Search Results - "Pedro de Freitas, Luis Alexandre"

Safety of a formulation containing chitosan microparticles with chamomile: blind controlled clinical trial by Garbuio, Danielle Cristina, Zamarioli, Cristina Mara, Melo, Maísa Oliveira de, Campos, Patrícia Maria Berardo Gonçalves Maia, Carvalho, Emília Campos de, Freitas, Luis Alexandre Pedro de

“…to evaluate the safety of a topical formulation containing chamomile microparticles coated with chitosan in the skin of healthy participants. phase I blind,…”
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Comparative study of curcumin and curcumin formulated in a solid dispersion: Evaluation of their antigenotoxic effects by Mendonça, Leonardo Meneghin, Machado, Carla da Silva, Teixeira, Cristiane Cardoso Correia, Freitas, Luis Alexandre Pedro de, Bianchi, Maria Lourdes Pires, Antunes, Lusânia Maria Greggi

“…Curcumin (CMN) is the principal active component derived from the rhizome of Curcuma longa (Curcuma longa L.). It is a liposoluble polyphenolic compound that…”
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Topical Formulation Containing Beeswax-Based Nanoparticles Improved In Vivo Skin Barrier Function by Souza, Carla, de Freitas, Luis Alexandre Pedro, Maia Campos, Patrícia Maria Berardo Gonçalves

“…Lipid nanoparticles have shown many advantages for treatment/prevention of skin disorders with damaged skin barrier function. Beeswax is a favorable candidate…”
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Dynamic maceration of Matricaria chamomilla inflorescences: optimal conditions for flavonoids and antioxidant activity by Pereira, Simone Vieira, Reis, Rayssa A.S.P., Garbuio, Danielle Cristina, Freitas, Luis Alexandre Pedro de

“…The aim of this paper was to study and optimize the dynamic maceration process to obtain Matricaria chamomilla L., Asteraceae, inflorescences extracts with…”
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A multivariate approach applied to quality on particle engineering of spray-dried mannitol by Guimarães, Thiago Frances, Lanchote, Aurea D., da Costa, Jéssica Silva, Viçosa, Alessandra Lifsitch, de Freitas, Luís Alexandre Pedro

“…[Display omitted] •First study using response surface methodology to spray drying of mannitol.•Outlet temperature affected particle shape.•Mannitol solubility…”
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Curcumin suppresses inflammatory cytokines and heat shock protein 70 release and improves metabolic parameters during experimental sepsis by Silva, Letycia Silvano da, Catalão, Carlos Henrique Rocha, Felippotti, Tatiana Tocchini, Oliveira- Pelegrin, Gabriela Ravanelli de, Petenusci, Sérgio, de Freitas, Luis Alexandre Pedro, Rocha, Maria José Alves

“…Context: Curcumin has been reported to have anti-inflammatory, antioxidant and hypoglycaemic properties, besides reducing mortality in sepsis. Objective: This…”
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Chitosan microparticles for sustaining the topical delivery of minoxidil sulphate by Gelfuso, Guilherme Martins, Gratieri, Taís, Simão, Patrícia Sper, de Freitas, Luís Alexandre Pedro, Lopez, Renata Fonseca Vianna

“…Given the hypothesis that microparticles can penetrate the skin barrier along the transfollicular route, this work aimed to obtain and characterise chitosan…”
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Ultrasound influence on the solubility of solid dispersions prepared for a poorly soluble drug by Pereira, Simone Vieira, Colombo, Fábio Belotti, de Freitas, Luis Alexandre Pedro

“…•First work to evaluate the ultrasound effect on pharmaceutical solid dispersions.•Use of multivariate analysis to evaluate ultrasound parameters.•Complete…”
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Available technologies on improving the stability of polyphenols in food processing by Cao, Hui, Saroglu, Oznur, Karadag, Ayse, Diaconeasa, Zoriţa, Zoccatelli, Gianni, Conte‐Junior, Carlos Adam, Gonzalez‐Aguilar, Gustavo A., Ou, Juanying, Bai, Weibin, Zamarioli, Cristina Mara, Freitas, Luis Alexandre Pedro, Shpigelman, Avi, Campelo, Pedro H., Capanoglu, Esra, Hii, Ching Lik, Jafari, Seid Mahdi, Qi, Yaping, Liao, Pan, Wang, Mingfu, Zou, Liang, Bourke, Paula, Simal‐Gandara, Jesus, Xiao, Jianbo

“…Polyphenols are the most important phytochemicals in our diets and have received great attention due to their broad benefits for human health by suppressing…”
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Spray-dried bacterial cellulose nanofibers: A new generation of pharmaceutical excipient intended for intestinal drug delivery by Meneguin, Andréia Bagliotti, da Silva Barud, Hernane, Sábio, Rafael Miguel, de Sousa, Paula Zanin, Manieri, Karyn Fernanda, de Freitas, Luís Alexandre Pedro, Pacheco, Guilherme, Alonso, Jovan Duran, Chorilli, Marlus

