17 Production and Th17 Differentiation by Inhibiting the STAT6 Signaling Pathway by Zhou, W, Huckabee, M.M, Newcomb, D.C, Goleniewska, K, Ji, S, Breyer, R.M, Peebles, R.S

“…Frequent use of cyclooxygenase-inhibiting and PGE2-suppressing drugs may disturb the balance of Th lineages in the immune system and affect the host defense…”
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Respiratory Syncytial Virus Infections Augment Allergen-Specific T Cell Secretion of Lung IL-17A by Newcomb, D.C, Moore, M.L, Goleniewska, K, Zhou, W, Peebles, R.S

“…Conclusions RSV infection augments the allergen-specific T cell production of lung IL-17A and therefore fundamentally changes the immune response against an…”
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Prostaglandin I2 Receptor (IP) Signaling Inhibits TLR4 Cell Surface Expression and Reduces LPS-induced Lung Inflammation by Toki, S, Zhou, W, Goleniewska, K, FitzGerald, G.A, Peebles, R.S

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Prostaglandin I2 Signaling Exacerbates Experimental Autoimmune Encephalomyelitis by Dowell, D.R, Zhou, W, Huckabee, M.M, Newcomb, D.C, Goleniewska, K, Fitzgerald, G.A, Peebles, R.S

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The Deficiency of PGI2 Signaling Induces STAT6-independent Allergic Airway Inflammation by Zhou, W, Dowell, D.R, Huckabee, M.M, Newcomb, D.C, Goleniewska, K, FitzGerald, G, Peebles, R.S

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A Clinical Isolate Strain of Respiratory Syncytial Virus (RSV) Causes Airway Obstruction and Histopathology in Mice Similar to Severe RSV Disease in Infants by Moore, M.L, Chi, M.H, Williams, J.V, Wright, P.F, Crowe, J.E, Edwards, K.M, Polosukhin, V.V, Goleniewska, K, Peebles, R.S

“…A/Nashville/2001/2-20 infection caused high lung IL-13 and mucus levels, epithelial cell damage, and smooth muscle damage and hyperplasia in BALB/c mice…”
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Natural Killer (NK) Cells, Not T Cells, Produce the Cytokine IL-4 in Response to Primary Respiratory Syncytial Virus Infection by Moore, M.L, Parekh, V.V, Van Kaer, L, Collins, R.D, Goleniewska, K, O'Neal, J.F, Chi, M.H, Durbin, J.E, Peebles, R.S

“…[...]experiments in STAT1-deficient mice revealed a 2.5-fold increase in the number of NK cells expressing IL-4 in response to RSV infection, compared to…”
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