Search Results - "Peduto, Lucie"
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The perivascular origin of pathological fibroblasts
Published in The Journal of clinical investigation (02-01-2018)“…The ability to repair tissues is essential for the survival of organisms. In chronic settings, the failure of the repair process to terminate results in…”
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CD34⁺ mesenchymal cells are a major component of the intestinal stem cells niche at homeostasis and after injury
Published in Proceedings of the National Academy of Sciences - PNAS (24-01-2017)“…The intestinal epithelium is continuously renewed by intestinal epithelial stem cells (IESCs) positioned at the base of each crypt. Mesenchymal-derived factors…”
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ADAM9 as a potential target molecule in cancer
Published in Current pharmaceutical design (2009)“…ADAM (a disintegrin and metalloproteinase) proteins have a predominant role in the protein ectodomain shedding of membrane-bound molecules. ADAMs have emerged…”
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Lineage tracing and genetic ablation of ADAM12+ perivascular cells identify a major source of profibrotic cells during acute tissue injury
Published in Nature Medicine (01-08-2012)“…Organ fibrosis often leads to end-stage organ failure, but the origin of key profibrotic cell types is still unclear. Lucie Peduto and her colleagues have used…”
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Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation
Published in Immunity (Cambridge, Mass.) (16-01-2018)“…Group 3 innate lymphoid cells (ILC3s) sense environmental signals and are critical for tissue integrity in the intestine. Yet, which signals are sensed and…”
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Chikungunya virus-induced autophagy delays caspase-dependent cell death
Published in The Journal of experimental medicine (07-05-2012)“…Autophagy is an important survival pathway and can participate in the host response to infection. Studying Chikungunya virus (CHIKV), the causative agent of a…”
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Global proteomic identifies multiple cancer-related signaling pathways altered by a gut pathobiont associated with colorectal cancer
Published in Scientific reports (11-09-2023)“…In this work, we investigated the oncogenic role of Streptococcus gallolyticus subsp. gallolyticus ( SGG ), a gut bacterium associated with colorectal cancer…”
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Type I IFN controls chikungunya virus via its action on nonhematopoietic cells
Published in The Journal of experimental medicine (15-02-2010)“…Chikungunya virus (CHIKV) is the causative agent of an outbreak that began in La Réunion in 2005 and remains a major public health concern in India, Southeast…”
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An optimized protocol for isolating lymphoid stromal cells from the intestinal lamina propria
Published in Journal of immunological methods (01-06-2015)“…Mesenchymal stromal cells in lymphoid organs, also called lymphoid stromal cells (LSCs), play a pivotal role in immunity by forming specialized…”
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Genetic screens reveal mechanisms for the transcriptional regulation of tissue-specific genes in normal cells and tumors
Published in Nucleic acids research (23-04-2019)“…Abstract The proper tissue-specific regulation of gene expression is essential for development and homeostasis in metazoans. However, the illegitimate…”
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Inflammation Recapitulates the Ontogeny of Lymphoid Stromal Cells
Published in The Journal of immunology (1950) (01-05-2009)“…Stromal cells in lymphoid tissues regulate lymphocyte recruitment and survival through the expression of specific chemokines and cytokines. During…”
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Characterization of the Thymic IL-7 Niche in Vivo
Published in Proceedings of the National Academy of Sciences - PNAS (03-02-2009)“…The thymus represents the "cradle" for T cell development, with thymic stroma providing multiple soluble and membrane cues to developing thymocytes. Although…”
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Chikungunya-induced cell death is limited by ER and oxidative stress-induced autophagy
Published in Autophagy (01-08-2012)“…It has been recognized that macroautophagy constitutes an important survival mechanism that allows both the maintenance of cellular homeostasis and the…”
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T cells regulate lymph node-resident ILC populations in a tissue and subset-specific way
Published in iScience (19-03-2021)“…Innate lymphoid cells (ILCs) have been shown to be significantly affected in the small intestine lamina propria and secondary lymphoid organs (SLOs) of…”
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Critical function for ADAM9 in mouse prostate cancer
Published in Cancer research (Chicago, Ill.) (15-10-2005)“…ADAM9 is a membrane-anchored metalloprotease that is markedly up-regulated in several human carcinomas. Here, we show that ADAM9 is similarly up-regulated in…”
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Mesenchymal perivascular cells in immunity and disease
Published in Current opinion in immunology (01-06-2020)“…•Perivascular mesenchymal cells include pericytes, adventitial fibroblasts and mesenchymal stromal cells.•Perivascular mesenchymal cells have roles in the…”
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The Endothelin System in Human Glioblastoma
Published in Laboratory investigation (01-11-2000)“…Endothelin-1 (ET-1) is a powerful mitogenic and/or anti-apoptotic peptide produced by many cancer cells. To evaluate the potential role of the endothelin…”
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Stromal regulation of the intestinal barrier
Published in Mucosal immunology (01-04-2023)“…The intestinal barrier is a complex structure that allows the absorption of nutrients while ensuring protection against intestinal pathogens and balanced…”
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The perivascular origin of pathological fibroblasts
Published in The Journal of clinical investigation (01-01-2018)“…Unite Stroma, Inflammation and Tissue Repair, Institut Pasteur, Paris, France, and INSERM U1224, Paris, France. The ability to repair tissues is essential for…”
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