“…[Display omitted] •Ultra-refining was effective to defibrillate bacterial cellulose membranes.•The nanofibers collapse after spray drying makes their…”
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Analysis of interactions between polymeric gel and esophageal mucosae by a multivariate experimental approach by Oteiro, Aimee Accarini, Delboni, Lariani Aparecida, Pedro de Freitas, Luis Alexandre, Lara, Marilisa Guimarães

“…Gels with mucoadhesive properties have been proposed to deliver drugs by several routes of administration. The aim of this work was to study the in vitro…”
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Solid state stability of polyphenols from a plant extract after fluid bed atmospheric spray-freeze-drying by Teixeira, Cristiane Cardoso Correia, Cabral, Tatiana Pereira de Freitas, Tacon, Luciana Alves, Villardi, Isabel Lemos, Lanchote, Aurea Donizete, Freitas, Luis Alexandre Pedro de

“…Dry powder extracts are the most suitable pharmaceutical forms of phytomedicines due to their greater physical and chemical stability in the solid state, in…”
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Curcumin reduces cisplatin-induced neurotoxicity in NGF-differentiated PC12 cells by Mendonça, Leonardo Meneghin, da Silva Machado, Carla, Correia Teixeira, Cristiane Cardoso, Pedro de Freitas, Luis Alexandre, Pires Bianchi, Maria de Lourdes, Greggi Antunes, Lusânia Maria

“…► Curcumin reduced cisplatin-induced neurite toxicity in a PC12 cell model by up to 50%. ► Curcumin's neuroprotective effects did not involve suppression of…”
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Artemia salina Leach in photoprotection: A new model to evaluate the potential of nanoparticles for topical application by Gonçalo das Neves e Silva, Eullállia, Ferreira Barbosa, Gustavo Luis, Alves Confessor, Maine Virgínia, Bacalhau de Sousa, Wladymyr Jefferson, Lia Fook, Marcus Vinicius, Siqueira-Júnior, José P., Pedro de Freitas, Luis Alexandre, Martins, Rodrigo Molina

“…Using animals in research has generated heated debates around the world and in the scientific community. This fact, as well as the need to prove the safety and…”
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Enantioselective analysis of oxybutynin and N-desethyloxybutynin with application to an in vitro biotransformation study by da Fonseca, Patrícia, de Freitas, Luis Alexandre Pedro, Pinto, Luis Felipe Ribeiro, Pestana, Cezar Rangel, Bonato, Pierina Sueli

“…An enantioselective method using liquid-phase microextraction (LPME) followed by HPLC analysis was developed for the determination of oxybutynin (OXY) and its…”
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Fluidized Bed Hot-Melt Granulation as a Tool to Improve Curcuminoid Solubility by Teixeira, Cristiane C. C., de Paiva Junior, Elias, de Freitas, Luis Alexandre Pedro

“…Curcumin is the main bioactive component of Curcuma longa L. and has recently aroused growing interest from the scientific community. Unfortunately, the…”
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Development of enteric coated tablets from spray dried extract of feverfew (Tanacetum parthenium L: ) by Chaves, Juliana Siqueira, Da Costa, Fernando Batista, Freitas, Luís Alexandre Pedro de

“…Tanacetum parthenium (feverfew) is an herb that is commercialized worldwide as a therapeutic treatment for migraine. Its pharmacological effect is mainly due…”
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Multivariate Analysis of the Stability of Spray-Dried Eupenicillium javanicum Peptidases by Hamin Neto, Youssef Ali Abou, de Freitas, Luis Alexandre Pedro, Cabral, Hamilton

“…Peptidases occupy a central position in the enzyme market because of their importance in many areas, such as for physiological processes, foods, and…”
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Spray Cooling Process Factors and Quality Interactions During the Preparation of Microparticles Containing an Active Pharmaceutical Ingredient by Pereira, Simone Vieira, Colombo, Fábio Belotti, Martins, Rodrigo Molina, Pedro de Freitas, Luis Alexandre

“…The current work studies the spray-cooling process factors and quality interactions during the production of microparticulated solid dispersions containing…”
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Box-Behnken design for the optimization of an enantioselective method for the simultaneous analysis of propranolol and 4-hydroxypropranolol by CE by Borges, Keyller Bastos, Pupo, Mônica Tallarico, de Freitas, Luis Alexandre Pedro, Bonato, Pierina Sueli

“…An experimental design optimization (Box-Behnken design, BBD) was used to develop a CE method for the simultaneous resolution of propranolol (Prop) and…”
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